A5035024370- Global Maternal and Child Health
- Neonatal Respiratory Health Research
- Pregnancy and preeclampsia studies
- Pelvic floor disorders treatments
- Infant Development and Preterm Care
- Traumatic Brain Injury Research
- Child Nutrition and Water Access
- Cardiac Arrest and Resuscitation
- Anorectal Disease Treatments and Outcomes
- Cardiovascular Issues in Pregnancy
- Urinary Bladder and Prostate Research
- Traumatic Brain Injury and Neurovascular Disturbances
- Urinary Tract Infections Management
- Maternal and fetal healthcare
- Preterm Birth and Chorioamnionitis
- Fungal Infections and Studies
- Birth, Development, and Health
- Antifungal resistance and susceptibility
- Maternal and Perinatal Health Interventions
- Trauma and Emergency Care Studies
- HIV Research and Treatment
- Infant Nutrition and Health
- Maternal and Neonatal Healthcare
- Retinopathy of Prematurity Studies
- Pelvic and Acetabular Injuries
RTI International
2016-2025
Wildlife Conservation Society Congo
2024
Research Network (United States)
2018-2024
Duke University
2018-2023
Eunice Kennedy Shriver National Institute of Child Health and Human Development
2013-2023
Clinical Research Institute
2023
Jawaharlal Nehru Medical College
2023
Aga Khan University
2020-2023
Datta Meghe Institute of Medical Sciences
2023
Indiana University – Purdue University Indianapolis
2020-2023
<h3>Importance</h3> Women with refractory urgency urinary incontinence are treated sacral neuromodulation and onabotulinumtoxinA limited comparative information. <h3>Objective</h3> To assess whether is superior to in controlling episodes of incontinence. <h3>Design, Setting, Participants</h3> Multicenter open-label randomized trial (February 2012-January 2015) at 9 US medical centers involving 381 women <h3>Interventions</h3> Cystoscopic intradetrusor injection 200 U (n = 192) or 189)....
Anticholinergic medications and onabotulinumtoxinA are used to treat urgency urinary incontinence, but data directly comparing the two types of therapy needed.
Cryptococcosis is a life-threatening infection among patients with human immunodeficientcy virus (HIV) infection. Therapeutic options for the treatment of central nervous system cryptococcosis are limited, especially in resource-limited settings.We conducted randomized, open-label, phase II trial Thailand and United States that compared safety efficacy intravenous amphotericin B deoxycholate (AmB) 0.7 mg/kg (the standard therapy) AmB plus fluconazole 400 mg low-dosage combination) or 800...
<h3>Objective</h3> To measure exosomal and plasma levels of candidate blood biomarkers in veterans with history mild traumatic brain injury (mTBI) test their relationship chronic symptoms. <h3>Methods</h3> Exosomal neurofilament light (NfL) chain, tumor necrosis factor (TNF)–α, interleukin (IL)–6, IL-10, vascular endothelial growth (VEGF) were measured using an ultrasensitive assay a cohort 195 veterans, enrolled the Chronic Effects Neurotrauma Consortium Longitudinal Study. We examined...
Preterm birth continues to be a major public health problem contributing 75% of the neonatal mortality worldwide. Low weight (LBW) is an important but imperfect surrogate for prematurity when accurate assessment gestational age not possible. While there overlap between preterm and LBW newborns, those that are both premature at highest risk adverse outcomes. Understanding epidemiology prevention improved care in many countries, data sparse incomplete.We conducted analyses using Global...
Among extremely preterm infants, we evaluated whether bevacizumab therapy compared with surgery for retinopathy of prematurity (ROP) is associated adverse outcomes in early childhood.
Objective: The objective of the study is to measure plasma and exosomal levels tau, phosphorylated tau (p-tau), amyloid beta (Aβ) in Veterans with historical mild traumatic brain injury (mTBI) chronic neuropsychological symptoms.Methods: Tau, p-tau, Aβ40, Aβ42 were measured by ultrasensitive immunoassay exosomes from 195 enrolled Chronic Effects Neurotrauma Consortium Multicenter Observational Study. Protein biomarkers compared among groups without mTBI loss consciousness (LOC) or...
Abstract Background Pakistan has among the poorest pregnancy outcomes worldwide, significantly worse than many other low-resource countries. The reasons for these differences are not clear. In this study, we compared in to countries and explored factors that might help explain differences. Methods Global Network (GN) Maternal Newborn Health Registry (MNHR) is a prospective, population-based observational study includes all pregnant women their defined geographic communities six low-middle...
Maternal mortality is a public health problem that disproportionately affects low and lower-middle income countries (LMICs). Appropriate data sources are lacking to effectively track maternal monitor changes in this indicator over time.
The use of azithromycin reduces maternal infection in women during unplanned cesarean delivery, but its effect on those with planned vaginal delivery is unknown. Data are needed whether an intrapartum oral dose would reduce and offspring sepsis or death.
A prospective multicenter study of cryptococcal immune reconstitution inflammatory syndrome (IRIS) was conducted as a substudy the Bacteriology and Mycology Study Group 3-01. Of 101 AIDS patients with meningitis who received highly active antiretroviral therapy (HAART), 13 experienced IRIS. No association between timing HAART initiation diagnosis IRIS identified. Increased baseline serum antigen (CrAg) titer risk factor for
Different HIV-1 antigen specificities appear in sequence after transmission and the immunoglobulin G (IgG) subclass responses to HIV antigens are distinct from each other. The initial predominant IgG response infection consists of IgG1 IgG3 antibodies with a noted decline some during acute infection. Thus, we postulate that multiple antigen-specific may serve as surrogates for relative time since acquisition.We determined magnitude, peak, half-life 41 HIV-1-infected individuals followed...
Primary objectives: To establish and comprehensively evaluate a large cohort of US veterans who served in recent military conflicts order to better understand possible chronic late-life effects mild traumatic brain injury (mTBI), including those that may stem from neurodegeneration.Research design: Cross-sectional prospective longitudinal.Methods procedures: Inclusion criteria are prior combat exposure deployment(s) Operation Enduring Freedom, Iraqi Freedom or one their follow-on...
In Brief OBJECTIVE: To construct and validate a prediction model for estimating the risk of de novo stress urinary incontinence (SUI) after vaginal pelvic organ prolapse (POP) surgery compare it with predictions using preoperative testing expert surgeons' predictions. MATERIALS AND METHODS: Using data set (n=457) from Outcomes Following Vaginal Prolapse Repair Midurethral Sling trial, 12 clinical predictors SUI was constructed. De determined by Pelvic Floor Distress Inventory responses...
Prevention of HIV-1 transmission at mucosal surfaces will likely require durable pre-existing anti-HIV-1 antibodies (Abs). Defining the ontogeny, specificities and potentially protective nature initial virus-specific B-cell response be critical for understanding how to induce Ab responses by vaccination. Genital fluids from patients within earliest stages acute infection (Fiebig I-VI) were examined multiple anti-HIV specificities. Gp41 (but not gp120) Env immunoglobulin (Ig)A Abs frequently...
Abstract Background To determine the gender differences in neonatal mortality, stillbirths, and perinatal mortality south Asia using Global Network data from Maternal Newborn Health Registry. Methods This study is a secondary analysis of prospectively collected three Asian sites Network. The maternal demographic, clinical characteristics, rates early (1–7 days), late (8–28 between 29–42 days number infants hospitalized after birth were compared male female infants. Results Between 2010 2018,...
Due to high fertility rates in some low and lower-middle income countries, the interval between pregnancies can be short, which may lead adverse maternal neonatal outcomes.We analyzed data from women enrolled NICHD Global Network Maternal Newborn Health Registry (MNHR) 2013 through 2018. We report characteristics outcomes relationship inter-delivery (IDI, time previous delivery [live or stillborn] of index birth), by category 6-17 months (short), 18-36 (reference), 37-60 months, 61-180...
To assess, on a population basis, the medical care for pregnant women in specific geographic regions of six countries before and during first year coronavirus disease 2019 (COVID-19) pandemic relationship to pregnancy outcomes.Prospective, population-based study.Communities Kenya, Zambia, Democratic Republic Congo, Pakistan, India Guatemala.Pregnant enrolled Global Network Women's Children's Health's Maternal Newborn Health Registry.Pregnancy/delivery services outcomes pre-COVID-19...
ABSTRACT Genes influencing opioid use disorder (OUD) biology have been identified via genome-wide association studies (GWAS), gene expression, and network analyses. These discoveries provide opportunities to identifying existing compounds targeting these genes for drug repurposing studies. However, systematically integrating discovery results relevant available pharmacotherapies OUD is challenging. To address this, we’ve constructed a framework that leverages databases identify candidate...
To evaluate the impact of heart rate-guided basic resuscitation compared to Helping Babies Breathe on neonatal outcomes and practices in Democratic Republic Congo. We conducted a pre-post clinical trial comparing three facilities, enrolling in-born neonates ≥28 weeks gestation. collected observational data during convenience sample resuscitations extracted from medical record for all participants. evaluated our primary outcome effective breathing at minutes after birth among newborns not...