A5041854540- Pneumonia and Respiratory Infections
- Respiratory viral infections research
- Bacterial Infections and Vaccines
- Vaccine Coverage and Hesitancy
- Pneumocystis jirovecii pneumonia detection and treatment
- SARS-CoV-2 and COVID-19 Research
- Influenza Virus Research Studies
- Streptococcal Infections and Treatments
- Emergency and Acute Care Studies
- Child and Adolescent Health
- Hepatitis B Virus Studies
- Otolaryngology and Infectious Diseases
- Immunodeficiency and Autoimmune Disorders
- Antimicrobial Resistance in Staphylococcus
- Infective Endocarditis Diagnosis and Management
- COVID-19 Impact on Reproduction
- Pharmaceutical and Antibiotic Environmental Impacts
- Respiratory and Cough-Related Research
- Antibiotic Use and Resistance
- COVID-19 Clinical Research Studies
- Cervical Cancer and HPV Research
- Heart Failure Treatment and Management
- Viral gastroenteritis research and epidemiology
- Pediatric health and respiratory diseases
- Respiratory Support and Mechanisms
University of Calgary
2016-2025
Alberta Health Services
2010-2025
Alberta Children's Hospital
2015-2024
Research Network (United States)
2024
Universitätsklinikum Würzburg
2024
Alberta Children's Hospital Research Institute
2014-2023
Brown University
2022
Peter Doherty Institute
2022
The Royal Melbourne Hospital
2022
Hôpital d'Enfants
2021
Routine infant vaccination with 7-valent pneumococcal conjugate vaccine (PCV7) began in the Calgary Health Region (Alberta, Canada) 2002. We measured impact of this program on invasive disease (IPD).Prospective, population-based surveillance all cases IPD (with culture specimens obtained from sterile sites) was conducted January 1998 through December 2007. Demographic and clinical data were collected. All viable isolates saved serotyped.There 1182 over 10-year period. Comparison period...
Chronic recurrent multifocal osteomyelitis (CRMO) is an inflammatory, non-infectious osteopathy that affects predominantly patients </= 18 years of age. There no uniformly effective treatment. Our objective to describe clinical, magnetic resonance imaging (MRI), and bone resorption response intravenous pamidronate in pediatric CRMO.We report our prospectively documented experience with all CRMO treated between 2003 2008 at a tertiary centre. Pamidronate was administered as cycles. The dose...
Respiratory syncytial virus, the most common cause of bronchiolitis, is leading infant hospitalization in developed countries and accounts for substantial mortality morbidity developing countries. Children at increased risk severe bronchiolitis are those <6 weeks age, born prematurely with an underlying cardiopulmonary disorder or immunodeficiency. Approximately 80% cases occur first year life. By two years virtually all children have been infected by least one strain virus. Classically,...
Of a total of 147 erythromycin-resistant Streptococcus pneumoniae isolates, 64 (43.5%) were resistant to erythromycin, clindamycin, and streptogramin B (MLSB phenotype), 57 which possessed the ermB gene. Eighty-two (55.8%) erythromycin alone (M 81 mefE One was but susceptible clindamycin (MS phenotype) neither erm gene nor
Antibiotic resistance is associated with prior receipt of antibiotics. An analysis linked computerized databases for physician visits and antibiotic prescriptions was used to examine prescribing different respiratory infections in preschool children Canada. In 1995, 64% 61,165 aged <5 years made 140,892 (mean, 3.6 per child) infections; 74% who received prescriptions. Antibiotics were prescribed 49% upper tract infection, 18% nasopharyngitis, 78% pharyngitis or tonsillitis, 32% serous otitis...
To determine the effectiveness of glucocorticoid treatment in children with croup.Meta-analysis randomized controlled trials that examine croup.Score on scale measuring severity croup,use co-interventions (epinephrine, antibiotics, or supplemental glucocorticoids), length stay emergency department hospital, and rate hospitalization.Twenty-four studies met inclusion criteria. Glucocorticoid was associated an improvement croup score at 6 hours effect size -1.0 (95% confidence interval [CI]...
SUMMARY Large-scale population-based studies have reported a significant increase in invasive pneumococcal disease (IPD) those with underlying haematological or solid-organ malignancy, but limited condition-specific data are available on rates of IPD the adult population. A retrospective chart review all patients (identified prospectively) province Alberta, Canada (population ~3·3 million) was conducted from 2000 to 2004 study epidemiology IPD. Rates various and malignancies were determined...
Serotype-specific surveillance for invasive pneumococcal disease (IPD) is essential assessing the impact of 10- and 13-valent conjugate vaccines (PCV10/13). The Pneumococcal Serotype Replacement Distribution Estimation (PSERENADE) project aimed to evaluate global evidence estimate PCV10/13 by age, product, schedule, syndrome. Here we systematically characterize summarize landscape routine serotype-specific IPD in PCV10/13-using countries describe subset that are included PSERENADE. Of 138...
We describe the impact of non-pharmaceutical interventions (NPIs) during COVID-19 pandemic on invasive pneumococcal disease (IPD) in Calgary. IPD declined significantly worldwide 2020 and 2021. This may be due to reduced transmission decrease circulating viruses that often co-infect with opportunistic pneumococcus. Pneumococcus has not been shown frequently or cause secondary infection SARS-CoV-2. examined compared incidence rates Calgary per quarter pre-vaccine, post-vaccine, 2021...
Importance The COVID-19 pandemic resulted in multiple socially restrictive public health measures and reported negative mental impacts youths. Few studies have evaluated incidence rates by sex, region, social determinants across an entire population. Objective To estimate the of hospitalizations for conditions, stratified determinants, children adolescents (hereinafter referred to as youths ) young adults comparing prepandemic pandemic-prevalent periods. Design, Setting, Participants This...