A5057214759- Glioma Diagnosis and Treatment
- Cerebrospinal fluid and hydrocephalus
- Fetal and Pediatric Neurological Disorders
- Neuroblastoma Research and Treatments
- Spinal Dysraphism and Malformations
- Vascular Malformations Diagnosis and Treatment
- Traumatic Brain Injury and Neurovascular Disturbances
- Radiopharmaceutical Chemistry and Applications
- Neurosurgical Procedures and Complications
- Meningioma and schwannoma management
- Surgical Simulation and Training
- Cancer Genomics and Diagnostics
- Cancer, Hypoxia, and Metabolism
- Advanced Electron Microscopy Techniques and Applications
- Parkinson's Disease Mechanisms and Treatments
- Microtubule and mitosis dynamics
- Neuroscience and Neuropharmacology Research
- Orthopedic Infections and Treatments
- Single-cell and spatial transcriptomics
- Spine and Intervertebral Disc Pathology
- Chemical Reactions and Isotopes
- Pituitary Gland Disorders and Treatments
- Artificial Intelligence in Healthcare and Education
- History of Medical Practice
- Cardiac Arrest and Resuscitation
Northwestern University
2021-2025
Neurological Surgery
2021-2024
Lurie Children's Hospital
2021-2024
Northwestern University
2024
CNS Research (United States)
2021
St. Jude Children's Research Hospital
2016-2020
University of Tennessee Health Science Center
2005-2019
Semmes Murphey Foundation
2017-2018
Oxford University Press (United Kingdom)
2018
Le Bonheur Children's Hospital
2018
OBJECT :The object of this study was to identify and quantify predictors burnout career satisfaction among US neurosurgeons.All members (3247) the American Association Neurological Surgeons (AANS) were invited participate in a survey between September December 2012. Responses evaluated through univariate analysis. Factors independently associated with determined using multivariable logistic regression. Subgroup analysis academic nonacademic neurosurgeons performed as well.The response rate...
Aim: To ascertain the maximum tolerated dose (MTD)/maximum feasible (MFD) of WP1066 and p-STAT3 target engagement within recurrent glioblastoma (GBM) patients. Patients & methods: In a first-in-human open-label, single-center, single-arm 3 + design Phase I clinical trial, eight patients were treated with until disease progression or unacceptable toxicities. Results: absence significant toxicity, MFD was identified to be 8 mg/kg. The most common adverse event grade 1 nausea diarrhea in 50% No...
Background: High grade glioma, also known as glioblastoma multiform (GBM) a highly aggressive brain tumor, requires advanced systems to study tumor-stroma interactions. Paired in vitro and vivo model such 3D organoids PDOX models derived from EGFP-SCID mice offered unique opportunity precisely rapidly differentiation of mouse (EGFP positive) human tumor cells, thereby facilitating the visualization analysis tumor/normal cell interactions vivo. Methods: received intra-cranial implantation...
Childhood neurodevelopmental disorders like Angelman syndrome and autism may be the result of underlying defects in neuronal plasticity ongoing problems with synaptic signaling. Some these due to abnormal monoamine levels different regions brain. Ube3a, a gene that causes (AS) when maternally deleted is associated duplicated has recently been shown regulate synthesis Drosophila Therefore, we examined striatum, ventral midbrain, frontal cerebral cortex, cerebellar cortex hippocampus Ube3a...
OBJECTIVE Penetrating brain injury in civilians is much less common than blunt but more severe overall. Gunshot wounds (GSWs) cause high morbidity and mortality related to penetrating injury; however, there are few reports on the management outcome of intracranial GSWs children. The goals this study were identify clinical radiological factors predictive for death children externally validate a recently proposed pediatric prognostic scale. METHODS authors conducted retrospective review...
Several members of the tetrahydroisoquinoline (TIQ) family monoamine alkaloids can be formed from dopamine or its oxidized metabolites and may involved in pathogenesis monoaminergic cell death Parkinson's disease (PD). Using enantiomeric-selective high-performance liquid chromatography with electrochemical detection tandem mass spectroscopy, regional concentrations several TIQ derivatives, including salsolinols, were determined mouse, rat, normal human, PD brain. derivatives detected all...
Image guidance is a promising technology that could lead to lower rates of premature shunt failure by decreasing the rate inaccurate proximal catheter placement.To perform detailed radiographic analysis ventricular size using 3 well-described methods and compare revision rates.Our surgery research database was queried identify procedures (new placement or revision) where frameless stereotactic electromagnetic neuronavigation used (January 2010-June 2016). A randomly selected cohort surgeries...
Septic cerebral venous sinus thrombosis (CVST) is a recognized complication of pediatric sinogenic and otogenic intracranial infections. The optimal treatment paradigm remains controversial. Proponents anticoagulation highlight its role in preventing thrombus propagation promoting recanalization, while others cite the risk hemorrhagic complications, especially after neurosurgical procedure for an epidural abscess or subdural empyema. Here, authors investigated diagnosis, management, outcomes...
Abstract Purpose: Curing all children with brain tumors will require an understanding of how each subtype responds to conventional treatments and best combine existing novel therapies. It is extremely challenging acquire this knowledge in the clinic alone, especially among patients rare tumors. Therefore, we developed a preclinical tumor platform test combinations therapies manner that closely recapitulates trials. Experimental Design: A multidisciplinary team was established design conduct...
Intracranial arachnoid cysts are a rare condition thought to be congenital in nature. Treatment of intracranial remains controversial based on their variable presentation. options include CSF shunting, endoscopic fenestration, or craniotomy and open fenestration for larger cysts. The complications these procedures can hydrocephalus, subdural hematomas, hygromas, and--more rarely--intraparenchymal hemorrhage. authors found very few reports hemorrhagic infarction as complication cyst the...
Despite being the leading cause of childhood mortality, pediatric gliomas have been relatively understudied, and repurposing immunotherapies has not successful. Whole transcriptome sequencing, single-cell sequential multiplex immunofluorescence were used to identify an immunotherapy strategy evaluated in multiple preclinical glioma models. MAPK-driven a higher interferon signature relative other molecular subgroups. Single-cell sequencing identified activated cytotoxic microglia population...