Danila Seidel
A5012922109- Antifungal resistance and susceptibility
- Fungal Infections and Studies
- Lung Cancer Treatments and Mutations
- Plant Pathogens and Fungal Diseases
- Infectious Diseases and Mycology
- Lung Cancer Research Studies
- Fibroblast Growth Factor Research
- Cancer Genomics and Diagnostics
- RNA modifications and cancer
- Neuroendocrine Tumor Research Advances
- Cancer Mechanisms and Therapy
- Cancer-related gene regulation
- HER2/EGFR in Cancer Research
- Pneumocystis jirovecii pneumonia detection and treatment
- Epigenetics and DNA Methylation
- Vaccine Coverage and Hesitancy
- Fungal Biology and Applications
- Ocular Infections and Treatments
- Nail Diseases and Treatments
- Indoor Air Quality and Microbial Exposure
- Medical and Biological Ozone Research
- Yeasts and Rust Fungi Studies
- Neonatal Respiratory Health Research
- COVID-19 epidemiological studies
- Respiratory and Cough-Related Research
University of Cologne
2015-2025
Cologne Excellence Cluster on Cellular Stress Responses in Aging Associated Diseases
2016-2025
University Hospital Cologne
2016-2025
Heinrich Heine University Düsseldorf
2019-2025
Düsseldorf University Hospital
2019-2025
Centro Médico ABC
2025
German Center for Infection Research
2016-2024
Royal Brisbane and Women's Hospital
2022
First Pavlov State Medical University of St. Petersburg
2019
Centrum für Integrierte Onkologie
2018
FGFR1 amplification provides a therapeutic target for squamous cell lung cancer, which is resistant to other targeted cancer drugs.
While genomically targeted therapies have improved outcomes for patients with lung adenocarcinoma, little is known about the genomic alterations which drive squamous cell cancer. Sanger sequencing of tyrosine kinome identified mutations in DDR2 kinase gene 3.8% cancers and lines. Squamous cancer lines harboring were selectively killed by knock-down RNAi or treatment multi-targeted inhibitor dasatinib. Tumors established from a mutant line sensitive to dasatinib xenograft models. Expression...
The pattern of mutations in human lung cancer differs by tumor subtype and is a useful addition to histology for selecting targeted therapy improving patient survival.
Pulmonary large-cell neuroendocrine carcinomas (LCNECs) have similarities with other lung cancers, but their precise relationship has remained unclear. Here we perform a comprehensive genomic (n = 60) and transcriptomic 69) analysis of 75 LCNECs identify two molecular subgroups: "type I LCNECs" bi-allelic TP53 STK11/KEAP1 alterations (37%), II enriched for inactivation RB1 (42%). Despite sharing adenocarcinomas squamous cell carcinomas, no transcriptional was found; instead form distinct...
Pneumonia caused by severe acute respiratory syndrome coronavirus 2 emerged in China at the end of 2019. Because immunomodulation and lymphocyte depletion this virus subsequent administration drugs directed immune system, we anticipated that patients might experience fungal superinfection. We collected data from 186 who had disease-associated pulmonary aspergillosis (CAPA) worldwide during March-August 2020. Overall, 182 were admitted to intensive care unit (ICU), including 180 with distress...
BackgroundWe analyzed whether co-occurring mutations influence the outcome of systemic therapy in ALK-rearranged non-small-cell lung cancer (NSCLC).Patients and methodsALK-rearranged stage IIIB/IV NSCLC patients were with next-generation sequencing fluorescence situ hybridization analyses on a centralized diagnostic platform. Median progression-free survival (PFS) overall (OS) determined total cohort treatment-related sub-cohorts. Cox regression carried out to exclude...
Background The International Society for Human and Animal Mycology (ISHAM) working group proposed recommendations managing allergic bronchopulmonary aspergillosis (ABPA) a decade ago. There is need to update these due advances in diagnostics therapeutics. Methods An international expert was convened develop guidelines ABPA (caused by Aspergillus spp.) mycosis (ABPM; caused fungi other than adults children using modified Delphi method (two online rounds one in-person meeting). We defined...
The effects of climate change and natural disasters on fungal pathogens the risks for diseases remain incompletely understood. In this literature review, we examined how fungi are adapting to an increase in Earth's temperature becoming more thermotolerant, which is enhancing fitness virulence. Climate creating conditions conducive emergence new priming adapt previously inhospitable environments, such as polluted habitats urban areas, leading geographical spread some traditionally non-endemic...
Small cell lung cancer (SCLC) accounts for about 15% of all cancers. The prognosis SCLC patients is devastating and no biologically targeted therapeutics are active in this tumor type. To develop a framework development specific SCLC-targeted drugs we conducted combined genomic pharmacological vulnerability screen lines. We show that lines capture the landscape primary tumors provide genetic predictors activity clinically relevant inhibitors by screening 267 compounds across 44 these Aurora...
Mucormycosis has emerged as a rare but frequently fatal invasive fungal disease. Current knowledge on paediatric mucormycosis is based case reports and small series reported over several decades. Contemporary data large cohort of patients lacking. Two international registries (Zygomyco.net FungiScope™) were searched for cases in ≤19 year-old patients. Cases enrolled between 2005 2014 extracted, dual entries the two databases merged. Epidemiology, clinical characteristics, diagnostic...
Invasive Scedosporium spp. and Lomentospora prolificans infections are an emerging threat in immunocompromised occasionally healthy hosts. is intrinsically resistant to most, L. all the antifungal drugs currently approved, raising concerns about appropriate treatment decisions. High mortality rates of up 90% underline need for comprehensive diagnostic workup even more new, effective improve patient outcome. For a analysis, we identified cases severe from literature diagnosed 2000 or later...
Treatment of EGFR-mutant non-small cell lung cancer patients with the tyrosine kinase inhibitors erlotinib or gefitinib results in high response rates and prolonged progression-free survival. Despite development sensitive mutation detection approaches, a thorough validation these clinical setting has so far been lacking. We performed, setting, systematic dideoxy 'Sanger' sequencing pyrosequencing against massively parallel as one most technologies available. Mutational annotation tumor...
Summary Saprochaete and Geotrichum spp. are rare emerging fungi causing invasive fungal diseases in immunosuppressed patients scarce evidence is available for treatment decisions. Among 505 cases of IFD from the FungiScope ™ registry, we identified 23 infections caused by these reported 10 countries over a 12‐year period. All were adults previous chemotherapy with associated neutropenia was most common co‐morbidity. Fungaemia confirmed 14 (61%) deep organ involvement included lungs, liver,...