A5005637278- Ovarian cancer diagnosis and treatment
- Chromatin Remodeling and Cancer
- Cancer Mechanisms and Therapy
- Cancer Research and Treatments
- Endometrial and Cervical Cancer Treatments
- Protein Degradation and Inhibitors
- Lung Cancer Research Studies
- Virus-based gene therapy research
- RNA modifications and cancer
- Cancer-related Molecular Pathways
- Cancer-related gene regulation
- Cancer Genomics and Diagnostics
- Peptidase Inhibition and Analysis
- Reproductive System and Pregnancy
- Amino Acid Enzymes and Metabolism
- Cervical Cancer and HPV Research
- Histone Deacetylase Inhibitors Research
- Cancer, Hypoxia, and Metabolism
- Immune Cell Function and Interaction
- Epigenetics and DNA Methylation
- Cancer Immunotherapy and Biomarkers
- Genetic factors in colorectal cancer
- Cancer-related molecular mechanisms research
- RNA Research and Splicing
- Mechanisms of cancer metastasis
University of California, Davis
2019-2025
University of California Davis Medical Center
2019-2025
California State University, Sacramento
2024
UCSF Helen Diller Family Comprehensive Cancer Center
2008-2023
University of California, San Francisco
2006-2023
University of Cincinnati
2023
Caris Life Sciences (United States)
2023
USA Mitchell Cancer Institute
2023
University of South Alabama
2023
Washington University in St. Louis
2023
Classification of endometrial carcinomas (ECs) by morphologic features is inconsistent, and yields limited prognostic predictive information. A new system for classification based on the molecular categories identified in The Cancer Genome Atlas proposed. Genomic data from (TCGA) support into four prognostically significant subgroups; we used TCGA set to develop surrogate assays that could replicate classification, but without need labor-intensive cost-prohibitive genomic methodology....
BACKGROUND Classification of endometrial carcinomas (ECs) by morphologic features is irreproducible and imperfectly reflects tumor biology. The authors developed the Proactive Molecular Risk Classifier for Endometrial Cancer (ProMisE), a molecular classification system based on Genome Atlas genomic subgroups, sought to confirm both feasibility prognostic ability in new, large cohort ECs. METHODS Immunohistochemistry (IHC) presence or absence mismatch repair (MMR) proteins (to identify MMR...
The principal reason for failure of targeted cancer therapies is the emergence resistant clones that regenerate tumor. Therapeutic efficacy therefore depends on not only how effectively a drug inhibits its target, but also innate or adaptive functional redundancy target and attendant pathway. In this regard, Myc transcription factors are intriguing therapeutic targets because they serve unique irreplaceable role coordinating expression many diverse genes that, together, required somatic cell...
Abstract Small cell carcinoma of the ovary, hypercalcaemic type ( SCCOHT ) is a lethal and sometimes familial ovarian tumour young women children. We others recently discovered that over 90% SCCOHTs harbour inactivating mutations in chromatin remodelling gene SMARCA4 with concomitant loss its encoded protein BRG1 ), one two mutually exclusive ATPases SWI / SNF complex. To determine specificity for , we examined expression by immunohistochemistry more than 3000 primary gynaecological tumours....
Many women with ovarian endometrioid carcinoma present concurrent endometrial carcinoma. Organ-confined and low-grade synchronous tumors (SEOs) clinically behave as independent primary rather than a single advanced-stage We used 18 SEOs to investigate the ancestral relationship between components. Based on both targeted exome sequencing, 17 of patient cases simultaneous cancer endometrium ovary from our series showed evidence clonal relationship, ie, tumor metastasis. Eleven fulfilled...
Small-cell lung carcinoma (SCLC) is a neuroendocrine subtype of cancer. Although SCLC patients often initially respond to therapy, tumors nearly always recur, resulting in 5-year survival rate less than 10%. A mouse model has been developed based on the fact that RB and p53 tumor suppressor genes are mutated more 90% human SCLCs. Emerging evidence models suggests p130, gene related RB, may act as cells. To test this idea, we used conditional mutant mice delete p130 combination with Rb adult...
<i>Neu</i> (c-<i>erbB2</i>) is a proto-oncogene product that encodes an epidermal growth factor-like receptor tyrosine kinase. Amplification of wild-type c-<i>Neu</i>and mutational activation (<i>Neu T</i>) have been implicated in oncogenic transformation cultured fibroblasts and mammary tumorigenesis <i>in vivo</i>. Here, we examine the relationship between Neu kinase activity caveolin-1 protein expression vitro</i> vivo.</i> Recent studies suggested caveolins may function as negative...
Cell-cycle progression is mediated by a coordinated interaction between cyclin-dependent kinases and their target proteins including the pRB E2F/DP-1 complexes. Immunoneutralization antisense experiments have established that abundance of cyclin D1, regulatory subunit kinases, may be rate-limiting for G 1 phase cell cycle. Simian virus 40 (SV40) small tumor (t) antigen capable promoting augments substantially efficiency SV40 transformation through several distinct domains. In these studies,...
The ubiquitous deregulation of Myc in human cancers makes it an intriguing therapeutic target, a notion supported by recent studies Ras-driven lung tumors showing that inhibiting endogenous triggers tumor regression. However, neither the mechanism nor applicability inhibition to other types driven oncogenic mechanisms is established. Here, we show also regression simian virus 40 (SV40)-driven pancreatic islet model. Such presaged collapse microenvironment and involution vasculature. Hence,...
Abstract Endometriosis is a significant risk factor for clear cell and endometrioid ovarian cancers often found contiguous with these cancers. Using whole‐genome shotgun sequencing of seven carcinomas ( CCC ) targeted in synchronous endometriosis, we have investigated how this carcinoma may evolve from endometriosis. In every case observed multiple tumour‐associated somatic mutations at least one concurrent endometriotic lesion. ARID1A PIK3CA appeared consistently endometriosis when present...