A5100747909- Clostridium difficile and Clostridium perfringens research
- Offshore Engineering and Technologies
- Engineering Structural Analysis Methods
- Soil Carbon and Nitrogen Dynamics
- Structural Integrity and Reliability Analysis
- Pharmacological Effects of Natural Compounds
- Advanced Sensor and Control Systems
- Drilling and Well Engineering
- Wave and Wind Energy Systems
- Viral gastroenteritis research and epidemiology
- Advanced Algorithms and Applications
- Maritime Transport Emissions and Efficiency
- Mechanical stress and fatigue analysis
- Experimental Learning in Engineering
- Toxin Mechanisms and Immunotoxins
- Forest ecology and management
- Forest Ecology and Biodiversity Studies
- Hydraulic Fracturing and Reservoir Analysis
- Geotechnical Engineering and Underground Structures
- Vibration and Dynamic Analysis
- Pediatric Hepatobiliary Diseases and Treatments
- Optical Systems and Laser Technology
- Internet of Things and Social Network Interactions
- Embedded Systems and FPGA Design
- Gene Regulatory Network Analysis
Shanghai Maritime University
2016-2025
Chinese Academy of Forestry
2012-2024
Guangdong University of Technology
2022-2024
Experimental Center of Tropical Forestry
2012-2024
Wuhan University
2024
Hudson Institute
2023
PetroChina Southwest Oil and Gas Field Company (China)
2022-2023
Guangdong Pharmaceutical University
2023
Sichuan Institute of Building Research
2023
China State Construction Engineering (China)
2023
The continuous development of floating wind turbine technology is pushing platforms further offshore into deeper seas. Consequently, the water depth required for mooring increasing, demanding higher standards system. This study explores mechanical properties, including wear resistance and quasi-static stiffness, nylon, polyester, high-strength polyethylene ropes through experimental design, aiming to address challenges faced by turbines (FOWT) in line safety. In conducting yarn-on-yarn...
Abstract C. difficile is a major cause of antibiotic-associated gastrointestinal infections. Two exotoxins (TcdA and TcdB) are virulence factors associated with these infections, chondroitin sulfate proteoglycan 4 (CSPG4) potential receptor for TcdB, but its pathophysiological relevance the molecular details that govern recognition remain unknown. Here, we determine cryo-EM structure TcdB–CSPG4 complex, revealing unique binding site spatially composed multiple discontinuous regions across...
Clostridioides difficile is the major worldwide cause of antibiotic-associated gastrointestinal infection. A pathogenicity locus (PaLoc) encoding one or two homologous toxins, toxin (TcdA) and B (TcdB), essential for C . pathogenicity. However, sequence variation poses challenges development diagnostic assays, therapeutics, vaccines. Here, we present a comprehensive phylogenomic analysis 8,839 strains their toxins including 6,492 genomes that assembled from NCBI short read archive. total...
The limestone reservoir of the Da’anzhai section is main production layer Jurassic tight oil in central Sichuan, with and strongly heterogeneous rocks. In early stages, small-scale plug removal acidification techniques were mainly applied to dacite reservoir. However, using a single conversion method was not suitable for reservoirs underdeveloped fractures. To address this challenge, we conducted large-scale real-world triaxial simulation test system experiments on hydraulic fracture...
Surface charge graphics endow unspecific porous papers with multifunctional droplet manipulation, which shows great potential for applications in flexible pick-up robots and dynamically controllable fluidic networks.
Pseudomonas aeruginosa bacteremia presents a severe challenge to hospitalized patients. However, date, the risk factors for mortality among inpatients with P. in China remain unclear.This retrospective multicenter study was performed analyze 215 patients culture-confirmed five healthcare centers during years 2012-2019.Of bacteremia, 61 (28.4%) died period. Logistic multivariable analysis revealed that cardiovascular disease (OR=3.978, P=0.001), blood transfusion (OR=5.855, P<0.001) and...
Toxin B (TcdB) is a major exotoxin responsible for diseases associated with Clostridioides difficile infection. Its sequence variations among clinical isolates may contribute to the difficulty in developing effective therapeutics. Here, we investigate receptor-binding specificity of TcdB subtypes (TcdB1 TcdB12). We find that representative members 2, 4, 7, 10, 11, and 12 do not recognize established host receptor, frizzled proteins (FZDs). Using genome-wide CRISPR-Cas9-mediated screen,...
For a cruise ship in heavy sea conditions, self-propulsion performance prediction is important for ensuring its safety. In this study, numerical simulation approach that models the free running of presented, and full-scale small verified using model experiment. Based on method, free-running encountering six kinds wave conditions was simulated, characteristics ship’s motion, added resistance, propeller loading were analyzed. The results demonstrated can simulate self-propelled motion ship, it...
At present, although the ideological and political courses in Colleges anduniversities include practical teaching, there are many problems teaching. Therefore, reform of College Students' Ideological practice teachingmode has become a key research issue. Through teaching mode, wecanenhance attraction course, which will improvetheteaching effect. This paper first analysis importance teachingintheideological course. Then, this puts forward some inpractical Finally, suggestions put forward.
Unresolved inflammation, due to insufficient production of proresolving anti-inflammatory lipid mediators, can lead tumorigenesis. Among these lipoxin A4 (LXA4) has potent anti-carcinogenic properties, and may serve as key target for modulating inflammation-associated cancer like colorectal cancer. The purpose present study was clarify the roles LXA4 in We investigated effects underlying mechanisms its relationship with tumor-associated inflammation immune microenvironment by employing...
Internal pressure is the most important functional load for offshore composite rubber hose. In this paper, stress and radial displacement of hose under internal are investigated. The dimensions length 10.7 m nominal bore diameter 500 mm. structure mainly composed cord-rubber reinforcement layers a spiral steel stiffener. To calculate deformation hose, stiffener theoretically analyzed based on Euler–Bernoulli beam theory Donnell shell theory, respectively. distinguishes from common filament...
Potato common scab, caused mainly by Streptomyces scabies , causes surface necrosis and reduces the economic value of potato tubers, but effective chemical control is still lacking. In this study, an attempt was made to scab inoculating potatoes with Bacillus velezensis ( B. ) further investigate mechanism biological control. The results showed that Y6 could reduce disease severity from 49.92 ± 25.74% [inoculated S. only] 5.56 1.89% (inoculated on same day) increase yield 37.32% compared...
Abstract Clostridioides difficile is a leading cause of healthcare‐associated infections, causing billions economic losses every year. Its symptoms range from mild diarrhea to life‐threatening damage the colon. Transmission and recurrence C. infection (CDI) are mediated by metabolically dormant spores, while virulence mainly due two large clostridial toxins, TcdA TcdB. Producing toxins or forming spores different strategies for cope with harsh environmental conditions. It great significance...
ABSTRACT FeaR is an AraC family regulator that activates transcription of the tynA and feaB genes in Escherichia coli . TynA a periplasmic topaquinone- copper-containing amine oxidase, FeaB cytosolic NAD-linked aldehyde dehydrogenase. Phenylethylamine, tyramine, dopamine are oxidized by to corresponding aldehydes, releasing one equivalent H 2 O NH 3 The aldehydes can be carboxylic acids FeaB, (in case phenylacetate) further degraded enter central metabolism. Thus, phenylethylamine used as...
Synthetic biology has created oscillators, latches, logic gates, logarithmically linear circuits, and load drivers that have electronic analogs in living cells. The ubiquitous operational amplifier, which allows circuits to operate robustly precisely not been built with biomolecular parts. As electronics, a biological operational-amplifier could greatly improve the predictability of despite noise variability, problem all cellular face. Here, we show how create synthetic three-stage...
Many regions in the world are experiencing changes precipitation pattern, which likely impact soil nitrogen cycling and availability. However, we know little about how processes respond to drought stress under climate change. A continuous 5-year experiment of throughfall reduction treatment (TRT) was conducted a Castanopsis hystrix plantation subtropical China assess responded change precipitation. Net transformation, properties, microbial biomass carbon (MBC) (MBN), community phospholipid...
Diverse TcdB variants use a flexible structural platform to tune their specificity toward different GTPase substrates.
Close-to-nature (CTN) forestry integrates multiple forest functions and emphasizes ecosystem conservation. Within this framework, forests are typically maintained as uneven-aged mixed stands with vertical layers managed following the defined stand developmental stages, that is, various phases of succession. This study aimed to evaluate long-term effects CTN management on structure growth Pinus massoniana using data from 28 plots approach 58 traditional monocultures in southern China. A...
Soil enzymes are involved in the process of mineralization soil organic matters. The close-to-nature transformation (CNT) plantations changes enzyme activities by changing composition stand vegetation, which turn affects change carbon. We therefore selected two typical coniferous southwest China, Pinus massoniana and Cunninghamia lanceolate, to explore effects CNT on carbon, relationship between them is explored through comparative study. Compared with control stands (CCK PCK), enhanced...
Abstract As the fields of biotechnology and synthetic biology expand, cheap sensitive tools are needed to measure increasingly complicated genetic circuits. In order bypass some drawbacks optical fluorescent reporting systems, we have designed created a co-culture microbial fuel cell (MFC) system for electronic reporting. This leverages syntrophic growth Escheriachia . coli ( E ) an electrogenic bacterium Shewanella oneidensis MR-1 S ). The fermentative products provide carbon electron...