A5004514234- Bone Tissue Engineering Materials
- Dental Implant Techniques and Outcomes
- Nicotinic Acetylcholine Receptors Study
- Receptor Mechanisms and Signaling
- biodegradable polymer synthesis and properties
- Collagen: Extraction and Characterization
- Pneumonia and Respiratory Infections
- Orthopaedic implants and arthroplasty
- Electrospun Nanofibers in Biomedical Applications
- Dental materials and restorations
- Periodontal Regeneration and Treatments
- Antibiotic Resistance in Bacteria
- Medical Imaging Techniques and Applications
- Radiopharmaceutical Chemistry and Applications
- Neuroscience and Neuropharmacology Research
- Silk-based biomaterials and applications
- Neurotransmitter Receptor Influence on Behavior
- Tuberculosis Research and Epidemiology
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Ion channel regulation and function
- Graphene and Nanomaterials Applications
- Peptidase Inhibition and Analysis
- Calcium Carbonate Crystallization and Inhibition
- Neuropeptides and Animal Physiology
- Additive Manufacturing and 3D Printing Technologies
Sichuan University
2016-2025
West China Hospital of Sichuan University
2007-2025
Hainan University
2025
Nanjing Medical University
2024
Chengdu University of Traditional Chinese Medicine
2022-2024
Xinjiang University
2024
Kunming Medical University
2024
Johns Hopkins University
2007-2023
Johns Hopkins Medicine
1995-2020
People's Hospital of Cangzhou
2020
A mutation within the obese gene was recently identified as genetic basis for obesity in ob/ob mouse. The product, leptin, is a 16-kDa protein expressed predominantly adipose tissue. Consistent with leptin's postulated role an extracellular signaling protein, human embryonic kidney 293 cells transfected secreted leptin minimal intracellular accumulation. Upon differentiation of 3T3-L1 preadipocytes into adipocytes, mRNA concomitant mRNAs encoding adipocyte marker proteins. factor(s) present...
Severe Community Acquired Pneumonia (SCAP) challenges public health globally. Considerable improvements in molecular pathogen testing emerged the last few years. Our prospective study combinedly used traditional culture, antigen tests, PCR and mNGS SCAP identification with clinical outcomes. From June 2018 to December 2019, we conducted a multi-centre 17 hospitals of patients within 48 hours emergency room stay or hospitalization China. All data were uploaded into an online database. Blood,...
Abstract Purpose: Prostate-specific membrane antigen (PSMA) is a cell surface protein that overexpressed in prostate cancer, including hormone-refractory and metastatic disease. Our goal this study was to develop series of PSMA-based imaging agents for clinical use. Experimental Design: We have synthesized evaluated the vivo biodistribution two radiolabeled urea derivatives high affinity PSMA severe combined immunodeficient mice harboring MCF-7 (breast, PSMA-negative), PC-3 (prostate, LNCaP...
Calcitonin gene-related peptide (CGRP) is a potent neuropeptide whose agonist interaction with the CGRP receptor (CGRP-R) in periphery promotes vasodilation, neurogenic inflammation and trigeminovascular sensory activation. This process implicated cause of migraine headaches, CGRP-R antagonists clinical development have proven effective treating migraine-related pain humans. expressed on blood vessel smooth muscle trigeminal neurons fibers as well central nervous system. However, it not...
Although broad knowledge of influenza viral pneumonia has been established, the significance non-influenza respiratory viruses in community-acquired (CAP) and their impact on clinical outcomes remains unclear, especially non-immunocompromised adult population. Hospitalised immunocompetent patients with CAP were prospectively recruited from 34 hospitals mainland China. Respiratory detected by molecular methods. Comparisons conducted between infection groups. In total, 915 out 2336 enrolled...
Neuronal nicotinic acetylcholine receptors (nAChRs) are ligand-gated ion channels found throughout the central and peripheral nervous systems. They crucial to normal physiology have been clearly implicated in nicotine addiction. In addition, they possible therapeutic targets a wide range of pathological conditions, including cognitive disorders, Parkinson9s disease, neuropathic pain. Nicotinic ligands usually classified as agonists (or partial agonists), competitive antagonists, or...
We conducted active, laboratory-based surveillance for isolates from patients with invasive infections across China August 2009 to July 2010. DNA sequencing methods were used define species, and susceptibility fluconazole voriconazole was determined by the Clinical Laboratory Standards Institute M44-A2 disk diffusion method but using up-to-date clinical breakpoints or epidemiological cutoff values. Candida spp. made up 90.5% of 814 yeast strains isolated, followed Cryptococcus neoformans...
The radiosynthesis of [(18) F]DCFPyL on 2 distinct automated platforms with full regulatory compliant quality control specifications is described. radiotracer synthesis was performed a custom-made radiofluorination module and the Sofie Biosciences ELIXYS. accomplished in an average 66 minutes from end bombardment specific activity at (EOS) 4.4 TBq/μmol (120 Ci/μmol) radiochemical yield 30.9% EOS. ELIXYS completed 87 2.2 (59.3 19% Both modules produced large millicurie quantities while...
α-Conotoxin MII-sensitive nicotinic acetylcholine receptors (nAChRs) are distinct from other subtypes in their relatively restricted localization to the striatum and some brain regions. The effect of nicotine treatment on nAChR has been extensively investigated, with exception changes α-conotoxin receptor expression. We therefore determined consequence long-term administration this subtype its function. Nicotine was given drinking water provide a yet intermittent treatment. Consistent...
Idiopathic pulmonary fibrosis (IPF) is a progressive, lethal, and chronic lung disease. There are no effective drug therapies for IPF. Hyperoside, flavonoid glycoside, has been proven to have anti-inflammatory, anti-fibrosis, antioxidant, anti-cancer effects. The aim of this study was explore the role hyperoside in bleomycin-induced development mice. We established model by single intratracheal aerosol injection bleomycin. Seven days after bleomycin treatment, mice were intraperitoneally...
In 2018, we conducted a cross-sectional study to investigate azole resistance in environmental Aspergillus fumigatus isolates obtained from different agricultural fields China. Using 63 soil cores, cultured for azole-resistant A. and characterized by their cyp51A gene type, short tandem repeat genotype, mating type. Of 206 isolates, 21 (10.2%) were resistant. Nineteen of had mutations (5 TR34/L98H, 8 TR34/L98H/S297T/F495I, 6 TR46/Y121F/T289A). Eighteen samples acquired strawberry fields,...