Andrew Roth
A5066899464- Cancer Genomics and Diagnostics
- Cancer survivorship and care
- Single-cell and spatial transcriptomics
- Palliative Care and End-of-Life Issues
- Childhood Cancer Survivors' Quality of Life
- Zebrafish Biomedical Research Applications
- Cancer-related cognitive impairment studies
- Lymphoma Diagnosis and Treatment
- Family Support in Illness
- Gene expression and cancer classification
- Neuroendocrine regulation and behavior
- Genomics and Phylogenetic Studies
- Cell Image Analysis Techniques
- Cancer Immunotherapy and Biomarkers
- Cancer Treatment and Pharmacology
- Receptor Mechanisms and Signaling
- Genetic factors in colorectal cancer
- Evolution and Genetic Dynamics
- Ovarian cancer diagnosis and treatment
- Optimism, Hope, and Well-being
- Bayesian Methods and Mixture Models
- Neurotransmitter Receptor Influence on Behavior
- Sexual function and dysfunction studies
- Intensive Care Unit Cognitive Disorders
- CAR-T cell therapy research
BC Cancer Agency
2012-2024
University of British Columbia
2012-2024
Memorial Sloan Kettering Cancer Center
2014-2024
Ludwig Cancer Research
2015-2024
University of Oxford
2015-2024
Cornell University
1998-2024
Terry Fox Research Institute
2023
Spinal Cord Injury BC
2023
Northwestern University
2022
Provincial Health Services Authority
2020-2021
BACKGROUND As more oncology care is moved to the outpatient setting, need for a rapid means oncologists identify patients with significant distress has increased. Concurrent this move been pressure reduce time spent each patient, adding likelihood that distressed patient will not be recognized and remain untreated in current health environment. METHODS A pilot program was conducted prostate carcinoma clinic test feasibility of two-stage approach identifies refers them treatment. Two pencil...
We conducted two studies with medically hospitalized cancer and acquired immunodeficiency syndrome (AIDS) patients to assess the reliability validity of a new measure delirium severity, Memorial Delirium Assessment Scale (MDAS). The first study used multiple raters who jointly administered MDAS 33 patients, 17 whom met DSM III-R/DSM IV criteria for delirium, 8 diagnostic another cognitive impairment disorder (for example, dementia), had non-cognitive psychiatric disorders adjustment...
Germline truncating mutations in DICER1, an endoribonuclease the RNase III family that is essential for processing microRNAs, have been observed families with pleuropulmonary blastoma-family tumor and dysplasia syndrome. Mutation carriers are at risk nonepithelial ovarian tumors, notably sex cord-stromal tumors.We sequenced whole transcriptomes or exomes of 14 tumors noted closely clustered region DICER1 encoding IIIb domain four samples. We then this additional certain other queried effect...
High-grade serous ovarian cancer (HGSC) is characterized by poor outcome, often attributed to the emergence of treatment-resistant subclones. We sought measure degree genomic diversity within primary, untreated HGSCs examine natural state tumour evolution prior therapy. performed exome sequencing, copy number analysis, targeted amplicon deep sequencing and gene expression profiling on 31 spatially temporally separated HGSC specimens (six patients), including masses, distant metastases...
The evolution of cancer genomes within a single tumor creates mixed cell populations with divergent somatic mutational landscapes. Inference subpopulations has been disproportionately focused on the assessment point mutations, whereas computational methods targeting evolutionary dynamics copy number alterations (CNA) and loss heterozygosity (LOH) in whole-genome sequencing data remain underdeveloped. We present novel probabilistic model, TITAN, to infer CNA LOH events while accounting for...
Identifying transcript location in cells where specific RNAs occur within a cell or tissue has been limited by technology and imaging capabilities. Expansion microscopy allowed for better visualization of small structures expanding the tissues with polymer- hydrogel-based system. Alon et al. combined expansion long-read situ RNA sequencing, resulting more precise transcripts. This method, termed “ExSeq” was used to detect RNAs, both new transcripts those previously demonstrated localize...
Intussusception is the telescoping of a segment bowel into its adjacent segment. It known cause abdominal pain in pediatric population, however, it rare adult. Adults do not always present with typical symptoms seen young children, making clinical diagnosis more difficult. The etiology adult intussusception can be idiopathic, benign, or malignant. Diagnosis most accurately made computed tomography, which sensitive detecting as well potential lead points.This study presents four patients...
Loss of heterozygosity (LOH) and copy number alteration (CNA) feature prominently in the somatic genomic landscape tumors. As such, karyotypic aberrations cancer genomes have been studied extensively to discover novel oncogenes tumor-suppressor genes. Advances sequencing technology enabled cost-effective detection tumor genome transcriptome mutation events at single-base-pair resolution; however, computational methods for predicting segmental regions LOH this context are not yet fully...
Follicular lymphoma (FL) is an indolent, yet incurable B cell malignancy. A subset of patients experience increased mortality rate driven by two distinct clinical end points: histological transformation and early progression after immunochemotherapy. The nature tumor clonal dynamics leading to these points poorly understood, previously determined genetic alterations do not explain the majority transformed cases or accurately predict progressive disease. We contend that detailed knowledge...
Abstract A holistic understanding of tissue and organ structure function requires the detection molecular constituents in their original three-dimensional (3D) context. Imaging mass cytometry (IMC) enables simultaneous up to 40 antigens transcripts using metal-tagged antibodies but has so far been restricted two-dimensional imaging. Here we report development 3D IMC for multiplexed analysis at single-cell resolution demonstrate utility technology by human breast cancer samples. The resulting...
How cell-to-cell copy number alterations that underpin genomic instability
Abstract BACKGROUND The psychological difficulties facing men with prostate cancer are acknowledged widely, yet identifying who may benefit from mental health treatment has proven to be a challenging task. authors developed the Memorial Anxiety Scale for Prostate Cancer (MAX‐PC) facilitate identification and assessment of cancer‐related anxiety. This scale consists three subscales that measure general anxiety, anxiety related specific antigen (PSA) levels in particular, fear recurrence....
Abstract Motivation: Identification of somatic single nucleotide variants (SNVs) in tumour genomes is a necessary step defining the mutational landscapes cancers. Experimental designs for genome-wide ascertainment mutations now routinely include next-generation sequencing (NGS) DNA and matched constitutional from same individual. This allows investigators to control germline polymorphisms distinguish that are unique tumour, thus reducing burden labour-intensive expensive downstream...