A5002643577- Antibiotic Resistance in Bacteria
- Pneumonia and Respiratory Infections
- Respiratory viral infections research
- Gut microbiota and health
- Influenza Virus Research Studies
- Antifungal resistance and susceptibility
- Fungal Infections and Studies
- Microfluidic and Capillary Electrophoresis Applications
- Antibiotic Use and Resistance
- Bacterial Identification and Susceptibility Testing
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Childhood Cancer Survivors' Quality of Life
- Microbial infections and disease research
- Analytical Chemistry and Chromatography
- Antimicrobial Resistance in Staphylococcus
- Pneumocystis jirovecii pneumonia detection and treatment
- Antibiotics Pharmacokinetics and Efficacy
- Nosocomial Infections in ICU
- Nitric Oxide and Endothelin Effects
- Tuberculosis Research and Epidemiology
- Pediatric Pain Management Techniques
- Pediatric health and respiratory diseases
- Mycobacterium research and diagnosis
- Infective Endocarditis Diagnosis and Management
- Redox biology and oxidative stress
Chang Gung University of Science and Technology
2009-2023
Linkou Chang Gung Memorial Hospital
2017-2023
China-Japan Friendship Hospital
2016-2023
Chinese Academy of Medical Sciences & Peking Union Medical College
2019-2023
Capital Medical University
2008-2021
Center for Life Sciences
2019-2021
Tsinghua University
2019-2021
Peking University
2019-2021
Xi'an Medical University
2021
Chang Gung Memorial Hospital
2020
It has been shown that thioredoxin (Trx) in a reduced form binds to and inhibits apoptosis signal-regulating kinase 1 (ASK1). Apoptotic stimuli such as tumor necrosis factor (TNF) reactive oxygen species (ROS) activate ASK1 part by oxidizing Trx (forming intramolecular disulfide between C32 C35) release from ASK1. In the present study, we examined if affects protein stability whether redox activity of is critical regulating activity. First, showed overexpression wild-type (Trx-WT)...
The resistance rate of 67 Mycoplasma pneumoniae isolates from 356 ambulatory adult patients with respiratory tract infection was 69% (46 67). All 46 macrolide-resistant strains harbored point mutations in the 23S ribosomal RNA gene. Patients infected M. required significantly longer durations antibiotic therapy and had time to resolution fever.
Although broad knowledge of influenza viral pneumonia has been established, the significance non-influenza respiratory viruses in community-acquired (CAP) and their impact on clinical outcomes remains unclear, especially non-immunocompromised adult population. Hospitalised immunocompetent patients with CAP were prospectively recruited from 34 hospitals mainland China. Respiratory detected by molecular methods. Comparisons conducted between infection groups. In total, 915 out 2336 enrolled...
The inflammatory cytokine TNF-α stimulates several presumed pro-atherogenic signaling events in endothelial cells (ECs), including activation of c-Jun NH2-terminal kinase (JNK) and induction E-selectin. Here, we show that apoptosis signal-regulating 1 (ASK1), a MAP kinase, is required for TNF-mediated JNK activation. TNF activates ASK1 part by dissociating from its inhibitor 14-3-3. Because the risk atherosclerosis decreased regions steady laminar flow, hypothesized flow inhibits...
BackgroundData on symptoms and radiographic changes in patients with pandemic 2009 influenza A(H1N1) (A[H1N1]) pneumonia during convalescence have not been reported.MethodsDuring October 26, 2009, January 23, 2010, adult laboratory-confirmed or clinically suspected infections were observed for clinical characteristics, high-resolution chest CT scan, lung function test acute 3-month convalescent phases.ResultsOf the 65 case subjects, median age was 41 (interquartile range [IQR], 28-57) years,...
Clinical relevance of multilocus variable-number tandem-repeat (VNTR) analysis (MLVA) in patients with community-acquired pneumonia (CAP) by Mycoplasma pneumoniae (M. pneumoniae) is unknown. A multi-center, prospective study was conducted from November 2010 to April 2012. Nine hundred and fifty-four CAP were consecutively enrolled. M. clinical isolates obtained throat swabs. MLVA typing applied all isolates. Comparison severity index (PSI) features among infected different types conducted....
Abstract Background Invasive candidiasis is an important nosocomial infection associated with high mortality among immunosuppressive or critically ill patients. We described the incidence of invasive in our hospital over 6 years and showed antifungal susceptibility genotypes isolated yeast. Method The yeast species were on CHROMagar Candida medium identified using identification card, followed by analysis D1/D2 domain 26S rDNA. susceptibilities isolates to flucytosine, amphotericin B,...
Infections produced by extensively drug-resistant (XDR) gram-negative bacilli (GNB) in solid organ transplant (SOT) are an important cause of morbidity and mortality. Ceftazidime/avibactam (CAZ-AVI) is a novel β-lactam/β-lactamase combination antibiotic with anti-GNB activity, but experience real clinical practice CAZ-AVI lung (LT) recipients limited.We conducted retrospective study patients XDR-GNB infection who received at least 3 days the Department Lung Transplantation Between December...
Abstract Background Resistance to ceftazidime-avibactam was reported , and it is important investigate the mechanisms of ceftazidime/avibactam resistance in K. pneumoniae with mutations bla KPC . Results We report mutated not only mechanism related CZA resistance, role outer porin defects, efflux pump, relative gene expression copy number ompk35/36 Four ceftazidime/avibactam-sensitive isolates detected wild type KPC-2 while 4 ceftazidime/avibactam-resistant ( KPC-51 KPC-52 KPC-33 ). Compared...
We describe in vivo evolution of carbapenem and ceftazidime-avibactam resistance by analyzing four longitudinal Klebsiella pneumoniae clinical isolates from a patient with pneumonia following antimicrobial treatment. The had fever, cough associated expectoration, new infiltration was found on the chest CT. Antimicrobial susceptibility determined, whole genome sequencing (WGS) performed to investigate its dynamic change phenotype. Population analysis profile population . infection started...
Background: Multidrug-resistant (MDR) ST11 hypervirulent Klebsiella pneumoniae (hvKp) is emerging in China. Purpose: The aim of this study was to track the transmission and evolution hvKp. Materials Methods: A retrospective focused on Kp infection conducted. Clinical data were collected from electronic medical records. Whole-genome sequencing strains performed. Single-nucleotide polymorphisms (SNPs) analyzed a map constructed. Sequence type, antimicrobial virulence-associated genes...