A5100649200- Pancreatic and Hepatic Oncology Research
- Cancer-related molecular mechanisms research
- MicroRNA in disease regulation
- HER2/EGFR in Cancer Research
- Cancer Immunotherapy and Biomarkers
- Immunotherapy and Immune Responses
- Inflammatory Biomarkers in Disease Prognosis
- RNA modifications and cancer
- Peptidase Inhibition and Analysis
- Circular RNAs in diseases
- Lung Cancer Research Studies
- Liver Disease Diagnosis and Treatment
- Biomarkers in Disease Mechanisms
- Cell Adhesion Molecules Research
- Immune cells in cancer
- Acute Myeloid Leukemia Research
- Cancer Treatment and Pharmacology
- Advanced Breast Cancer Therapies
- Lymphoma Diagnosis and Treatment
- Cancer-related gene regulation
- Hepatocellular Carcinoma Treatment and Prognosis
- Cancer, Hypoxia, and Metabolism
- Esophageal Cancer Research and Treatment
- Cancer, Lipids, and Metabolism
- Neurological Disease Mechanisms and Treatments
First Affiliated Hospital of Zhengzhou University
2022-2025
First Affiliated Hospital of Soochow University
2015-2025
West China Hospital of Sichuan University
2022-2025
First Hospital of Jilin University
2021-2025
Jilin University
2021-2025
Soochow University
2015-2025
Sichuan University
2020-2025
Henan Provincial People's Hospital
2011-2024
Zhengzhou University
2015-2024
Henan University
2020-2024
BACKGROUND: Gastric cancer is the fourth most frequent and second cause of cancer-related deaths worldwide. China has a high incidence gastric cancer. Inflammation critical component tumor progression. It been widely accepted that an inflammation-driven In this study, we investigated application value systemic inflammatory response (SIR) markers, platelet to lymphocyte ratio (PLR) neutrophil (NLR), in early diagnosis prognostic prediction patients with resectable MATERIALS AND METHODS: One...
We investigated the mechanism of cancer-associated fibroblasts (CAFs) in promoting invasion and metastasis pancreatic cancer cells a non-vascular manner. verified original generation isolated cultured CAFs normal (NFs) based on expression α-SMA vimentin, we examined cell glycolysis level through glucose consumption lactate production experiments. The mRNA protein CAF glycolytic enzymes, dehydrogenase pyruvate kinase m2, were by RT-PCR western blotting, respectively. In vitro culture...
As the most common subtype of lung cancer, adenocarcinoma (LUAD) is frequently occurred cancers in human. Therefore, thorough investigation necessary for understanding progression LUAD. HMMR has functioned as a regulator some cancers, whereas its biological role still needs to be investigated By bioinformatics analysis, we found that was highly expressed LUAD tissues and associated with patients' poor prognosis. Further, qRT-PCR demonstrated up-regulated cells. Loss-of-function assays...
Chronic cerebral hypoperfusion (CCH) is the leading cause of small vessel disease (CSVD). CCH strongly associated with blood-brain barrier (BBB) dysfunction and white matter lesions (WMLs) in CSVD. However, effects on BBB integrity components cellular molecular mechanisms underlying remain elusive. Whether maintaining can reverse CCH-induced brain damage has also not been explored.In this study, we established a rat model CSVD via permanent bilateral common carotid artery occlusion (2VO) to...
Abstract Background The long‐term trend analysis of esophageal cancer is rarely reported in China. Our purpose to analyze the incidence and mortality trends China from 2005 2015. Method Based on data annual report Cancer Registry, a comprehensive cases deaths 2015 was carried out. are stratified by gender region (urban or rural). Long‐term conducted using Joinpoint regression model. Result In China, age‐standardized rates world population declined 13.84/10 5 11.64/10 Annual percent changes...
Abstract Background Leaves of the natural plant lotus are used in traditional Chinese medicine and tea production. They rich flavonoids. Methods In this study, leaf flavonoids (LLF) were applied to human lung cancer A549 cells small cell H446 vitro verify effect LLF on apoptosis these through ROS/p38 MAPK pathway. Results had no toxic normal at concentrations up 500 µg/mL, but could significantly inhibit proliferation cells. Flow cytometry showed that induce growth We also found increase ROS...
// Qinhong Xu 1 , Zheng Wang Xin Chen Wanxing Duan Jianjun Lei Liang Zong Xuqi Li 3 Sheng Jiguang Ma 2 Han Wei Lun Zhang Kun Guo Zhenhua Wu Erxi 4 and Qingyong Department of Hepatobiliary Surgery, First Affiliated Hospital Medical College, Xi’an Jiaotong University, 710061, Shaanxi, China Oncology, General Pharmaceutical Sciences, North Dakota State Fargo, ND 58105, USA Correspondence: Ma, email: Wang, Keywords : CXCL12/CXCR4 axis, Perineural Invasion, Tumor Microenvironment,...
Ischemia-reperfusion injury is a common early complication after lung transplantation. It was reported that long non-coding RNA (lncRNA) metastasis-associated adenocarcinoma transcript 1 (MALAT1) involved in ischemia-reperfusion and regulates inflammation. This study aimed to explore the role of MALAT1 inflammatory following transplant (LTIR). A LTIR rat model successfully established, with expression interleukin-8 (IL-8) tissues detected. Then, vitro loss- gain-of-function investigations...
CircPVT1 is demonstrated to promote cancer progression in esophageal squamous cell carcinoma (ESCC). However, the role and potential functional mechanisms of circPVT1 regulating 5-fluorouracil (5-FU) chemosensitivity remain largely unknown.ESCC cells resistant 5-FU were induced with continuous increasing concentrations step-wisely. A counting kit-8 assay was used analyze viability ESCC cells. LDH release kit evaluate cytotoxicity. RT-qPCR assess expression level non-coding RNAs cDNAs....
Pancreatic cancer (PC) is a malignancy with poor prognosis and high mortality. Surgical resection the only "curative" treatment. However, minority of patients PC can obtain surgery. Improving overall survival (OS) rate still major challenge. Molecular biomarkers are significant approach for diagnostic predictive use in PCs. Several prediction models have been developed newly diagnosed that operable or advanced metastatic PC; however, these require further validation. Therefore, precise...
Chronic cerebral hypoperfusion (CCH)-triggered blood–brain barrier (BBB) dysfunction is a core pathological change occurring in vascular dementia (VD). Despite the recent advances exploration of structural basis BBB impairment and routes entry harmful compounds after leakage, molecular mechanisms inducing remain largely unknown terms VD. Here, we employed CCH-induced VD model discovered increased cell adhesion molecule 1 (VCAM1) expression on brain endothelial cells (ECs). The VCAM1 was...
The authors used computed tomography (CT) scans to correlate the changes in tumor vascularity, necrosis, and size with response survival after transcatheter arterial chemoembolization (TACE) patients advanced, unresectable, hepatocellular carcinoma (HCC).The studied 72 biopsy-proven, unresectable HCC focused on 186 individual masses. A baseline, multiphase, helical CT was performed at least three follow-up were treatment by TACE. Tumors classified as hypervascular or hypovascular responders...
Gastric cancer is the fourth most frequent and second cause of cancer-related mortalities worldwide. Platelets play an important multifaceted role in progression. Elevated mean platelet volume (MPV) detected peripheral blood has been identified various types cancer. In present study, we investigated application value MPV early diagnostic prognostic prediction patients with resectable gastric total, 168 were included separated into healthy control groups according to median pre-operatic (MPV...
Abstract Temozolomide (TMZ) resistance is the main challenge in management of glioma patients. Heparanase can mediate secretion and function exosomes, which are considered to be a promising molecular delivery system for cancer therapy. Therefore, this study aimed investigate whether heparanase‐mediated exosomes was related TMZ glioma. upregulated TMZ‐resistant cells, overexpression heparanase led increased U87 cells TMZ. Knockdown sensitivity U251 (U251R) promoted from coculture with derived...
Abstract Background Several approaches are being explored for engineering off-the-shelf chimeric antigen receptor (CAR) T cells. In this study, we engineered Fcγ (FcγR) cells and tested their potential as a versatile platform universal cell therapy. Methods Chimeric FcγR (CFR) constructs were generated using three distinct forms of FcγR, namely CD16A, CD32A, CD64. The functionality CFR was evaluated through degranulation assays, specific target lysis experiments, in vitro cytokine production...
740 Background: Pancreatic ductal adenocarcinoma (PDAC) is one of the most lethal cancers with poor prognosis worldwide. Chidamide, a subtype-selective histone deacetylase (HDAC) inhibitor, has significant anti-tumor effects and extensive synergistic immunotherapy. Envafolimab light-chain deficient PD-L1 antibody. Here we conducted single-arm, multicenter, prospective phase Ⅱ clinical study (ChiCTR2200058431) to evaluate efficacy safety Chidamide plus combined S-1 as second-line treatment in...