A5081061012- Respiratory viral infections research
- Cytomegalovirus and herpesvirus research
- Viral-associated cancers and disorders
- Polyomavirus and related diseases
- Influenza Virus Research Studies
- Parvovirus B19 Infection Studies
- Pneumonia and Respiratory Infections
- Herpesvirus Infections and Treatments
- Streptococcal Infections and Treatments
- Pneumocystis jirovecii pneumonia detection and treatment
- SARS-CoV-2 and COVID-19 Research
- Neutropenia and Cancer Infections
- Lymphoma Diagnosis and Treatment
- COVID-19 Clinical Research Studies
- Viral gastroenteritis research and epidemiology
- Antifungal resistance and susceptibility
- HIV/AIDS Research and Interventions
- Antibiotics Pharmacokinetics and Efficacy
- COVID-19 and Mental Health
- Fungal Infections and Studies
- Vaccine Coverage and Hesitancy
- Congenital Diaphragmatic Hernia Studies
- Neonatal and Maternal Infections
- Transplantation: Methods and Outcomes
- Sepsis Diagnosis and Treatment
University of Toronto
2016-2025
Hospital for Sick Children
2016-2025
SickKids Foundation
2016-2025
Institute for Clinical Evaluative Sciences
2008-2025
Research Network (United States)
2024
Children's Hospital of Eastern Ontario
1993-2022
University College London
2013-2022
Great Ormond Street Hospital
2013-2022
Western University
2021-2022
London Health Sciences Centre
2022
These updated guidelines from the American Society of Transplantation Infectious Diseases Community Practice review diagnosis, management, and prevention post-transplant lymphoproliferative disorders (PTLD) other Epstein-Barr virus (EBV) syndromes after solid organ transplantation. PTLD are a heterogeneous spectrum predominantly B-cell disorders, often extra-nodal, with complex distinct pathogeneses variable clinical presentations determined by pathologic subtype. Recent epidemiologic...
<b>Background:</b> Limited data are available on disease characteristics and outcomes of children with 2009 pandemic influenza A(H1N1) virus infection (pandemic H1N1 influenza) who have required hospital admission. <b>Methods:</b> We reviewed the charts 58 admitted to a large pediatric in Ontario, Canada, between May 8 July 22, 2009. compared risk factors, severity indicators these those 200 seasonal A during previous 5 years (2004/05 2008/09). <b>Results:</b> Children were significantly...
Background: Infants born at 33 through 35 completed weeks of gestation (33-35GA) are risk for severe respiratory syncytial virus (RSV) infection, and palivizumab prophylaxis lowers hospitalizations RSV infection by as much 80%. The 33-35GA cohort comprises 3-5% annual births; thus expert panels recommend limiting to situations in which frequency or health care impact is high. This study sought identify independent factors hospitalization infection. Methods: was a multicenter, prospective,...
Posttransplant lymphoproliferative disorder (PTLD) is recognized as potentially one of the most devastating complications organ transplantation. Epstein-Barr virus (EBV) associated with majority PTLD cases. The entity referred to EBV-associated encompasses a wide spectrum clinical conditions characterized by lymphoproliferation after These syndromes range from uncomplicated infectious mononucleosis true malignancies (1–3). Disease may be nodal or extranodal, localized, often in allograft,...
During a 4-year period 4684 nosocomial infections occurred in university pediatric hospital which admitted 78,120 patients (nosocomial infection rate (NIR) = 6.0). NIR varied from 0.17 to 14.0 on different wards or services; the highest rates (greater than equal 5.6) were found Neonatal Intensive Care Unit, infant neurosurgery, hematology/oncology, neonatal surgery, cardiology/cardiovascular Pediatric Unit and infant/toddler medicine areas. Infections most common less 23 months (NIR 11.5),...
These recommendations provide a data-supported approach to establishing guidelines. They are based on the following: (1) formal review and analysis of recently published world literature topic (via PubMed/MEDLINE search from 1996 July 2011 limited English language, human studies, children 0-18 years old); (2) A Manual for Assessing Health Practices Designing Practice Guidelines American College Physicians1; (3) guideline policies, including Association Study Liver Diseases policy development...
Novel influenza A/H1N1 virus has caused significant illness worldwide. In response to this global crisis, the American Society of Transplantation (AST) Infectious Diseases Community Practice and Transplant section The (TTS) developed a guidance document for novel H1N1. paper, we discuss current H1N1 as it relates solid organ transplantation. We include discussion around clinical presentation, diagnosis, therapy prevention specifically addressing areas such chemoprophylaxis, immunization...
Routine use of pulse oximetry has been associated with changes in bronchiolitis management and may have lowered the hospitalization threshold for patients bronchiolitis.To examine if infants whose displayed measurements artificially elevated 3 percentage points above true values experience rates at least 15% lower compared displayed.Randomized, double-blind, parallel-group trial conducted from 2008 to 2013 a tertiary-care pediatric emergency department Toronto, Ontario, Canada. Participants...
Abstract Growing evidence suggests receipt of live‐attenuated viral vaccines after solid organ transplant (SOT) has occurred and is safe needed due to lapses in herd immunity. A 2‐day consortium experts infectious diseases, transplantation, vaccinology, immunology was held with the objective review create expert recommendations for clinicians when considering live post‐SOT. For consideration VV MMR post‐transplant, exists only kidney liver recipients. vaccine post‐SOT, consider vaccination...
A randomised double blind trial was conducted to determine the efficacy of inhaled bronchodilators, salbutamol and ipratropium bromide, compared with placebo in treatment bronchiolitis. Patients, who were 2 months years age without underlying cardiac or pulmonary disease, received drug 1 (salbutamol saline placebo) followed one hour later by (ipratropium bromide placebo). Both agents administered every four hours. The patients allocated groups according a factorial design. similar...
Background. Lopinavir/ritonavir has demonstrated antiviral activity in the HIV-infected adult. Subjects. The objective of this study was to investigate a liquid coformulation lopinavir/ritonavir, combination with reverse transcriptase inhibitors, children. Methods. One hundred antiretroviral (ARV)-naive and ARV-experienced, nonnucleoside inhibitor-naive children between 6 months 12 years age participated Phase I/II, open label, multicenter trial. Subjects initially received either 230/57.5...
Importance The COVID-19 pandemic resulted in multiple socially restrictive public health measures and reported negative mental impacts youths. Few studies have evaluated incidence rates by sex, region, social determinants across an entire population. Objective To estimate the of hospitalizations for conditions, stratified determinants, children adolescents (hereinafter referred to as youths ) young adults comparing prepandemic pandemic-prevalent periods. Design, Setting, Participants This...
Objective. An outbreak of severe acute respiratory syndrome (SARS) occurred in the greater Toronto area between February and June 2003. We describe clinical, laboratory, epidemiologic features children who were admitted to Hospital for Sick Children, Toronto, with a presumptive diagnosis suspect or probable SARS. Methods. A prospective investigational study protocol was established management All ultimately classified as having SARS, another cause on basis their exposure, clinical radiologic...
After organ transplant, patients are at risk of posttransplant lymphoproliferative disorders (PTLD). The purpose this study was to analyze 26 pediatric cases PTLD observed our institution between 1988 and 1996, evaluate the validity Society for Hematopathology Workshop (SHPW) 1997 classification in patient population.Charts were reviewed analysis incidence, clinical course, outcome. Tissue samples classified by a pathologist according SHPW recommendations.By morphology, 20 monomorphic, 5...
Abstract: Post‐transplant Lymphoproliferative Disorder (PTLD) because of the Epstein–Barr Virus (EBV) is a major concern after pediatric transplantation. The group at greatest risk EBV‐seronegative recipients who receive EBV‐seropositive organs. Additional factors remain to be determined, including those among recipients. In this case‐control study, PTLD cases were biopsy‐proven over period 4 yr (1997–2000, inclusive). Each case was matched with 2 controls, based on type organ transplanted...
Background. Transplant recipients who are Epstein-Barr virus (EBV)-seronegative and receive organs from seropositive donors (EBV D+/R−) at increased risk for posttransplant lymphoproliferative disorder (PTLD) may benefit antiviral prophylaxis. We performed a multi-center trial assessing two different regimens their effect on EBV replication. Methods. D+/R− solid organ transplant were randomized to either ganciclovir placebo or immunoglobulin (IG) 3 months. Following this, patients unblinded...