A5100384234- Pneumonia and Respiratory Infections
- Animal Disease Management and Epidemiology
- Herpesvirus Infections and Treatments
- Animal Virus Infections Studies
- Vector-Borne Animal Diseases
- Viral Infections and Immunology Research
- Chromosomal and Genetic Variations
- Virology and Viral Diseases
- Tuberculosis Research and Epidemiology
- Advanced biosensing and bioanalysis techniques
- Pneumocystis jirovecii pneumonia detection and treatment
- Soil Carbon and Nitrogen Dynamics
- Viral gastroenteritis research and epidemiology
- Antimicrobial Peptides and Activities
- Nosocomial Infections in ICU
- Nerve injury and regeneration
- Viral Infections and Vectors
- Autism Spectrum Disorder Research
- Cancer-related molecular mechanisms research
- Agriculture, Soil, Plant Science
- Biochemical Analysis and Sensing Techniques
- Animal Nutrition and Physiology
- Immune Response and Inflammation
- MicroRNA in disease regulation
- Child Development and Digital Technology
Chinese Academy of Medical Sciences & Peking Union Medical College
2019-2025
Institute of Hematology & Blood Diseases Hospital
2025
Shihezi University
2025
University of Bath
2025
North Minzu University
2020-2025
State Ethnic Affairs Commission
2020-2025
Henan Institute of Science and Technology
2005-2024
National Yang Ming Chiao Tung University
2024
An-Nan Hospital
2024
China Medical University
2024
Brain damage and disease involve activation of microglia production potentially neurotoxic molecules, but there are no treatments that effectively target their harmful properties. We present evidence the small-conductance Ca 2+ /calmodulin-activated K + channel KCNN4/ KCa3.1/SK4/IK1 is highly expressed in rat a potential therapeutic for acute brain damage. Using Transwell cell-culture system allows separate treatment or neurons, we show activated killed this was markedly reduced by treating...
Although broad knowledge of influenza viral pneumonia has been established, the significance non-influenza respiratory viruses in community-acquired (CAP) and their impact on clinical outcomes remains unclear, especially non-immunocompromised adult population. Hospitalised immunocompetent patients with CAP were prospectively recruited from 34 hospitals mainland China. Respiratory detected by molecular methods. Comparisons conducted between infection groups. In total, 915 out 2336 enrolled...
Rapid and accurate detection of pathogenic bacteria is crucial for ensuring food safety public health. In this study, we aimed to develop a novel molecularly imprinted polymer sensor based on screen-printed electrodes the specific Salmonella typhimurium. The was constructed by electropolymerizing dopamine in presence typhimurium electrode surface, followed removal create binding cavities. demonstrated excellent specificity typhimurium, with limit approximately 101 CFU/ml time only 4 min,...
China is facing a shortage of arable land resources, and the mudflat salt-affected soil along east coast an important reserve resource. In this study, we conducted randomized field trial to investigate effects vermicompost application rate (0, 25, 50, 125, 250 t ha−1) on barley growth heavy metal accumulation in soil. We found that decreased bulk density, electrical conductivity (EC), pH while increasing its organic carbon, nitrogen, phosphorus contents. With increase rate, yield grain total...
Background Macrophage polarization and microRNA play crucial roles in the development of atherosclerosis (AS). The M1 macrophage phenotype contributes to formation plaques, while M2 resolves inflammation promotes tissue repair. MiR-126 has been found a role regulating context AS. However, exact mechanism miR-126 requires further research. Methods foam cell model was established by stimulating THP-1 with oxidized low-density lipoprotein (ox-LDL). We transfected cells mimic its negative...
Abstract Nanoparticle-induced autophagy has been extensively studied, however, real time information about the endoplasmic reticulum involved autophagic process (ER autophagy) induced by nanomaterials remains unknown. In this work, silica nanoparticles (SNPs) were synthesized with characteristics of low toxicity, good biocompatibility and excellent water dispersibility to treat cells. Results show that either concentration (10 μg/mL) or high (200 SNPs could increase quantity processing from...
Limited information exists on the clinical characteristics predictive of mortality in patients aged ≥65 years many countries. The impact adherence to current antimicrobial guidelines hospitalized elderly with community-acquired pneumonia (CAP) has never been assessed.
Staphylococcus aureus is a common pathogen that can cause pneumonia and variety of skin diseases. Skin injuries have high risk colonization by S. aureus, which increases morbidity mortality. Due to the emergence multidrug-resistant strains, antimicrobial peptides are considered be among best alternatives antibiotics due their unique mechanism action other characteristics. MPX an antibacterial peptide extracted from wasp venom has activity against bacteria. This study revealed good...
Abstract Plasma membrane Na + /Ca 2+ exchanger 1 (NCX1) is a bidirectional ion transporter to operate in Ca entry or exit modes, and TRPC1 -permeable channel. Both NCX1 play critical roles maintaining cytosolic free ([Ca ] cyt ) homeostasis mammalian cells. Although either channel mode of implicated some tumorigenesis, it has not been explored if coordination involves the pathogenesis H. pylori- associated human gastric cancer (GC). Here we found protein expression was significantly enhanced...
Chicken coccidiosis can cause severe enteritis with high mortality, which causes serious economic losses to the global breeding industry each year. The most virulent strain is Eimeria tenella (E. tenella), but infectivity of different E. varies among geographic strains. At present, there are no reports related pathogenicity and drug resistance in Yiwu, Zhejiang province, China. A total 600 faecal samples were collected from 10 farms overall oocyst prevalence was 54.2% (325/600)....
Abstract The selective oxidation of glycerol to dihydroxyacetone (DHA) represents a critical method for efficiently utilizing glycerol, primary byproduct biodiesel production. However, the challenge balancing catalyst activity and recycling stability significantly limits practical application this process. Herein, conversion performance is effectively modulated by controlling nanostructure support in Au‐supported catalysts. Zinc oxide carriers with morphologies nanorods (NRs), nanoflowers...
Abstract Mono-ADP-ribosyl transferase (mART) proteins are secreted virulence factors produced by several human pathogens, the founding member being diphtheria toxin (DT). Pseudomonas aeruginosa can also secrete a mART toxin, known as exotoxin A (PE), but with an organization of its three functional domains (receptor, translocation, and enzymatic elements) that is opposite to DT. Two additional PE-like toxins (PLTs) have been identified from Vibrio cholerae Aeromonas hydrophila , suggesting...
The usually negative, but variable electrical potential (ψ0) at the cell membrane (CM) surface influences activities of free ions and driving force for transport across CM. rhizotoxic effects uptake Zn2+ Co2+ singly in binary mixture wheat (Triticum aestivum L.) three pH values (4.5, 5.5, or 6.1) were examined terms ion Zn2+, Co2+, H+ CM (these are denoted {Mn+}0). Toxicity to roots better correlated with {M2+}0 than their bulk-phase activities. Studies toxicant interactions using...
Dogs can be used as a translational animal model to close the gap between basic discoveries in rodents and clinical trials humans. The present study compared species-specific properties of satellite glial cells (SGCs) canine murine dorsal root ganglia (DRG) situ vitro using light microscopy, electron immunostainings. expression CNPase, GFAP, glutamine synthetase (GS) has also been investigated simian SGCs. In situ, most SGCs (>80%) expressed neural progenitor cell markers nestin Sox2. CNPase...
Background: Neuropathic pain is one of the common complications after spinal cord injury (SCI), affecting individuals’ quality life. The molecular mechanism for neuropathic SCI still unclear. We aimed to discover potential genes and microRNAs (miRNAs) related by bioinformatics method. Methods: Microarray data GSE69901 were obtained from Gene Expression Omnibus (GEO) database. Peripheral blood samples individuals with or without collected. Twelve 13 as controls included in downloaded...
Escherichia coli can cause intestinal diseases in humans and livestock, destroy the barrier, exacerbate systemic inflammation, seriously threaten human health animal husbandry development. The aim of this study was to investigate whether antimicrobial peptide mastoparan X (MPX) effective against E. infection. BALB/c mice infected with by intraperitoneal injection, which represents a sepsis model. In study, MPX exhibited no toxicity IPEC-J2 cells notably suppressed levels interleukin-6...