A5101554237- Cytomegalovirus and herpesvirus research
- Antifungal resistance and susceptibility
- Mycobacterium research and diagnosis
- Fungal Infections and Studies
- Pneumocystis jirovecii pneumonia detection and treatment
- Herpesvirus Infections and Treatments
- Renal Transplantation Outcomes and Treatments
- Hematopoietic Stem Cell Transplantation
- Polyomavirus and related diseases
- Tuberculosis Research and Epidemiology
- Transplantation: Methods and Outcomes
- Parasites and Host Interactions
- HIV/AIDS drug development and treatment
- Respiratory viral infections research
- HIV/AIDS Research and Interventions
- Nail Diseases and Treatments
- Neutropenia and Cancer Infections
- Mosquito-borne diseases and control
- Toxoplasma gondii Research Studies
- Hepatitis C virus research
- COVID-19 Clinical Research Studies
- CAR-T cell therapy research
- Antibiotic Resistance in Bacteria
- Influenza Virus Research Studies
- COVID-19 and healthcare impacts
University of Miami
2015-2024
National Institute of Allergy and Infectious Diseases
2024
Mount Sinai Hospital
2024
Icahn School of Medicine at Mount Sinai
2024
National Institutes of Health
2024
Johns Hopkins University
2024
University of Mary
2024
Miami Transplant Institute
2019-2022
Office of Infectious Diseases
2007-2020
Sylvester Comprehensive Cancer Center
2018-2020
Host iron availability is fundamental to mucormycosis pathogenesis. The combination of liposomal amphotericin B (LAmB) and deferasirox chelation therapy synergistically improved survival in diabetic mice with mucormycosis. To determine the safety plus LAmB for mucormycosis, a multicentred, placebo-controlled, double-blinded clinical trial was conducted. Twenty patients proven or probable were randomized receive treatment (20 mg/kg/day 14 days) placebo (NCT00419770, clinicaltrials.gov)....
Background. Cytomegalovirus (CMV) disease remains an important problem in solid-organ transplant recipients, with the greatest risk among donor CMV-seropositive, recipient-seronegative (D+/R−) patients. CMV-specific cell-mediated immunity may be able to predict which patients will develop CMV disease.
Background. To improve our understanding of risk factors, management, diagnosis, and outcomes associated with histoplasmosis after solid organ transplant (SOT), we report a large series occurring SOT. Methods. All cases in SOT recipients diagnosed between 1 January 2003 31 December 2010 at 24 institutions were identified. Demographic, clinical, laboratory data collected. Results. One hundred fifty-two identified: kidney (51%), liver (16%), kidney/pancreas (14%), heart (9%), lung (5%),...
Varicella-zoster virus (VZV) infections increasingly are reported in patients with multiple sclerosis (MS) and constitute an area of significant concern, especially the advent more disease-modifying treatments MS that affect T-cell-mediated immunity. To assess incidence, risk factors, clinical characteristics VZV fingolimod-treated provide recommendations for prevention management. Rates fingolimod trials based on pooled data from completed controlled phases 2 3 studies (3916 participants)...
Cryptococcosis is a life-threatening infection among patients with human immunodeficientcy virus (HIV) infection. Therapeutic options for the treatment of central nervous system cryptococcosis are limited, especially in resource-limited settings.We conducted randomized, open-label, phase II trial Thailand and United States that compared safety efficacy intravenous amphotericin B deoxycholate (AmB) 0.7 mg/kg (the standard therapy) AmB plus fluconazole 400 mg low-dosage combination) or 800...
Novel influenza A/H1N1 virus has caused significant illness worldwide. In response to this global crisis, the American Society of Transplantation (AST) Infectious Diseases Community Practice and Transplant section The (TTS) developed a guidance document for novel H1N1. paper, we discuss current H1N1 as it relates solid organ transplantation. We include discussion around clinical presentation, diagnosis, therapy prevention specifically addressing areas such chemoprophylaxis, immunization...
Mycobacterium tuberculosis is a ubiquitous organism that infects one-third of the world’s population. In previous decades, access to organ transplantation was restricted academic medical centers in more developed, low (TB) incidence countries. Globalization, changing immigration patterns, and expansion sophisticated procedures medium high TB countries have made an increasingly important posttransplant infectious disease. Tuberculosis now one most common bacterial causes solid-organ...
Optimal clinical care and investigation of patients with mucormycosis are limited by absence controlled trials, well-defined predictors mortality or response. The Deferasirox-AmBisome Therapy for (DEFEAT Mucor) study was the first randomized trial conducted on mucormycosis, demonstrated that adjunctive deferasirox therapy did not improve outcomes disease. current describes factors from 20 enrolled to identify those associated 90-day 11 (55%) who died day 90. Age, diabetes mellitus,...
The Organ Procurement Transplant Network Disease Transmission Advisory Committee (DTAC), a multidisciplinary committee, evaluates potential donor-derived transmission events (PDDTE), including infections and malignancies, to assess for donor transmitted events.Reports of unexpected PDDTE in 2013 were fully reviewed by DTAC. A standardized algorithm was used each from given classify individual recipient that donor.Of 443 total submitted, 159 triaged not sent out the full Of 284 evaluated...
These updated guidelines from the Infectious Diseases Community of Practice American Society Transplantation review diagnosis, prevention, and management tissue blood protozoal infections in pre- post-transplant period. Significant new developments field have made it necessary to divide previous single guideline published 2013 into two sections, with intestinal parasites separated this devoted protozoa. The current update reflects increased focus on donor screening risk-based recipient...
Abstract These updated guidelines from the Infectious Diseases Community of Practice American Society Transplantation review diagnosis, prevention, and management intestinal parasites in pre‐ post‐transplant period. Intestinal are prevalent developing regions world. With increasing travel to endemic regions, changing immigration patterns, expansion transplant medicine countries, they increasingly recognized as a source morbidity mortality solid‐organ recipients. Parasitic infections may be...
Abstract Background Antimicrobial resistance (AMR) is undermining modern medicine, a problem compounded by bacterial adaptation to antibiotic pressures. Phages are viruses that infect bacteria. Their diversity and evolvability offer the prospect of their use as therapeutic solution. Reported outcomes customized phage therapy for patients with difficult-to-treat antimicrobial resistant infections. Methods We retrospectively assessed 12 cases from production center. were screened, purified,...
BackgroundKidney transplantation from donors with human immunodeficiency virus (HIV) to recipients HIV is an emerging practice. It has been performed since 2016 under the U.S. congressional Organ Policy Equity Act and currently approved for research only. The Department of Health Human Services considering expanding procedure clinical practice, but data are limited small case series that did not include without as controls.MethodsIn observational study conducted at 26 centers, we compared...
Risk factors including how changes in immunosuppression influence the occurrence of immune reconstitution syndrome (IRS) solid organ transplant (SOT) recipients with cryptococcosis have not been fully defined.SOT were identified and followed for 12 months. IRS was defined based on previously proposed criteria.Of 89 SOT recipients, 13 (14%) developed IRS. Central nervous system (CNS) disease (adjusted odds ratio [AOR], 6.23; P = .03) discontinuation calcineurin inhibitor (AOR, 5.11; .02)...
Abstract Background Letermovir was approved in 2017 for prevention of cytomegalovirus (CMV) infection seropositive (R+) allogeneic hematopoietic cell transplantation (HCT) patients. Post‐marketing data with this new agent are scarce. Methods We compared the incidence both CMV reactivation (any viremia) and clinically significant (CS‐CMVi; DNAemia leading to preemptive treatment or presence tissue invasive disease) at days +100 +200 post‐HCT 25 adult HCT patients who received letermovir...
<ns4:p><ns4:bold>Background:</ns4:bold> Cell-free DNA (cfDNA) sequencing has emerged as an effective laboratory method for rapid and noninvasive diagnosis in prenatal screening testing, organ transplant rejection screening, oncology liquid biopsies but clinical experience use of this technology diagnostic evaluation infections immunocompromised hosts is limited. </ns4:p><ns4:p> <ns4:bold>Methods:</ns4:bold> We conducted exploratory study using next-generation (NGS) detection microbial cfDNA...
Background.Cryptococcosis occurring _30 days after transplantation is an unusual event, and its characteristics are not known. Methods.Patients included 175 solid-organ transplant (SOT) recipients with cryptococcosis in a multicenter cohort. Very early-onset late-onset were define as disease or 130 transplantation, respectively. Results.Very developed 9 (5%) of the patients at mean 5.7 transplantation. Overall, 55.6% (5 9) very versus 25.9% (43 166) liver (Pp.05). early cases more likely to...