A5031814931- Global Maternal and Child Health
- Pregnancy and preeclampsia studies
- Child Nutrition and Water Access
- Infant Development and Preterm Care
- Neonatal Respiratory Health Research
- Birth, Development, and Health
- Prenatal Screening and Diagnostics
- Maternal and fetal healthcare
- Autopsy Techniques and Outcomes
- Gestational Diabetes Research and Management
- Grief, Bereavement, and Mental Health
- Fetal and Pediatric Neurological Disorders
- Maternal and Perinatal Health Interventions
- Child Nutrition and Feeding Issues
- Child and Adolescent Health
- Emergency and Acute Care Studies
- Migration, Health and Trauma
- Neonatal and fetal brain pathology
- Cardiovascular Issues in Pregnancy
- COVID-19 Impact on Reproduction
- Preterm Birth and Chorioamnionitis
- Maternal Mental Health During Pregnancy and Postpartum
- Palliative Care and End-of-Life Issues
- Neuroscience of respiration and sleep
- Genomic variations and chromosomal abnormalities
RTI International
2015-2024
Eunice Kennedy Shriver National Institute of Child Health and Human Development
2013-2024
National Heart Lung and Blood Institute
2024
Columbia University Irving Medical Center
2013-2023
Intermountain Healthcare
2013-2021
University of Utah
2013-2021
Emory University
2013-2021
National Institutes of Health
2013-2021
The University of Texas Medical Branch at Galveston
2013-2021
Brown University
2013-2021
In Brief OBJECTIVE: To compare illicit drug and smoking use in pregnancies with without stillbirth. METHODS: The Stillbirth Collaborative Research Network conducted a case–control study from March 2006 to September 2008, covering more than 90% of deliveries residents five priori–defined geographically diverse regions. attempted include all stillbirths representative liveborn controls. Umbilical cord samples cases controls were collected frozen for subsequent batch analysis. Maternal serum...
Genetic abnormalities have been associated with 6 to 13% of stillbirths, but the true prevalence may be higher. Unlike karyotype analysis, microarray analysis does not require live cells, and it detects small deletions duplications called copy-number variants. The Stillbirth Collaborative Research Network conducted a population-based study stillbirth in five geographic catchment areas. Standardized postmortem examinations analyses were performed. A single-nucleotide polymorphism array was...
Because large, prospective, population-based data sets describing maternal outcomes are typically not available in low- and middle-income countries, it is difficult to monitor mortality rates over time identify factors associated with mortality. Early identification of risk essential develop comprehensive intervention strategies preventing pregnancy-related complications. Our objective was describe a multi-country dataset determine maternal, pregnancy-related, delivery postpartum...
In Brief OBJECTIVE: To compare placental lesions for stillbirth cases and live birth controls in a population-based study. METHODS: Pathologic examinations were performed on placentas from singleton pregnancies using standard protocol. Data analyzed overall within gestational age groups at delivery. RESULTS: Placentas 518 stillbirths 1,200 births studied. Single umbilical artery was present 7.7% of 1.7% births, velamentous cord insertion 5% 1.1% diffuse terminal villous immaturity 10.3% 2.3%...
OBJECTIVE: To estimate the usefulness of each diagnostic test in work-up for potential causes stillbirth. METHODS: A secondary analysis 512 stillbirths enrolled Stillbirth Collaborative Research Network from 2006 to 2008 was performed. The a multisite, geographically, racially, and ethnically diverse, population-based study stillbirth United States. Participants underwent standardized evaluations that included maternal interview, medical record abstraction, biospecimen collection, fetal...
Reported benefits of maternal nutrition supplements commenced during pregnancy in low-resource populations have typically been quite limited.This study tested the effects on newborn size, especially length, commencing for women ≥3 mo before conception (Arm 1), compared with same supplement late first trimester 2) or not at all (control Arm 3).Women First was a 3-arm individualized randomized controlled trial (RCT). The intervention lipid-based micronutrient supplement; protein-energy also...
In the majority of cases, cause stillbirth remains unknown despite detailed clinical and laboratory evaluation. Approximately 10 to 20% stillbirths are attributed chromosomal abnormalities. However, causal nature single-nucleotide variants small insertions deletions in exomes has been understudied.
Preterm birth continues to be a major public health problem contributing 75% of the neonatal mortality worldwide. Low weight (LBW) is an important but imperfect surrogate for prematurity when accurate assessment gestational age not possible. While there overlap between preterm and LBW newborns, those that are both premature at highest risk adverse outcomes. Understanding epidemiology prevention improved care in many countries, data sparse incomplete.We conducted analyses using Global...
Maternal mortality is a public health problem that disproportionately affects low and lower-middle income countries (LMICs). Appropriate data sources are lacking to effectively track maternal monitor changes in this indicator over time.
Summary Parker CB, Hogue CJR, Koch MA, Willinger M, Reddy UM, Thorsten VR, Dudley DJ, Silver RM, Coustan D, Saade GR, Conway Varner MW, Stoll B, Pinar H, Bukowski R, Carpenter Goldenberg R for the Stillbirth Collaborative Research Network. Network: design, methods and recruitment experience. Paediatric Perinatal Epidemiology 2011; 25: 425–435. The Network (SCRN) has conducted a multisite, population‐based, case–control study, with prospective enrolment of stillbirths livebirths at time...
Umbilical cord abnormalities are commonly cited as a cause of stillbirth, but details regarding these stillbirths rare. Our objective was to characterize associated with umbilical using rigorous criteria and examine risk factors.The Stillbirth Collaborative Research Network conducted case-control study stillbirth live births from 2006 2008. We analyzed that underwent complete fetal placental evaluations death analysis the INCODE (Initial Causes Fetal Death) classification system. abnormality...
OBJECTIVE: To better characterize infection-related stillbirth in terms of pathogenesis and microbiology. METHODS: We conducted a secondary analysis 512 stillbirths prospective, multisite, geographically, racially ethnically diverse, population-based study the United States. Cases underwent evaluation that included maternal interview, chart abstraction, biospecimen collection, fetal autopsy, placental pathology. Recommended evaluations syphilis parvovirus serology. Each case was assigned...
We sought to determine the knowledge, attitudes and practices of pregnant women regarding COVID-19 vaccination in pregnancy seven low- middle-income countries (LMIC).
The Stillbirth Collaborative Research Network (SCRN) was organized to study the scope and causes of stillbirth (SB) in United States. objective this report is describe approach used for placental examination performed as part study. SCRN consists a multidisciplinary team investigators from five clinical sites, National Institute Child Health Human Development, Data Coordination Analysis Center. population-based cohort nested case-control study, with prospective enrollment women SB live...
OBJECTIVE: To investigate whether early developmental intervention (EDI) can positively affect the trajectories of cognitive development among children from low-resource families. METHODS: Longitudinal analyses were conducted data 293 in Brain Research to Ameliorate Impaired Neurodevelopment Home-based Intervention Trial, a randomized controlled trial home-based EDI program, examine Bayley Scales Infant Development—Second Edition Mental Development Index (MDI) scores 12 36 months age young...
To assess, on a population basis, the medical care for pregnant women in specific geographic regions of six countries before and during first year coronavirus disease 2019 (COVID-19) pandemic relationship to pregnancy outcomes.Prospective, population-based study.Communities Kenya, Zambia, Democratic Republic Congo, Pakistan, India Guatemala.Pregnant enrolled Global Network Women's Children's Health's Maternal Newborn Health Registry.Pregnancy/delivery services outcomes pre-COVID-19...
After reviewing the state of knowledge about scope and causes stillbirth (SB) in a special workshop sponsored by Eunice Kennedy Shriver National Institute Child Health Human Development (NICHD), participants determined that there is little guidance regarding best use postmortem examination (PM) to address pathogenesis stillbirth. In this report, we describe PM procedure designed used NICHD-supported Stillbirth Cooperative Research Network (SCRN). Perinatal pathologists, clinicians,...
To estimate the proportion of potentially preventable stillbirths in United States.
South Asia has >50% of the global burden low birth weight (LBW). The objective was to determine extent which maternal nutrition interventions commenced before conception or in 1st trimester improved fetal growth this region. This a secondary analysis combined newborn anthropometric data for Asian sites (India and Pakistan) Women First Preconception Maternal Nutrition Trial. Participants were 972 mothers who poor, rural, unselected on basis nutritional status, had been randomized receive...
This randomized controlled trial aims to evaluate the effects of an early developmental intervention program on development young children in low- and low-middle-income countries who are at risk for neurodevelopmental disability because birth asphyxia. A group without perinatal complications evaluated same protocol compare healthy infants communities. Birth asphyxia is leading specific cause neonatal mortality also main long-term morbidity including mental retardation, cerebral palsy, other...