A5100711195- Glioma Diagnosis and Treatment
- Cancer Research and Treatments
- Cancer, Hypoxia, and Metabolism
- Epigenetics and DNA Methylation
- PI3K/AKT/mTOR signaling in cancer
- Melanoma and MAPK Pathways
- Neuroblastoma Research and Treatments
- Cancer Cells and Metastasis
- Cancer Genomics and Diagnostics
- Synthesis and biological activity
- Histone Deacetylase Inhibitors Research
- MicroRNA in disease regulation
- RNA modifications and cancer
- Chromatin Remodeling and Cancer
- Protein Degradation and Inhibitors
- Cytokine Signaling Pathways and Interactions
- Microtubule and mitosis dynamics
- Virus-based gene therapy research
- Nanoplatforms for cancer theranostics
- ATP Synthase and ATPases Research
- Hedgehog Signaling Pathway Studies
- Estrogen and related hormone effects
- Sarcoma Diagnosis and Treatment
- CAR-T cell therapy research
- Ubiquitin and proteasome pathways
Sun Yat-sen University
2013-2025
Shenzhen Children's Hospital
2020-2025
The Seventh Affiliated Hospital of Sun Yat-sen University
2023-2025
Second Affiliated Hospital of Nanjing Medical University
2020-2024
The University of Texas Health Science Center at San Antonio
2014-2024
Texas Children's Hospital
2014-2024
Baylor College of Medicine
2015-2024
Children's Cancer Center
2014-2024
Lurie Children's Hospital
2019-2024
Northwestern University
2018-2024
OBJECTIVE Oxidative stress induced by free fatty acids contributes to the development of cardiovascular diseases in patients with metabolic syndrome. Reducing oxidative may attenuate these pathogenic processes. Activation AMP-activated protein kinase (AMPK) has been reported reduce intracellular reactive oxygen species (ROS) levels. The thioredoxin (Trx) system is a major antioxidant system. In this study, we investigated mechanisms involved AMPK-mediated regulation Trx expression and...
Abstract Valproic acid is a well-tolerated anticonvulsant that has been identified recently as histone deacetylase inhibitor. To evaluate the antitumor efficacy and mechanisms of action valproic in medulloblastoma supratentorial primitive neuroectodermal tumor (sPNET), which are among most common malignant brain tumors children with poor prognosis, two (DAOY D283-MED) one sPNET (PFSK) cell lines were treated evaluated panel vitro vivo assays. Our results showed acid, at clinically safe...
To identify therapeutic targets for glioblastoma (GBM), we performed genome-wide CRISPR-Cas9 knockout (KO) screens in patient-derived GBM stem-like cells (GSCs) and human neural stem/progenitors (NSCs), non-neoplastic stem cell controls, genes required their vitro growth. Surprisingly, the vast majority GSC-lethal hits were found outside of molecular networks commonly altered GSCs (e.g., oncogenic drivers). In vivo validation GSC-specific revealed several strong hits, including wee1-like...
Separase is an endopeptidase that separates sister chromatids by cleaving cohesin Rad21 during the metaphase-to-anaphase transition. Conditional expression of in tetracycline-inducible diploid FSK3 mouse mammary epithelial cells with both p53 WT and mutant (Ser-233-234) alleles unknown physiological significance develops aneuploidy within 5 days induction vitro. Overexpression induces premature separation chromatids, lagging chromosomes, anaphase bridges. In vivo transplant model,...
We previously showed that primary tumor-based orthotopic xenograft mouse models of medulloblastoma replicated the histopathological phenotypes patients' original tumors. Here, we performed global gene expression profiling 11 patient-specific to further determine whether tumors were molecularly accurate during serial subtransplantations in brains and they represented all molecular subtypes recently described. Analysis transcriptomes 9 pairs matched passage I xenografts revealed high...
Abstract Recent identification of cancer stem cells in medulloblastoma (MB) and high-grade glioma has stimulated an urgent need for animal models that will not only replicate the biology these tumors, but also preserve their cell pool. We hypothesize direct injection fresh surgical specimen MB tissues into anatomically equivalent locations immune-deficient mouse brains facilitate formation clinically accurate xenograft tumors by allowing brain tumor cells, together with non-stem stromal to...
Abstract Background A Pediatric Brain Tumor Consortium (PBTC) phase I/II trial of veliparib and radiation followed by temozolomide (TMZ) was conducted in children with newly diagnosed diffuse intrinsic pontine glioma (DIPG). The objectives were to: (i) estimate the recommended II dose (RP2D) concurrent radiation; (ii) evaluate pharmacokinetic parameters during (iii) feasibility intrapatient TMZ escalation; (iv) describe toxicities protocol therapy; (v) overall survival distribution compared...
The common and frequent disease, ulcerative colitis (UC), causes serious physical mental distress to patients. M2 macrophages have proven play a role in anti-inflammation, which is new potential target for UC therapy. In this study, we designed safe macrophages-targeting oral drug delivery system. Natural products, berberine (BBR), Epigallocatechin Gallate (EGCG) with anti-inflammatory activity were assembled encapsulated into yeast microcapsule (YM), generating therapeutic system...
Cancer and diabetes are significant diseases that pose a threat to human health. Their interconnection is complex, particularly when they coexist, often necessitating multiple therapeutic approaches attain remission. Sodium-glucose cotransporter protein two inhibitors (SGLT-2i) emerged as treatment for hyperglycemia, but subsequently exhibited noteworthy extra-glycemic properties, such being registered the of heart failure chronic kidney disease, especially with co-existing albuminuria,...
Ulcerative colitis (UC), an immune-mediated chronic inflammatory disease, drastically impacts patients' quality of life and increases their risk colorectal cancer worldwide. However, effective oral targeted delivery retention drugs in colonic lesions are still great challenges the treatment UC. Coacervate microdroplets, formed by liquid-liquid phase separation, recently explored drug as simplicity fabrication, spontaneous enrichment on small molecules biological macromolecules, high loading...
Abstract Purpose: The primary purpose of this trial was to define and describe the toxicities oral valproic acid (VPA) at doses required maintain trough concentrations 100 150 mcg/mL or 200 in children with refractory solid central nervous system (CNS) tumors. Secondary objectives included assessment free total VPA pharmacokinetics (PKs) histone acetylation peripheral blood mononuclear cells (PBMC) steady state. Patients Methods: Oral VPA, initially administered twice daily subsequently...