A5069490653- Viral gastroenteritis research and epidemiology
- Animal Virus Infections Studies
- Virus-based gene therapy research
- RNA Research and Splicing
- Viral Infections and Immunology Research
- RNA and protein synthesis mechanisms
- Viral Infectious Diseases and Gene Expression in Insects
- SARS-CoV-2 and COVID-19 Research
- RNA modifications and cancer
- Herpesvirus Infections and Treatments
- Plant Virus Research Studies
- HIV Research and Treatment
- RNA Interference and Gene Delivery
- Animal Disease Management and Epidemiology
- Radioactive element chemistry and processing
- Virology and Viral Diseases
- Viral-associated cancers and disorders
- Cancer-related molecular mechanisms research
- Cytomegalovirus and herpesvirus research
- MicroRNA in disease regulation
- Animal Genetics and Reproduction
- Xenotransplantation and immune response
- S100 Proteins and Annexins
- Clostridium difficile and Clostridium perfringens research
- Extracellular vesicles in disease
Shanxi University
2020-2025
Donghua University
2025
Center for Infection and Immunity of Lille
2024
Institut Pasteur de Lille
2024
Centre National de la Recherche Scientifique
2024
Centre Hospitalier Universitaire de Lille
2024
Inserm
2024
Shanxi Medical University
2020-2024
Jianghan University
2021-2024
Institute of Vegetables and Flowers
2024
A comprehensive mapping of interactions among Epstein-Barr virus (EBV) proteins and EBV with human should provide specific hypotheses a broad perspective on strategies for replication persistence. Interactions each other were assessed by using stringent high-throughput yeast two-hybrid system. Overall, 43 between 173 identified. EBV-EBV EBV-human protein interaction, or "interactome" maps provided framework function. For example, LF2, an unknown function interacted the immediate early R...
Abstract Electronic skin (E‐skin) is an emerging and promising human‐machine interface. Besides skin‐like functions of tactile perception stretchability, comfortabilities, including breathability, moisture permeability, softness, thermoregulating ability are, also crucial factors for E‐skins. Thermoregulation one the most important roles human skin. People can feel comfortable when their skins are regulated at a certain range temperature. Moreover, it dynamic process according to surrounding...
We present an overview of the Kappa platform, integrated suite analysis and visualization techniques for building interactively exploring rule-based models. The main components platform are Simulator, Static Analyzer Story Extractor. In addition to these components, we describe User Interface, which includes a range interactive tools models needed make sense complexity biological systems. argue that, in this approach, modeling is akin programming can likewise benefit from development...
Two-dimensional (2D) layered materials for environmental remediation require abundant functional groups and high affinity target pollutions. In this work, a heteroatom sulfur-doped graphitic carbon nitride (S3.9%-g-C3N4) material had been fabricated by pyrolysis S- N-rich supramolecular polymer precursor. A hierarchically porous structure with multimodal pore size distribution can facilitate Pb(II) ions' diffusion from wastewater to the S3.9%-g-C3N4 surface. Batch adsorption experiments...
Human TRIM5alpha (TRIM5alpha(hu)) only modestly inhibits human immunodeficiency virus type 1 (HIV-1) and does not inhibit simian (SIV(mac)). Alteration of arginine 332 in the TRIM5alpha(hu) B30.2 domain to proline, residue found rhesus monkey TRIM5alpha, has been shown create a potent restricting factor for both HIV-1 SIV(mac.) Here we demonstrate that potentiation inhibition results from removal positively charged at position TRIM5alpha(hu.) The increase activity correlated with an ability...
The purpose of this study was to examine the occurrence fosfomycin-resistant Escherichia coli from chickens and characterize plasmids carrying fosA3. A total 661 E. isolates chicken origin collected 2009 2011 were screened for plasmid-mediated fosfomycin resistance determinants by PCR. Plasmids characterized using PCR-based replicon typing, plasmid multilocus sequence restriction fragment length polymorphisms. Associated addiction systems genes identified PCR-mapping used analysis genetic...
Abstract C. difficile is a major cause of antibiotic-associated gastrointestinal infections. Two exotoxins (TcdA and TcdB) are virulence factors associated with these infections, chondroitin sulfate proteoglycan 4 (CSPG4) potential receptor for TcdB, but its pathophysiological relevance the molecular details that govern recognition remain unknown. Here, we determine cryo-EM structure TcdB–CSPG4 complex, revealing unique binding site spatially composed multiple discontinuous regions across...
ABSTRACT Epstein-Barr virus (EBV) microRNAs miR-BHRF1-1, -2, and -3 have been detected in latency III-infected lymphoblasts, where they are encoded within EBNA transcripts (X. Cai, A. Schafer, S. Lu, J. P. Bilello, R. C. Desrosiers, Edwards, N. Raab-Traub, B. Cullen, PLoS Pathog. 2: e23, 2006). In we also identified a stable 1.3-kb RNA, which begins 3′ to includes the BHRF1 open reading frame, ends near miR-BHRF1-2. This RNA is residue of Drosha cleavage from transcripts. Early after...
The removal of radionuclides on natural inorganic materials is a pursuing issue for many nuclear-related processes requiring remediation radioactive wastewater. However, the current adsorbents with low cost and great biocompatibility suffer from limitations in efficiency, regeneration capability, or/and operation conditions. Herein, silicon dioxide (SiO2) as major ingredient clay minerals was modified by carboxyl groups to improve its adsorption affinity highly valent radionuclides. batch...
Biosynthesis of sabinene, a bicyclic monoterpene, has been accomplished in engineered microorganisms by introducing heterologous pathways and using renewable sugar as carbon source. However, the efficiency titers this method are limited low host tolerance to sabinene (in both eukaryotes prokaryotes).In study, Escherichia coli BL21(DE3) was selected strain for adaptive laboratory evolution. The evolved serial passaging medium supplemented with gradually increasing concentration XYF(DE3),...
Intrauterine administration of autologous peripheral blood mononuclear cells (PBMCs) activated by HCG in vitro is reported to improve implantation rates patients with repeated failure IVF-ET. In this article, the impact intrauterine PBMCs on embryo implantation, pregnancy rate and underlying mechanisms will be investigated.Pregnant mice were randomly divided into three groups, including control group; dysfunction (EID) EID group. Uterine horns excised determine number pregnant sites Day 7.5...
Helicases contribute to diverse biological processes including replication, transcription and translation. Recent reports suggest that unwinding of some helicases display repetitive activity, yet the functional role repetitiveness requires further investigation. Using single-molecule fluorescence assays, we elucidated a unique mechanism RNA helicase A (RHA) entails discrete substeps consisting binding, activation, unwinding, stalling reactivation stages. This multi-step process is repeated...
Abstract We elucidate the structural evolution of CoN 4 sites during thermal activation by developing a zeolitic imidazolate framework (ZIF)‐8‐derived carbon host as an ideal model for Co 2+ ion adsorption. Subsequent in situ X‐ray absorption spectroscopy analysis can dynamically track conversion from inactive Co−OH and Co−O species into active sites. The critical transition occurs at 700 °C becomes optimal 900 °C, generating highest intrinsic activity four‐electron selectivity oxygen...
RNA helicase A (RHA) has been shown to promote HIV-1 replication at both the translation and reverse transcription stages. prerequisite step for involves annealing of tRNA(3)(Lys), primer transcription, RNA. tRNA(3)(Lys) is a multistep process that initially facilitated by Gag prior viral protein processing. Herein, we report RHA promotes this through increasing quantity annealed ability prime initiation transcription. This improved result an altered conformation produced coordinate action...
RNase MRP is a nucleolar RNA–protein enzyme that participates in the processing of rRNA during ribosome biogenesis. Previous experiments suggested makes nonessential cleavage first internal transcribed spacer. Here we report with new temperature-sensitive mutants Saccharomyces cerevisiae show abundance all early intermediates pathway severely reduced upon inactivation MRP. Transcription continues unabated as determined by RNA polymerase run-on transcription, but precursor transcript does not...