A5047219576- Prenatal Screening and Diagnostics
- Assisted Reproductive Technology and Twin Pregnancy
- Pregnancy and preeclampsia studies
- Jury Decision Making Processes
- Legal Systems and Judicial Processes
- Law, Economics, and Judicial Systems
- Glioma Diagnosis and Treatment
- Fetal and Pediatric Neurological Disorders
- Congenital Anomalies and Fetal Surgery
- Brain Metastases and Treatment
- Parvovirus B19 Infection Studies
- Criminal Justice and Corrections Analysis
- Law, Rights, and Freedoms
- Deception detection and forensic psychology
- Criminal Law and Evidence
- Renal and related cancers
- Food Safety and Hygiene
- Maternal and fetal healthcare
- Blood groups and transfusion
- Language, Discourse, Communication Strategies
- Genetic Syndromes and Imprinting
- Decision-Making and Behavioral Economics
- Genomic variations and chromosomal abnormalities
- Platelet Disorders and Treatments
- Maternal and Perinatal Health Interventions
Beth Israel Deaconess Medical Center
2017-2025
The University of Texas MD Anderson Cancer Center
2019-2025
Harvard University
2018-2024
Boston Children's Hospital
2024
Lemuel Shattuck Hospital
2023
Baptist Memorial Hospital
2023
Michigan State University
2010-2022
Westat (United States)
2013-2021
Children's Hospital of Philadelphia
2020
Johns Hopkins University
2019
<h3>Background</h3> This paper describes the methods and conceptual framework for Wave 1 of Population Assessment Tobacco Health (PATH) Study data collection. The National Institutes Health, through Institute on Drug Abuse, is partnering with Food Administration9s (FDA) Center Products to conduct PATH under a contract Westat. <h3>Methods</h3> nationally representative, longitudinal cohort study 45 971 adults youth in USA, aged 12 years older. was conducted from September 2013 15 December...
Genetic abnormalities have been associated with 6 to 13% of stillbirths, but the true prevalence may be higher. Unlike karyotype analysis, microarray analysis does not require live cells, and it detects small deletions duplications called copy-number variants. The Stillbirth Collaborative Research Network conducted a population-based study stillbirth in five geographic catchment areas. Standardized postmortem examinations analyses were performed. A single-nucleotide polymorphism array was...
Black people are 13.6% of the American population but 53% 3,200 exonerations listed in National Registry Exonerations as August, 2022. Judging from exonerations, innocent Americans seven times more likely than white to be falsely convicted serious crimes. We see this racial disparity, varying degrees, for all major crime categories except collar crime. This report examines disparities three types that produce largest numbers exonerations: murder, sexual assault, and drug crimes.For both...
The rate of erroneous conviction innocent criminal defendants is often described as not merely unknown but unknowable. There no systematic method to determine the accuracy a conviction; if there were, these errors would occur in first place. As result, very few false convictions are ever discovered, and those that discovered representative group whole. In United States, however, high proportion do come light produce exonerations concentrated among tiny minority cases which sentenced death....
Aim: To ascertain the maximum tolerated dose (MTD)/maximum feasible (MFD) of WP1066 and p-STAT3 target engagement within recurrent glioblastoma (GBM) patients. Patients & methods: In a first-in-human open-label, single-center, single-arm 3 + design Phase I clinical trial, eight patients were treated with until disease progression or unacceptable toxicities. Results: absence significant toxicity, MFD was identified to be 8 mg/kg. The most common adverse event grade 1 nausea diarrhea in 50% No...
In Brief Because they share a common placenta, monochorionic gestations are subject to unique pregnancy complications that can threaten the life and health of both fetuses therefore impose disproportionate disease burden on overall perinatal morbidity mortality. Early detection these processes may allow for prompt referral regional treatment center, comprehensive counseling, better patient outcomes. The North American Fetal Therapy Network is consortium 30 medical institutions in United...
In Brief The identification of circulating cell-free fetal DNA in maternal plasma has led to the introduction noninvasive prenatal tests with high sensitivity and specificity for common aneuploidies (trisomy 13, trisomy 18, 21). A new expanded testing panel that includes five microdeletion syndromes (22q11 deletion syndrome, cri-du-chat [5p minus], Prader Willi or Angelman 1p36 syndrome) two usually associated nonviable pregnancies 16 22) is now available. This will be performed unless an...
In Brief Owing to vascular connections within a single placenta, monochorionic gestations present distinctive prenatal management challenges. Complications that can arise as result of unbalanced hemodynamic exchange (twin–twin transfusion syndrome and twin anemia polycythemia sequence) unequal placental sharing (selective fetal growth restriction) should be kept in mind while is being planned. Because unique angioarchitecture, what happens one directly affect the other. Death death or...
In the first part of this article, we address problems inherent in studying wrongful convictions: our pervasive ignorance and extreme difficulty obtaining data that need to answer even basic questions. The main reason know so little about false convictions is that, by definition, they are hidden from view. As a result, it nearly impossible gather reliable on characteristics or frequency convictions. addition, have very limited criminal investigations prosecutions general, if could somehow...
Abstract Objective Delineate prenatal features of Costello syndrome (caused by HRAS mutations), which consists mental retardation, facial, cardiovascular, skin, and musculoskeletal anomalies, tumor predisposition. Methods Literature new cases classified as Group I (pre‐ ), II ( confirmed), III confirmed in natural history study, plus three contributed cases). Results Polyhydramnios occurred most (mean 79%) pregnancies Groups (98), (107), (17); advanced paternal age prematurity were noted...
ABSTRACT Objectives The aim of our study was to describe outcomes fetuses with cystic hygromas (CH) based on results non‐invasive prenatal testing (NIPT), nuchal translucency (NT) size, and spontaneous hygroma regression. Methods This a retrospective cohort all patients CH diagnosed first trimester ultrasound at institution over 9‐year period. primary were pathogenic genetic abnormalities, structural malformations perinatal loss. Secondary included pregnancy termination, live birth,...
To assess the clinical utility of cell-free DNA (cfDNA)-based screening for aneuploidies offered through primary obstetrical care providers to a general pregnancy population. Patient educational materials were developed and validated trained. Serum was collected reflexive testing cfDNA failures. Providers patients surveyed concerning knowledge, decision making, satisfaction. Pregnancy outcome determined by active or passive ascertainment. Between September 2014 July 2015, 72 screened 2,691...
<b><i>Introduction:</i></b> To describe the incidence and risk factors for iatrogenic premature preterm rupture of membranes (iPPROM) after fetoscopic laser surgery twin-to-twin-transfusion syndrome. <b><i>Materials Methods:</i></b> This is a retrospective review all patients who have undergone at single fetal treatment center since 2000. We defined iPPROM as spontaneous before onset labor prior to 34 weeks gestation. The cohort was compared...