A5043472782- Bacterial Infections and Vaccines
- Pneumonia and Respiratory Infections
- Influenza Virus Research Studies
- Respiratory viral infections research
- Vaccine Coverage and Hesitancy
- Hepatitis B Virus Studies
- Hepatitis Viruses Studies and Epidemiology
- SARS-CoV-2 and COVID-19 Research
- Immunodeficiency and Autoimmune Disorders
- Viral gastroenteritis research and epidemiology
- Herpesvirus Infections and Treatments
- Virology and Viral Diseases
- Antimicrobial Resistance in Staphylococcus
- Infectious Encephalopathies and Encephalitis
- Immune Response and Inflammation
- Pneumocystis jirovecii pneumonia detection and treatment
- Bartonella species infections research
- Neonatal Respiratory Health Research
- Streptococcal Infections and Treatments
- Intramuscular injections and effects
- Neonatal and Maternal Infections
- Child and Adolescent Health
- Viral Infections and Immunology Research
- Infective Endocarditis Diagnosis and Management
- Blood groups and transfusion
British Columbia Children's Hospital
2011-2022
University of British Columbia
2011-2020
Dalhousie University
1999-2020
Research Network (United States)
2020
Izaak Walton Killam Health Centre
1999-2020
Nova Scotia Health Authority
2020
Université de Montréal
2020
McGill University Health Centre
2020
University of Calgary
2016-2020
Child and Family Research Institute
2010-2017
CANCER ISthe second most common cause of cancer morbidity and mortality in women. 1 Human papillomavirus (HPV) infection has been identified as a necessary for the development cervical cancer, with HPV genotypes 16 18 accounting approximately 70% cases.Prevention using either bivalent (HPV-16 HPV-18) or quadrivalent (HPV-6, HPV-11, HPV-16, vaccine is goal immu-
Routine infant vaccination with 7-valent pneumococcal conjugate vaccine (PCV7) began in the Calgary Health Region (Alberta, Canada) 2002. We measured impact of this program on invasive disease (IPD).Prospective, population-based surveillance all cases IPD (with culture specimens obtained from sterile sites) was conducted January 1998 through December 2007. Demographic and clinical data were collected. All viable isolates saved serotyped.There 1182 over 10-year period. Comparison period...
Two different severe acute respiratory syndrome (SARS) vaccine strategies were evaluated for their ability to protect against live SARS coronavirus (CoV) challenge in a murine model of infection. A whole killed (inactivated by beta-propiolactone) SARS-CoV and combination two adenovirus-based vectors, one expressing the nucleocapsid (N) other spike (S) protein (collectively designated Ad S/N), induction serum neutralizing antibodies cellular immune responses pulmonary replication. The virus...
The extent to which influenza A and B infection differs remains uncertain.Using active surveillance data from the Canadian Immunization Monitoring Program Active at 12 pediatric hospitals, we compared clinical characteristics outcomes of children ≤16 years admitted with laboratory-confirmed or seasonal A. We also examined factors associated ICU admission in hospitalized B.Over 8 nonpandemic seasons (2004-2013), identified 1510 2645 cases; median ages were 3.9 2.0 years, respectively (P <...
To assess the morbidity associated with continued high levels of pertussis, we studied all children .2 years age who were admitted to 11 Immunization Monitoring Program-Active (IMPACT) centers, which constitute 85% Canada's tertiary care pediatric beds. In 7 preceding implementation acellular pertussis vaccine, a total 1,082 cases reported, 49.1% culture-confirmed. The median patients was 12.4 weeks; 78.9% in <6 months age. Complications common: pneumonia reported 9.4% cases, new seizures...
Necrotizing enterocolitis (NEC) is a serious neonatal disorder of uncertain cause, although fecal bacteria have been implicated in some outbreaks. We examined coagulase-negative staphylococci (CONS) as possible etiologic agents. In our unit, CONS colonized the bowels most infants studied, including 46% 70 NEC cases (mean concentration, 10(9.1) CFU/g stool). Over 90% tested isolates produced hemolysin resembling delta toxin Staphylococcus aureus. Toxin purified from NEC-associated isolate...
Background. Cases of infection due to a novel swine-origin variant influenza A virus subtype H3N2 (H3N2v) have recently been identified in the United States, primarily among children. We estimate levels cross-reactive antibody H3N2v by age and assess whether seasonal trivalent inactivated vaccine (TIV), with or without adjuvant, may increase seroprotection. Methods. Antibody was assessed hemagglutination inhibition (HI) assay and, for subset, also microneutralization assay. Seroprevalence...
In collaboration with the Canadian Immunization Monitoring Program Active (IMPACT), National Microbiology Laboratory, UK Health Protection Agency and Novartis Vaccines, we tested potential of an investigational 4-component meningococcal B vaccine (4CMenB) to cover strains circulating from 2006 2009.IMPACT surveillance is population based includes over 50% adults children. All isolates were characterized by Meningococcal Antigen Typing System (MATS) sequencing for factor H-binding protein...
Background. Neisseria meningitidis causes 500 000 cases of septicemia and meningitis worldwide annually, with approximately 200 in Canada each year. Previous studies describe a case-fatality rate 5%–15% up to 20% survivors suffering from long-term disability.
Objective. Acellular pertussis vaccines were introduced with the promise of an improved safety profile compared whole-cell vaccines. In 1997–1998, Canada adopted 1 combination acellular vaccine, having previously used particular vaccine. We hypothesized that change would result in a decrease hospitalization rates for seizures and reports hypotonic-hyporesponsive episodes (HHEs) temporally related to vaccination. Methods. Active surveillance was performed between 1995 2001 by Immunization...
OBJECTIVES. Influenza is a common childhood infection that may result in hospitalization. Our objectives were to (1) determine characteristics of children hospitalized for influenza and disease manifestations (2) obtain baseline data before implementation new recommendations routine immunization young their caretakers against influenza. METHODS. All the with laboratory-confirmed at 9 Canadian tertiary care hospitals during 2003–2004 season identified from virology laboratory reports, charts...
Background: Haemophilus influenzae type b (Hib) immunization has changed the epidemiology of pediatric bacterial invasive disease. We describe H. infections in 12 Canadian tertiary care [Immunization Monitoring Program, ACTive (IMPACT)] centers during era universal against this pathogen. Methods: Children with positive cultures for serotypes a to f (Hia Hif) and nontypable from sterile sites were identified laboratory records at IMPACT January 1, 1996 December 31, 2001. Hospital...
Objective Pain response may be altered in infants born very preterm owing to repeated exposure procedures the neonatal intensive care unit. Findings have been inconsistent studies of behavioral and cardiac responses brief pain versus full-term following unit discharge. To our knowledge, cortisol reactivity has not compared infants. We examined immunization Method Cortisol, facial behavior, heart rate before, during, after were at extremely low gestational age (ELGA 24 28 wk), (VLGA 29 32...
We assessed whether 2 full versus half-doses of trivalent inactivated influenza vaccine (TIV) could improve immunogenicity without increasing reactogenicity in infants (aged 6-11 months) and toddlers 12-23 months).Previously unimmunized were separately randomly assigned to receive (0.5-mL) or half (0.25-mL) doses 2008-2009 split TIV. Sera collected at enrollment 27 45 days after the second injection. Parents recorded adverse events each The primary outcome was superiority (1-sided, α =...
Background: Conjugate meningococcal vaccines may decrease the incidence of disease. The staggered implementation universal childhood C conjugate (MenC) immunization programs across Canada offers an opportunity to evaluate influence these programs. Methods: From 2002 2006, we conducted active, population-based surveillance for adult and pediatric hospital admissions related infections at 12 centers Canadian Immunization Monitoring Program, Active (IMPACT), in collaboration with local public...
Abstract Background Fewer Canadian seniors are vaccinated against pneumococcal disease than receive the influenza vaccine annually. Improved understanding of factors influencing vaccination among older adults is needed to improve uptake. Methods A self-administered survey measuring knowledge, attitudes, beliefs and behaviours about was administered a cohort participating in clinical trial seasonal vaccines at eight centers across Canada. Eligible participants were ambulatory 65 years age or...
Invasive meningococcal disease remains a rare but deadly infection in Canada. New serogroup B vaccines may offer the potential for prevention and control. This report examines burden caused by invasive infections.From 2002 to 2011, active, population-based metropolitan area surveillance adult pediatric hospital admissions laboratory-confirmed with Neisseria meningitidis, was conducted 12 centers of Canadian Immunization Monitoring Program, Active.A total 769 cases occurred from 2011; 54% (n...