A5049496067- COVID-19 Clinical Research Studies
- SARS-CoV-2 and COVID-19 Research
- Long-Term Effects of COVID-19
- Atmospheric chemistry and aerosols
- Pneumonia and Respiratory Infections
- Air Quality and Health Impacts
- Air Quality Monitoring and Forecasting
- Ocular Oncology and Treatments
- Transplantation: Methods and Outcomes
- Tuberculosis Research and Epidemiology
- Chronic Disease Management Strategies
- Acute Lymphoblastic Leukemia research
- RNA modifications and cancer
- Diabetic Foot Ulcer Assessment and Management
- SARS-CoV-2 detection and testing
- Pneumocystis jirovecii pneumonia detection and treatment
- Respiratory viral infections research
- Diabetes and associated disorders
- Chronic Myeloid Leukemia Treatments
- Advanced biosensing and bioanalysis techniques
- Organ and Tissue Transplantation Research
- COVID-19 diagnosis using AI
- Lymphoma Diagnosis and Treatment
- Bone fractures and treatments
- Chronic Obstructive Pulmonary Disease (COPD) Research
Shanghai Jiao Tong University
2015-2025
Soochow University
2014-2025
Shanghai Ninth People's Hospital
2021-2025
Second Affiliated Hospital of Soochow University
2025
Ruijin Hospital
2013-2024
Huazhong University of Science and Technology
2019-2024
Ministry of Ecology and Environment
2020-2024
First Affiliated Hospital of Soochow University
2014-2024
Affiliated Hospital of Youjiang Medical University for Nationalities
2021-2024
Nanjing Drum Tower Hospital
2024
In 1953 Medawar pointed out that survival of the genetically disparate (allogeneic) mammalian conceptus contradicts laws tissue transplantation. Rapid T cell–induced rejection all allogeneic concepti occurred when pregnant mice were treated with a pharmacologic inhibitor indoleamine 2,3-dioxygenase (IDO), tryptophan-catabolizing enzyme expressed by trophoblasts and macrophages. Thus, catabolizing tryptophan, suppresses cell activity defends itself against rejection.
In December 2019, the coronavirus disease 2019 (COVID-19) outbreak occurred in Wuhan. Data on clinical characteristics and outcomes of patients with severe COVID-19 are limited.We sought to evaluate severity admission, complications, treatment, COVID-19.Patients admitted Tongji Hospital from January 26, 2020, February 5, were retrospectively enrolled followed-up until March 3, 2020. Potential risk factors for analyzed by a multivariable binary logistic model. Cox proportional hazard...
Currently, there are no approved specific antiviral agents for novel coronavirus disease 2019 (COVID-19). In this study, 10 severe patients confirmed by real-time viral RNA test were enrolled prospectively. One dose of 200 mL convalescent plasma (CP) derived from recently recovered donors with the neutralizing antibody titers above 1:640 was transfused to as an addition maximal supportive care and agents. The primary endpoint safety CP transfusion. second endpoints improvement clinical...
Rationale: The coronavirus disease (COVID-19) pandemic is now a global health concern.Objectives: We compared the clinical characteristics, laboratory examinations, computed tomography images, and treatments of patients with COVID-19 from three different cities in China.Methods: A total 476 were recruited January 1, 2020, to February 15, at hospitals Wuhan, Shanghai, Anhui. divided into four groups according age (moderate, severe, critical) fifth edition Guidelines on Diagnosis Treatment...
The aim of this study was to further clarify clinical characteristics and predict mortality risk among patients with viral pneumonia.A total 528 pneumonia at RuiJin hospital in Shanghai from May 2015 2019 were recruited. Multiplex real-time RT-PCR used detect respiratory viruses. Demographic information, comorbidities, routine laboratory examinations, immunological indexes, etiological detections, radiological images treatment collected on admission.76 (14.4%) died within 90 days hospital. A...
Severe Community Acquired Pneumonia (SCAP) challenges public health globally. Considerable improvements in molecular pathogen testing emerged the last few years. Our prospective study combinedly used traditional culture, antigen tests, PCR and mNGS SCAP identification with clinical outcomes. From June 2018 to December 2019, we conducted a multi-centre 17 hospitals of patients within 48 hours emergency room stay or hospitalization China. All data were uploaded into an online database. Blood,...
In December 2019, an outbreak of novel coronavirus (2019-nCoV) occurred in Wuhan, Hubei Province, China. By February 14, 2020, it has led to 66 492 confirmed patients China and high mortality up ~2.96% (1123/37 914) Wuhan. Here we report the first family case disease 2019 (COVID-19) Wuhan treated using combination western medicine Chinese traditional patent Shuanghuanglian oral liquid (SHL). This describes identification, diagnosis, clinical course, management three cases from a family,...
The rapid outbreak of coronavirus disease 2019 (COVID-19) has turned into a public health emergency international concern. Epidemiological research shown that sex is associated with the severity COVID-19, but underlying mechanism predisposition remains poorly understood. We aim to study gendered differences in inflammation reaction, and association mortality COVID-19.In this retrospective study, we enrolled 548 COVID-19 inpatients from Tongji Hospital 26 January 5 February 2020, followed up...
The fact that increasing antibiotic resistance of pathogenic bacteria and a lack new potent broad-spectrum antibiotics call for the development alternative approaches treating infectious diseases. With merits great efficacy, safety, facile implementation, antibacterial photodynamic therapy (APDT) represents an attractive modality this purpose. Here, we report newly fabricated chitosan nano-assembly, designated CS-Ce6, could synergistically kill antibiotic-resistant with superior potency to...
Purpose: The first-line chemotherapy treatment protocol for gastric cancer is combination of 5-fluorouracil (5-FU) and cisplatin (CDDP). aim this study was to engineer prodrug-based nanostructured lipid carriers (NLC) platform codelivery 5-FU CDDP enhance therapy decrease toxicity. Methods: First, 5-FU-stearic acid conjugate synthesized by two steps. Second, prodrug were loaded in NLC. Finally, hyaluronic (HA) coated onto NLC surface. Average size, zeta potential, drug loading capacity...
Circular RNAs (circRNAs) are a class of non-coding that could serve as novel biomarkers for the diagnosis and treatment diseases. We hypothesized circRNAs CD4+ T cells involved in asthma.In this study, we investigated circRNA expression profile possible mechanism by which hsa_circ_0005519 participates asthma.The profiles were revealed microarray. Hsa_circ_0005519 was confirmed asthmatic patients (n = 65) healthy subjects 30). Hsa-let-7a-5p, target hsa_circ_0005519, predicted online...
Background Diabetes has been found to increase severity and mortality under the current pandemic of coronavirus disease 2019 (COVID-19). Up date, clinical characteristics diabetes patients with COVID-19 risk factors for poor outcomes are not clearly understood. Methods The study was retrospectively carried out on enrolled laboratory confirmed infection from a designated medical center January 25th, 2020 February 14th, in Wuhan, China. record collected reviewed. Univariate multivariate...
Abstract Backgrounds Stress hyperglycemia ratio (SHR) reflects the acute blood glucose change in response to illnesses or injuries, including pneumonia. We aimed investigate associations of SHR with systemic inflammation and clinical outcomes diabetic inpatients pneumonia on admission. Methods A multicenter retrospective study was conducted among admission via electronic medical records from 2013 2019 Ruijin Hospital, Shengjing China‐Japan Friendship Hospital. Results The included 1631...
Objectives Immune checkpoint inhibitors (ICIs) alone or combined with other antitumor agents are largely used in lung cancer patients, which show both positive effects and side particular subjects. Our study aims to identify biomarkers that can predict response immunotherapy risk of effects, may help us play a role minimize the adverse clinical practice. Methods We retrospectively collected data from patients advanced non-small cell (NSCLC) treated ICIs at our center. Patients who received...
Atrial fibrillation (AF) represents the most common form of sustained cardiac arrhythmia and accounts for substantial morbidity mortality. Increasing evidence demonstrates that abnormal cardiovascular development is involved in pathogenesis AF. In this study, coding exons splice sites NKX2.5 gene, which encodes a homeodomain-containing transcription factor pivotal normal morphogenesis, were sequenced 110 unrelated index patients with familial The available relatives mutation carrier 200...