A5101941645- Cancer-related molecular mechanisms research
- RNA modifications and cancer
- Hepatitis C virus research
- Cardiac Valve Diseases and Treatments
- Congenital Heart Disease Studies
- MicroRNA in disease regulation
- Hepatitis B Virus Studies
- Cardiac Structural Anomalies and Repair
- COVID-19 Clinical Research Studies
- interferon and immune responses
- Liver Disease Diagnosis and Treatment
- Aortic Disease and Treatment Approaches
- Circular RNAs in diseases
- Infective Endocarditis Diagnosis and Management
- Cardiac, Anesthesia and Surgical Outcomes
- Liver physiology and pathology
- Long-Term Effects of COVID-19
- RNA Research and Splicing
- Immune Cell Function and Interaction
- Hemodynamic Monitoring and Therapy
- Pulmonary Hypertension Research and Treatments
- Genetic and Clinical Aspects of Sex Determination and Chromosomal Abnormalities
- Immunotherapy and Immune Responses
- Influenza Virus Research Studies
- Cancer-related gene regulation
China International Science and Technology Cooperation
2020-2025
Lanzhou University
2010-2025
Gansu Provincial Hospital
2017-2025
Yichang Central People's Hospital
2024-2025
Chinese Academy of Medical Sciences & Peking Union Medical College
2025
First Affiliated Hospital of Zhengzhou University
2024
Zhengzhou University
2014-2023
Henan Provincial People's Hospital
2014-2023
Zhengzhou People's Hospital
2013-2023
West China Hospital of Sichuan University
2021
Hepatocellular carcinoma (HCC) is one of the most deadly cancers worldwide and has no effective treatment, yet molecular basis hepatocarcinogenesis remains largely unknown. Here we report findings from a whole-genome sequencing (WGS) study 88 matched HCC tumor/normal pairs, 81 which are Hepatitis B virus (HBV) positive, seeking to identify genetically altered genes pathways implicated in HBV-associated HCC. We find beta-catenin be frequently mutated oncogene (15.9%) TP53 tumor suppressor...
Robin Gasser and his colleagues report the whole-genome sequence of Schistosoma haematobium. They include comparisons to genome sequences S. mansoni japonicum, two other species that cause schistosomiasis in humans. Schistosomiasis is a neglected tropical disease caused by blood flukes (genus Schistosoma; schistosomes) affecting 200 million people worldwide1. No vaccines are available, treatment relies on one drug, praziquantel2. haematobium has come into spotlight as major urogenital...
Ning Li and colleagues report the whole-genome sequence of duck, Anas platyrhynchos, a natural host avian influenza viruses. They examine response to infection by comparing lung transcriptomes ducks that were infected with A The duck (Anas platyrhynchos) is one principal hosts We present genome perform deep transcriptome analyses investigate immune-related genes. Our data indicate possesses contractive immune gene repertoire, as in chicken zebra finch, this repertoire has been shaped through...
The genome of the common roundworm Ascaris suum, a major parasite in many parts world, has now been sequenced. Analyses reveal genes that encode peptidases linked to penetration and degradation host tissues, as well molecules likely modulate or evade immune responses. availability this sequence should contribute towards development new therapeutic interventions against ascariasis other nematode infections. Parasitic diseases have devastating, long-term impact on human health, welfare food...
Liver fibrosis is a common pathologic stage of the development liver failure. It has showed that exosomes loaded with therapeutic circRNAs can be manufactured in bulk by exosome secreted cells vitro, thus enabling personalized treatment. This study aimed to investigate role exosome-based delivery circDIDO1 fibrosis. Levels genes and proteins were examined qRT-PCR Western blot. Cell proliferation, apoptosis, cell cycle analyzed using counting kit-8 (CCK-8) assay, EdU flow cytometry,...
Background The epidermal growth-factor receptor tyrosine kinase inhibitors have been effective in non-small cell lung cancer patients. However, acquired resistance eventually develops most patients despite an initial positive response. Emerging evidence suggests that there is a molecular connection between and the epithelial–mesenchymal transition (EMT). N-cadherin involved EMT metastasis of cells. Here, we analyzed expression function erlotinib-resistant lines. Methods H1650 lines were used...
Accumulating evidence supports that tumor growth and cancer relapse are driven by stem cells. Our previous work has demonstrated the existence of CD90(+) liver cells (CSCs) in hepatocellular carcinoma (HCC). Nevertheless, characteristics these still poorly understood. In this study, we employed a more sensitive RNA-sequencing (RNA-Seq) to compare gene expression profiling sorted from (CD90(+)CSCs) with parallel non-tumorous tissues (CD90(+)NTSCs) elucidate roles putative target genes...
The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has resulted in an ongoing global pandemic of disease 2019 (COVID-19). challenges associated with imaging infected patients have resulted, to date, a paucity metabolic studies COVID-19 infection. Furthermore, it remains unclear if any abnormal events are taking place who recovered from COVID-19.To use [18F] fluorodeoxyglucose ([18F] FDG) positron emission tomography/computed tomography (PET/CT) measure activity inflamed organs...
Ferrets have become an indispensable tool in the understanding of influenza virus virulence and pathogenesis. Furthermore, ferrets are preferred preclinical model for vaccine therapeutic testing. Here we characterized infectome during different stages infectious process with without prior specific immunity to influenza. RNA from lung tissue lymph nodes infected naïve animals was subjected next-generation sequencing, followed by de novo data assembly annotation resulting sequences; this...
ABSTRACT Polyadenylated mature mRNAs are the focus of standard transcriptome analyses. However, profiling nascent transcripts, which often include nonpolyadenylated RNAs, can unveil novel insights into transcriptional regulation. Here, we separately sequenced total RNAs (Total RNAseq) and (mRNAseq) from same HIV-1-infected human CD4 + T cells. We found that many were differentially expressed upon HIV-1 infection, identified 8 times more genes at 12 h postinfection by Total RNAseq than...
Heart auscultation is a convenient tool for early diagnosis of heart diseases and being developed to be an intelligent used in online medicine. Currently, there are few studies on pediatric murmurs due congenital disease (CHD). The purpose the study was develop method CHD murmurs. Phonocardiogram (PCG) signals 86 children were recorded with 24 having normal sounds 62 A segmentation based discrete wavelet transform combined Hadamard product implemented locate first second from PCG signal. Ten...
ABSTRACT Background Breast cancer (BC) and lung are the two most common malignancies among women in China. As breast diagnostic therapeutic technologies continue to advance, lifespan of patients with has been extended, number second primary (SPLC) increased. Furthermore, SPLC, stands as prevalent initial malignancy, SPLC remains predominant cause mortality within this demographic. The aim retrospective study was analyze clinical characteristics investigate postoperative survival prognostic...
Gene discovery in the Malaysian giant freshwater prawn (Macrobrachium rosenbergii) has been limited to small scale data collection, despite great interest various research fields related commercial significance of this species. Next generation sequencing technologies that have developed recently and enabled whole transcriptome (RNA-seq), allowed large functional genomics sets a shorter time than was previously possible. Using technology, three tissue types: hepatopancreas, gill muscle,...
Abstract: In the previous study, it was found that long intergenic noncoding RNA-p21 (lincRNA-p21) downregulated in hepatocellular carcinoma (HCC) and lincRNA-p21 overexpression inhibited tumor invasion through inducing epithelial–mesenchymal transition. However, underlying mechanism not fully elaborated. this expression measured 12 paired HCC nontumor adjacent normal tissues by quantitative real-time polymerase chain reaction. The effects of on cells were studied using lentivirus...