A5028445459- Antibiotic Resistance in Bacteria
- Bacterial biofilms and quorum sensing
- Antibiotics Pharmacokinetics and Efficacy
- Respiratory viral infections research
- Pharmaceutical and Antibiotic Environmental Impacts
- Mycobacterium research and diagnosis
- Pneumonia and Respiratory Infections
- Antifungal resistance and susceptibility
- Enterobacteriaceae and Cronobacter Research
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Gut microbiota and health
- Infections and bacterial resistance
- Tracheal and airway disorders
- Fungal Infections and Studies
- Vibrio bacteria research studies
- Genomics and Phylogenetic Studies
- Antibiotic Use and Resistance
- Plant Pathogenic Bacteria Studies
- Bacterial Identification and Susceptibility Testing
- Infectious Diseases and Mycology
- Cancer-related molecular mechanisms research
- Urinary Tract Infections Management
- MicroRNA in disease regulation
- High Temperature Alloys and Creep
- Bacteriophages and microbial interactions
China-Japan Friendship Hospital
2019-2025
Southwest University
2025
Chinese Academy of Medical Sciences & Peking Union Medical College
2020-2025
National Clinical Research
2024-2025
Academy of Medical Sciences
2024-2025
National Clinical Research Center for Digestive Diseases
2022-2024
Northeastern University
2024
Center for Life Sciences
2020-2021
Tsinghua University
2020-2021
Peking University
2020-2021
This paper describes the microfluidic streak plate (MSP), a facile method for high-throughput microbial cell separation and cultivation in nanoliter sessile droplets. The MSP builds upon conventional technique by using devices to generate droplets that can be streaked manually or robotically onto petri dishes prefilled with carrier oil of single cells. In addition, chemical gradients could encoded droplet array comprehensive dose-response analysis. was validated single-cell isolation...
ST11 Klebsiella pneumoniae is among the most important clinical pathogens in China, and KL47 KL64 are dominant K types of these strains. Understanding genomic characteristics strains would be critical to their anti-infection treatment.There were 364 genome sequences K. isolated collected from 13 countries 2003 2018. These included 338 downloaded National Center for Biotechnology Information (NCBI) database 26 newly sequenced. Phylogenetic analyses pan-genome unique genes, resistance...
Polymyxin has been the last resort to treat multidrug-resistant Klebsiella pneumonia. However, recent studies have revealed that polymyxin-resistant carbapenem-resistant pneumonia (PR-CRKP) emerged due mutations in chromosomal genes or plasmid-harboring
This paper compares the application of Weibull distribution and Crow-AMSAA (C-A) model to analysis cable joint failures. The procedures on how use two models analyze failure data predict future number failures have been described before are applied a set early data. data, which include 16 1126 suspensions, were collected from regional power-supply company in China. proves that provides more reliable results early-failure since it considers time each event. Whilst method is straightforward...
Currently, society is in a period of rapid aging. With the development economy, China also at critical stage where aging degree accelerating and population structure changing. The health issues elderly have received widespread attention from society. in-depth implementation "Healthy China" strategy, addressing challenges brought about by has become an important topic. Through methods literature review mathematical statistics, this paper analyzes current status under background China",...
<title>Abstract</title> Fitness Qigong and Tai Chi, as forms of exercise therapy, are suitable for Parkinson's disease (PD) patients who mainly middle-aged elderly, their effectiveness has been proven by an increasing number studies. However, there is a serious issue in some previous studies, which the misconception considering Chi specific form exercise. In fact, not single exercise, but rather general term category exercises. Since fitness effects different types exactly same, it necessary...
Pseudomonas aeruginosa bacteremia presents a severe challenge to hospitalized patients. However, date, the risk factors for mortality among inpatients with P. in China remain unclear.This retrospective multicenter study was performed analyze 215 patients culture-confirmed five healthcare centers during years 2012-2019.Of bacteremia, 61 (28.4%) died period. Logistic multivariable analysis revealed that cardiovascular disease (OR=3.978, P=0.001), blood transfusion (OR=5.855, P<0.001) and...
Abstract Background Respiratory syncytial virus (RSV) is an important cause of medically attended acute respiratory illnesses in older adults but awareness the relevance RSV people remains lower than that influenza, which exhibits similar clinical characteristics to those RSV. Objectives This study was performed assess significance samples from hospitalized adults. Methods Characteristics and outcomes (≥18 years) for infection (n = 51) were compared with a cohort influenza A 279)...
ABSTRACT The carbapenem-resistant Klebsiella pneumoniae (CRKP) strain GX34 was recovered from the respiratory tract of an elderly male with severe pneumonia, and only susceptible to amikacin, tigecycline, colistin. Complete genome suggested that it belonged K51-ST16 harbored plasmid-encoded NDM-4 OXA-181, located on IncFIB plasmid GX34p1_NDM-4 ColKP3/IncX3 GX34p4_OXA-181, respectively. A series transconjugants generated in conjugation assays, including Escherichia coli J53-N1 (harboring a...
The Xpert Xpress Flu/RSV assay is released by FDA for rapid detection of influenza A (FluA), B (FluB), and respiratory syncytial virus (RSV). This study aimed to evaluate its clinical performance in comparison that the RT-PCR cleared China (CFDA-PCR).Nasopharyngeal specimens were collected from patients tested two assays side side. Discordant results with a laboratory-developed real-time PCR resolution. Viral load sample was quantified droplet digital PCR.A total 658 involved gave...
Tuberculosis remains a major global public concern as leading cause of health care-associated infections. The detection Mycobacterium tuberculosis (MTB) is challenging due to the paucibacillary nature pathogen. For suspected pulmonary and extrapulmonary patients, if sputum, bronchoalveolar lavage fluid (BALF), related samples are negative for MTB, or tumors, biopsy tissues may provide better diagnostic yield. This study was aimed at comparing performances three methods in identifying MTB...
Cefiderocol is a siderophore cephalosporin that binds ferric iron and utilizes transporters to cross the cell membrane. Hypervirulent Klebsiella pneumoniae (hvKp) known produce more siderophores; in this case, uptake of cefiderocol may be decreased. Therefore, objective study was evaluate vitro activity against hvKp isolates. A total 320 carbapenem-resistant K. (CRKp) isolates were collected China between 2014 2022, including 171 (CR-hvKp) 149 classical (CR-cKp). Quantitative detection...
We describe in vivo evolution of carbapenem and ceftazidime-avibactam resistance by analyzing four longitudinal Klebsiella pneumoniae clinical isolates from a patient with pneumonia following antimicrobial treatment. The had fever, cough associated expectoration, new infiltration was found on the chest CT. Antimicrobial susceptibility determined, whole genome sequencing (WGS) performed to investigate its dynamic change phenotype. Population analysis profile population . infection started...
Introduction The increase in clinical Enterobacteriaceae with dual carbapenemase has become a serious healthcare concern. It is essential to characterize the transferability and potential dissemination of bla KPC−2 - NDM−1 -coharboring carbapenem-resistant Citrobacter freundii (CRCF). Methods Four CRCF strains were collected from our surveillance prevalence . isolates assessed using species identification, antimicrobial susceptibility testing, conjugation assays, whole-genome sequencing,...
The emergence of pathogens co-harbouring multiple mobile resistance and virulence elements is great concern in clinical settings. Herein, we report an O101: H10-ST167 Escherichia coli Hu106 strain isolated from the urinary tract a female China. Antibiotic susceptibility testing was used to present antimicrobial spectrum. Whole-genome sequencing (WGS) bioinformatic analysis were clarify virulent mechanisms. Furthermore, this tested by Greater wax moth larvae siderophore production experiment....
Objectives This study aimed at revealing the underlying mechanisms of loss and gain ceftazidime-avibactam susceptibility in a non-carbapenemase-producing hypervirulent Klebsiella pneumoniae (hvKp).