A5025671045- Influenza Virus Research Studies
- Acupuncture Treatment Research Studies
- Immune Response and Inflammation
- Traditional Chinese Medicine Studies
- Healthcare and Venom Research
- Energy Load and Power Forecasting
- Power Transformer Diagnostics and Insulation
- Respiratory viral infections research
- interferon and immune responses
- Advanced Algorithms and Applications
- Viral gastroenteritis research and epidemiology
- Machine Fault Diagnosis Techniques
- Animal Virus Infections Studies
- Smart Grid and Power Systems
- Immune Cell Function and Interaction
- Medical Research and Treatments
- Oil and Gas Production Techniques
- Computational Drug Discovery Methods
- Engineering Structural Analysis Methods
- Image and Signal Denoising Methods
- SARS-CoV-2 and COVID-19 Research
- Advanced Antenna and Metasurface Technologies
- High voltage insulation and dielectric phenomena
- Pharmacological Effects of Natural Compounds
- Power Systems and Renewable Energy
Wuhan University
2005-2025
China Aerodynamics Research and Development Center
2025
Capital Medical University
2020-2024
Beijing Hospital of Traditional Chinese Medicine
2020-2024
Nanchang Institute of Technology
2022-2024
State Key Laboratory of Water Resources and Hydropower Engineering Science
2024
Northwest A&F University
2023
National Center for Women and Children’s Health, China CDC
2022-2023
Beijing Institute of Neurosurgery
2023
Beijing University of Chemical Technology
2015-2022
ABSTRACT It is not understood how immune inflammation influences the pathogenesis of severe acute respiratory syndrome (SARS). One area strong controversy role interferon (IFN) responses in natural history SARS. The fact that majority SARS patients recover after relatively moderate illness suggests prevailing notion deficient type I IFN-mediated immunity, with hypercytokinemia driving a poor clinical course, oversimplified. We used proteomic and genomic technology to systematically analyze...
ABSTRACT How viral and host factors contribute to the severe pathogenicity of H5N1 subtype avian influenza virus infection in humans is poorly understood. We identified three clusters differentially expressed innate immune response genes lungs from (A/Vietnam/1203/04) virus-infected ferrets by oligonucleotide microarray analysis. Interferon were more strongly H5N1-infected ferret than infected with less pathogenic H3N2 subtype. In particular, robust CXCL10 gene expression led us test role...
Pandemic H1N1 influenza A (H1N1pdm) is currently a dominant circulating strain worldwide. Severe cases of H1N1pdm infection are characterized by prolonged activation the immune response, yet specific role inflammatory mediators in disease poorly understood. The cytokine IL-6 has been implicated both seasonal and severe pandemic infection. Here, we investigated We found to be an important feature host response humans mice infected with H1N1pdm. Elevated levels were associated patients...
Influenza A and B infections are a worldwide health concern to both humans animals. High genetic evolution rates of the influenza virus allow constant emergence new strains cause illness variation. Since human often complicated by secondary factors such as age underlying medical conditions, strain or subtype specific clinical features difficult assess. Here we infected ferrets with 13 currently circulating (including pandemic 2009 H1N1 [H1N1pdm] seasonal A/H1N1, A/H3N2, viruses). The...
In terms of its highly pathogenic nature, there remains a significant need to further define the immune pathology SARS-coronavirus (SARS-CoV) infection, as well identify correlates immunity help develop vaccines for severe coronaviral infections. Here we use SARS-CoV infection-reinfection ferret model and functional genomics approach gain insight into SARS immunopathogenesis protection during SARS-CoV-challenge in ferrets previously infected with or immunized virus vaccine. We identified...
Genome sequencing has provided us with gene lists but cannot tell where and how their encoded products work together to support life. Complex organisms rely on differential expression of subsets genes/proteins in organs tissues, and, concert, evolved present state as they function improve an organism's overall reproductive fitness. Proteomics studies individual help understand basic functions, this reductionist approach misses the larger context whole organism. This problem could be...
Dissolved gas analysis (DGA) is a widely used method for transformer internal fault diagnosis. However, the traditional DGA technology, including Key Gas method, Dornenburg ratio Rogers International Electrotechnical Commission (IEC) three-ratio and Duval triangle etc., suffers from shortcomings such as coding deficiencies, excessive boundaries critical value criterion defects, which affect reliability of analysis. Grey wolf optimizer (GWO) novel swarm intelligence optimization algorithm...
With the continuous operation of analog circuits, component degradation problem gradually comes to forefront, which may lead problems, such as circuit performance degradation, system stability reductions, and signal quality could be particularly evident in increasingly complex electronic systems. At same time, due factors, transformation, fluctuation parameters, nonlinear characteristics components, traditional fault localization methods are still facing significant challenges when dealing...
In complex industrial environments, limited data availability poses significant challenges for rotating machinery fault diagnosis. This paper proposes a novel multi-scale dense residual shrinkage generative adversarial network (MDRS-GAN) to address diagnosis under small sample and imbalanced conditions. The framework introduces three key innovations: (1) A hierarchical multi-head attention generator (HMHA-MSG) is developed dynamically fuse process features, thereby enhancing distribution...
Turbine rotors are susceptible to bolt loosening and detachment due factors such as vibration, stress concentration, material degradation during the prolonged operation of hydropower units. These issues can result in significant safety incidents economic losses. This article presents a novel vision-based automatic detection method for identifying loose bolts turbine by analyzing angle between marking lines on top surfaces studs nuts. The proposed integrates enhanced you only look once...
To address the challenge of extracting adaptive fault features for unmanned aerial vehicle (UAV) rotor motor bearings and to meet high accuracy requirements bearing diagnosis, this paper proposes a neural network-based diagnosis method using WPT-CEEMD-CNN-LSTM. Initially, applies multiple noise reduction processes original vibration signals enhances their time–frequency resolution through Wavelet Packet Transform (WPT) Complete Ensemble Empirical Mode Decomposition (CEEMD). This effectively...
The foodborne pathogen Salmonella triggers distinct phosphorylation events in host cells to promote infection.
ABSTRACT Young children are typically considered a high-risk group for disease associated with influenza virus infection. Interestingly, recent clinical reports suggested that young were the smallest of cases severe pandemic 2009 H1N1 (H1N1pdm) Here we established newly weaned ferret model investigation H1N1pdm infection in age groups compared to adults. We found ferrets had significantly milder fever and less weight loss than adult ferrets, which paralleled mild symptoms younger humans....
During the 2009 H1N1 influenza virus pandemic (pdmH1N1) outbreak, it was found that most individuals lacked antibodies against new pdmH1N1 virus, and only elderly showed anti-hemagglutinin (anti-HA) were cross-reactive with strains. Different studies have demonstrated prior contact can confer protection strains some degree of dissimilarity; however, this has not been sufficiently explored within context a infection. In study, we first infection A/Brisbane/59/2007 strain confers heterologous...
Ferrets have become an indispensable tool in the understanding of influenza virus virulence and pathogenesis. Furthermore, ferrets are preferred preclinical model for vaccine therapeutic testing. Here we characterized infectome during different stages infectious process with without prior specific immunity to influenza. RNA from lung tissue lymph nodes infected naïve animals was subjected next-generation sequencing, followed by de novo data assembly annotation resulting sequences; this...
ABSTRACT The 2009 H1N1 influenza pandemic has prompted a significant need for the development of efficient, single-dose, adjuvanted vaccines. Here we investigated adjuvant potential CpG oligodeoxynucleotide (ODN) when used with human seasonal virus vaccine in ferrets. We found that ODN-adjuvanted effectively increased antibody production and activated type I interferon (IFN) responses compared to alone. Based on these findings, pegylated IFN-α2b (PEG-IFN) was also evaluated as an comparison...
Many Gram-negative bacteria colonize and exploit host niches using a protein apparatus called type III secretion system (T3SS) that translocates bacterial effector proteins into cells where their functions are essential for pathogenesis. A suite of T3SS-associated chaperone bind cargo in the cytosol, establishing interaction networks needed translocation cells. In Salmonella enterica serovar Typhimurium, T3SS encoded large genomic island (SPI-2) is required intracellular infection, but...
The condition monitoring and fault diagnosis of power transformers plays a significant role in the safe, stable reliable operation whole system. Dissolved gas analysis (DGA) methods are widely used for diagnosis, however, their accuracy is limited by selection DGA features performance models, example, classical support vector machine (SVM), easily affected unbalanced training samples. This paper presents transformer model based on chemical reaction optimization twin machine. Twin machines...
The use of ribavirin in influenza treatment is a matter debate. Due to adamantine- and oseltamivir-resistant strains the current pandemic H1N1 (pdmH1N1) viruses, demand for alternative antiviral treatments has increased. This study demonstrated potent effects mouse model pdmH1N1 infection (A/Mexico/4108/2009). It was found that with 40 mg kg−1 day−1 partially protected animals if initiated immediately upon infection. Administration similar concentrations on subsequent days or immediate...