A5102993837- Influenza Virus Research Studies
- Respiratory viral infections research
- Pneumonia and Respiratory Infections
- Bacterial Infections and Vaccines
- Vaccine Coverage and Hesitancy
- Clostridium difficile and Clostridium perfringens research
- Viral gastroenteritis research and epidemiology
- Bacterial Identification and Susceptibility Testing
- SARS-CoV-2 and COVID-19 Research
- Infectious Encephalopathies and Encephalitis
- Virology and Viral Diseases
- Cardiac Arrest and Resuscitation
- Herpesvirus Infections and Treatments
- Retinal and Optic Conditions
- Respiratory Support and Mechanisms
- Neonatal and Maternal Infections
- Nosocomial Infections in ICU
- Urinary Tract Infections Management
- Emergency and Acute Care Studies
- Cystic Fibrosis Research Advances
- Antimicrobial Resistance in Staphylococcus
- COVID-19 epidemiological studies
- Streptococcal Infections and Treatments
- Immune Response and Inflammation
- vaccines and immunoinformatics approaches
Oregon Health Authority
2018-2025
New York Proton Center
2023
Communities In Schools of Orange County
2023
Manhattan Institute for Policy Research
2023
Oregon Medical Research Center
2023
Lindsay Unified School District
2023
Hospital for Sick Children
2010-2022
University of Toronto
2008-2018
Institute for Clinical Evaluative Sciences
2011-2018
Public Health Ontario
2011-2018
<b>Background:</b> Limited data are available on disease characteristics and outcomes of children with 2009 pandemic influenza A(H1N1) virus infection (pandemic H1N1 influenza) who have required hospital admission. <b>Methods:</b> We reviewed the charts 58 admitted to a large pediatric in Ontario, Canada, between May 8 July 22, 2009. compared risk factors, severity indicators these those 200 seasonal A during previous 5 years (2004/05 2008/09). <b>Results:</b> Children were significantly...
"Vaccine hesitancy" is a concept now frequently used in vaccination discourse. The increased popularity of this both academic and public health circles challenging previously held perspectives that individual attitudes behaviours are simple dichotomy accept or reject. A consultation study was designed to assess the opinions experts professionals concerning definition, scope, causes vaccine hesitancy Canada. We sent online surveys two panels (1- 2- front-line providers). Two questionnaires...
Pandemic H1N1 influenza A (H1N1pdm) is currently a dominant circulating strain worldwide. Severe cases of H1N1pdm infection are characterized by prolonged activation the immune response, yet specific role inflammatory mediators in disease poorly understood. The cytokine IL-6 has been implicated both seasonal and severe pandemic infection. Here, we investigated We found to be an important feature host response humans mice infected with H1N1pdm. Elevated levels were associated patients...
The extent to which influenza A and B infection differs remains uncertain.Using active surveillance data from the Canadian Immunization Monitoring Program Active at 12 pediatric hospitals, we compared clinical characteristics outcomes of children ≤16 years admitted with laboratory-confirmed or seasonal A. We also examined factors associated ICU admission in hospitalized B.Over 8 nonpandemic seasons (2004-2013), identified 1510 2645 cases; median ages were 3.9 2.0 years, respectively (P <...
Background. Neisseria meningitidis causes 500 000 cases of septicemia and meningitis worldwide annually, with approximately 200 in Canada each year. Previous studies describe a case-fatality rate 5%–15% up to 20% survivors suffering from long-term disability.
In patients with invasive pneumococcal disease who have been previously exposed to antibiotics, the time elapsed from end of most recent treatment course appears be important factor predicting antimicrobial resistance.
Maternal vaccination is an important area of research and requires appropriate internationally comparable definitions safety standards. The GAIA group, part the Brighton Collaboration was created with mandate proposing standardised applicable to maternal vaccine research. This study proposes international for neonatal infections. infections working group performed a literature review using Medline, EMBASE Cochrane collaboration collected in use public health networks. common criteria derived...
Abstract Background Antimicrobial use surveillance data within National Healthcare Safety Network (NHSN) uses patient care location mapping to define locations and inform risk adjustment. During the COVID-19 public health emergency, many hospitals changed how beds were utilized. This study compares changes over time a statewide hospital antimicrobial stewardship collaborative during emergency.Figure 1.Frequency of Facilities by Change in Total Beds from 2019 In this analysis, each facility's...
Abstract Background Acute respiratory tract infections (ARTIs) often lead to antibiotic prescriptions in outpatient settings, many of which are unnecessary. Inappropriate prescribing antibiotics contributes the emergence resistance. Antibiotic surveillance related ARTIs is important for identifying diagnoses and populations stewardship efforts needed. The purpose this study was describe trends settings Oregon, both before during COVID-19 public health emergency. Methods We queried medical...
Recent increases in pertussis morbidity and mortality rates among young infants have led to a recommendation some countries for vaccination against during pregnancy. Having data on the burden of pediatric large population over time is important establishing true disease acellular (aP) vaccine era. Here, we describe age-specific epidemiology children hospitalized with 17 years across Canada aP
Objectives. A number of studies have looked at the role infectious diseases in triggering juvenile dermatomyositis (JDM). Previous found a moderately high frequency symptoms prior to disease onset; however, no specific pathogens could be identified. We sought correlate preceding with onset and outcomes JDM. Methods. studied an inception cohort all JDM cases diagnosed The Hospital for Sick Children (SickKids) between 1988 2006. Data pertaining onset, diagnosis were abstracted. Two independent...
Background. Before 2001, the incidence of invasive meningococcal disease (IMD) in Canada was 1.0 per 100 000 year, with 40% cases caused by serogroup C organisms. During 2001–2005 all provinces introduced conjugate vaccine (MCCV) into their routine infant immunization schedule. Methods. Active, prospective, population-based surveillance IMD children and adults conducted Canadian Immunization Monitoring Program, ACTive (IMPACT) during 2002–2012. Inclusion criteria were admission to hospital...
BACKGROUND: The rapidly evolving pandemic of novel 2009 swine-origin influenza A (H1N1) virus (S-OIV) demands that accurate and practical diagnostics be urgently evaluated for their potential clinical utility. OBJECTIVE: To determine the diagnostic accuracy a rapid test (RIDT) direct fluorescent antibody (DFA) assay S-OIV by using reverse-transcription polymerase chain reaction (RT-PCR) as reference standard. METHODS: We prospectively recruited children (aged 0–17 years) assessed in...
Studies have identified certain neurologic and neurodevelopmental conditions (NNC) as risk factors for severe influenza infection. The Canadian National Advisory Committee on Immunization does not currently recognize children with NNC having a high of complicated infection unless their condition compromises handling respiratory secretions. We describe the burden in hospitalized NNC, focusing those without potential airway compromise.Using multi-year surveillance data obtained by Monitoring...
Uncertainty remains regarding the magnitude of effectiveness influenza vaccines for preventing serious outcomes, especially among young children. We estimated vaccine (VE) against laboratory-confirmed hospitalizations children aged 6-59 months. used test-negative design in hospitalized Ontario, Canada during 2010-11 to 2013-14 seasons. logistic regression models adjusted age, season, and time within season calculate VE estimates by vaccination status (full vs. partial), age group, season....