Kerstin Albus
A5031380809- Lung Cancer Treatments and Mutations
- Cancer therapeutics and mechanisms
- Fibroblast Growth Factor Research
- Cancer Genomics and Diagnostics
- Colorectal Cancer Treatments and Studies
- Synthesis and biological activity
- Biochemical Analysis and Sensing Techniques
- Epigenetics and DNA Methylation
- Vaccine Coverage and Hesitancy
- HER2/EGFR in Cancer Research
- Eating Disorders and Behaviors
- Ethics in Clinical Research
- Lung Cancer Research Studies
- Pneumonia and Respiratory Infections
- Diabetes Management and Research
- Chemical Synthesis and Analysis
- Health Systems, Economic Evaluations, Quality of Life
- Neonatal Respiratory Health Research
- Synthesis and Reactions of Organic Compounds
- RNA modifications and cancer
- Misinformation and Its Impacts
- Cytokine Signaling Pathways and Interactions
- Zoonotic diseases and public health
- Diabetes Treatment and Management
- Diet and metabolism studies
Cologne Excellence Cluster on Cellular Stress Responses in Aging Associated Diseases
2018-2025
University of Cologne
2013-2025
University Hospital Cologne
2012-2025
German Center for Infection Research
2023
Heinrich Heine University Düsseldorf
2022-2023
Düsseldorf University Hospital
2022-2023
Integrated Oncology (United States)
2022-2023
University Hospital Bonn
2015
Max Planck Institute for Metabolism Research
2013
TU Dortmund University
2013
The pattern of mutations in human lung cancer differs by tumor subtype and is a useful addition to histology for selecting targeted therapy improving patient survival.
To identify novel mechanisms of resistance to third-generation EGFR inhibitors in patients with lung adenocarcinoma that progressed under therapy either AZD9291 or rociletinib (CO-1686).
Western diets rich in fat and sugar promote excess calorie intake weight gain; however, the underlying mechanisms are unclear. Despite a well-documented association between obesity altered brain dopamine function, it remains elusive whether these alterations (1) pre-existing, increasing individual susceptibility to gain, (2) secondary obesity, or (3) directly attributable repeated exposure western diet. To close this gap, we performed randomized, controlled study (NCT05574660) with...
Small cell lung cancers (SCLCs) and extrapulmonary small (SCCs) are very aggressive tumors arising de novo as primary cancer with characteristic genetic lesions in RB1 TP53. Based on murine models, neuroendocrine stem cells of the terminal bronchioli have been postulated cellular origin SCLC. However, both many other organs, combined cell/non-small secondary transitions from non-small carcinomas upon therapy to occur. We define features "small cell-ness" based markers, TP53 mutations...
We recently reported fibroblast growth factor receptor-type 1 (FGFR1) amplification to be associated with therapeutically tractable FGFR1 dependency in squamous cell lung cancer. This makes a novel target for directed therapy these tumors. To reproducibly identify patients clinical studies, we developed standardized reading and evaluation strategy fluorescence in-situ hybridization (FISH) propose criteria, describe different patterns of low- high-level amplifications report on the prevalence...
Somatic mutations of the PIK3CA gene have been described in non-small cell lung cancer (NSCLC), but limited data is available on their biological relevance. This study was performed to characterize PIK3CA-mutated NSCLC clinically and genetically.Tumor tissue collected consecutively from 1144 patients within a molecular screening network between March 2010 2012 analyzed for using dideoxy-sequencing next-generation sequencing (NGS). Clinical, pathological, genetic characteristics are compared...
Survival under selective pressure is driven by the ability of our brain to use sensory information advantage control physiological needs. To that end, neural circuits receive and integrate external environmental cues internal metabolic signals form learned associations, consequently motivating adapting behaviour. The dopaminergic midbrain plays a crucial role in learning adaptive behaviour particularly sensitive peripheral signals, including intestinal peptides, such as glucagon-like peptide...
The 8p12 locus (containing the FGFR1 tyrosine kinase gene) is frequently amplified in squamous cell lung cancer. However, it currently unknown which of 8p12-amplified tumors are also sensitive to fibroblast growth factor receptor (FGFR) inhibition. We found that, contrast with other recurrent amplifications, region included multiple centers amplification, suggesting marked genomic heterogeneity. FGFR1-amplified tumor cells were dependent on FGFR ligands vitro and vivo. Furthermore, ectopic...
The coronavirus disease 2019 (COVID-19) pandemic has evidenced the key role of vaccine design, obtention, production and administration to successfully fight against infectious diseases provide efficient remedies for citizens. Although clinical trials were rapidly established during this pandemic, identifying suitable study subjects can be challenging. For reason, University Hospital Cologne a volunteer registry participation in first Germany, which now been incorporated into European...
The World Health Organization (WHO)'s Research and Development (R&D) Blueprint for Action to Prevent Epidemics, a plan of action, highlighted several infectious diseases as crucial targets prevention. These infections were selected based on thorough assessment factors such transmissibility, infectivity, severity, evolutionary potential. In line with this blueprint, the VACCELERATE Site Network approached disease experts rank listed in WHO R&D according their perceived risk triggering...
To regulate food intake, our brain constantly integrates external cues, such as the incentive value of a potential reward, with internal state signals, hunger feelings. Incentive motivation refers to processes that translate an expected reward into effort spent obtain reward; magnitude and probability involved in prompting motivated behaviour are encoded by dopaminergic (DA) midbrain its mesoaccumbens DA projections. This type circuity is particularly sensitive metabolic signalled peripheral...
Feeding behavior must be continuously adjusted to match energy needs. Recent discoveries in murine models identified uridine as a regulator of balance. Here, we explore its contribution the complex control food intake humans by administering single dose monophosphate (UMP; 0.5 or 1 g) healthy participants two placebo-controlled studies designed assess (registration: DRKS00014874). We establish that endogenous circulating correlates with hunger and ensuing consumption. It also dynamically...
The inconsistent European vaccine trial landscape rendered the continent of limited interest for developers. VACCELERATE consortium created a network capable clinical sites throughout Europe. identifies and provides access to state-of-the-art accelerate development vaccines.Login details Site Network (vaccelerate.eu/site-network/) questionnaire can be obtained after sending an email to. Interested provide basic information, such as contact details, affiliation with infectious disease...
Aims: VIAject ® is a formulation of human insulin with very fast onset action. Previous studies used in concentration 25 U/ml and pH 4 [VIAject (VJ25)]. Objective this double blind, three‐way crossover study was to compare the pharmacodynamic/pharmacokinetic properties novel 100 neutral 7 (VJ7)] VJ25 lispro (LIS). Methods: Forty‐three patients type 1 diabetes [aged 43 (21–65) years, BMI 24.1 (20–28) kg/m 2 HbA1c 7.5 (5.7–9.5) %] participated study. They received subcutaneous injections 12 U...
Evaluation of postprandial glycemic excursions in patients with type 1 diabetes three prandial insulins: VIAject™ (Linjeta™), an ultra-fast insulin (UFI); lispro (LIS); and regular human (RHI).
// Jakob Schöttle 1,2,3 , Sampurna Chatterjee 1,2,10 Caroline Volz 1,2 Maike Siobal 2 Alexandra Florin 4 Dennis Rokitta 5 Yvonne Hinze 6 Felix Dietlein 3 Plenker Katharina König Kerstin Albus Johannes M. Heuckmann 7 Daniel Rauh 8 Thomas Franz Bernd Neumaier 2,9 Uwe Fuhr Lukas C. Heukamp 4,7 and Roland T. Ullrich 1 Department I of Internal Medicine, Center Integrated Oncology Köln-Bonn, University Cologne, Germany Molecular Medicine Cologne (ZMMK), Max-Planck-Institute for Metabolism, with...
Background The pan-European VACCELERATE network aims to implement the first transnational harmonized and sustainable vaccine trial Volunteer Registry, being a single entry point for potential volunteers of large-scale trials across Europe. This work exhibits set trial–related educational promotional tools general public, designed disseminated by network. Objective study primarily aimed design develop standard toolkit increase positive attitudes access trustworthy information better increased...
Underserved and hard-to-reach population groups are under-represented in vaccine trials. Thus, we aimed to identify the challenges of trial participation these member countries VACCELERATE network. Seventeen National Coordinators (NC), each representing their respective country (15 European countries, Israel, Turkey), completed an online survey. From 15 eligible groups, those that were more frequently declared underserved/hard-to-reach research ethnic minorities (76.5%), persons experiencing...
Zusammenfassung Hintergrund Trotz der stetig zunehmenden Adipositasepidemie ist das konservative Therapieangebot für schwerstadipöse Patienten begrenzt, sodass die Poliklinik Endokrinologie Uniklinik Köln gemäß den Gemeinsamen Empfehlungen Ersatzkassen interdisziplinäre Patientenschulungsprogramm „Change your Life!“ (CyL) eine langfristige Lebensstiländerung und Gewichtsreduktion entworfen hat. Ziel vorliegenden Studie waren Evaluation des Schulungsprogramms sowie sein Wirksamkeitsnachweis....