A5090098572- Antifungal resistance and susceptibility
- Fungal Infections and Studies
- SARS-CoV-2 and COVID-19 Research
- Neutropenia and Cancer Infections
- Surgical site infection prevention
- COVID-19 Clinical Research Studies
- Pneumocystis jirovecii pneumonia detection and treatment
- COVID-19 and healthcare impacts
- Immunodeficiency and Autoimmune Disorders
- Cancer Immunotherapy and Biomarkers
- Vaccine Coverage and Hesitancy
- Chronic Lymphocytic Leukemia Research
- Immunotherapy and Immune Responses
- Viral gastroenteritis research and epidemiology
- Cardiac, Anesthesia and Surgical Outcomes
- Respiratory viral infections research
- Influenza Virus Research Studies
- Infectious Diseases and Mycology
- Plant Pathogens and Fungal Diseases
- Orthopedic Infections and Treatments
- Antimicrobial Resistance in Staphylococcus
- COVID-19 epidemiological studies
- Hematological disorders and diagnostics
- Infective Endocarditis Diagnosis and Management
- Pneumonia and Respiratory Infections
Cologne Excellence Cluster on Cellular Stress Responses in Aging Associated Diseases
2017-2025
University of Cologne
2017-2025
German Center for Infection Research
2017-2025
University Hospital Cologne
2017-2025
Heinrich Heine University Düsseldorf
2019-2025
Düsseldorf University Hospital
2019-2025
Universität Hamburg
2021-2024
University Medical Center Hamburg-Eppendorf
2021-2024
Centrum für Integrierte Onkologie
2018-2024
Integrated Oncology (United States)
2023-2024
Invasive Scedosporium spp. and Lomentospora prolificans infections are an emerging threat in immunocompromised occasionally healthy hosts. is intrinsically resistant to most, L. all the antifungal drugs currently approved, raising concerns about appropriate treatment decisions. High mortality rates of up 90% underline need for comprehensive diagnostic workup even more new, effective improve patient outcome. For a analysis, we identified cases severe from literature diagnosed 2000 or later...
Candida species frequently cause blood stream infections and are reported to be the third tenth most commonly isolated pathogens. Guidelines standardised treatment algorithms provided by professional organisations aim facilitate decision-making regarding diagnosis, management of candidaemia. In routine clinical practise, however, it may challenging comply with these guidelines. The reasons include lack familiarity or feasibility adherence, but also their length complexity. There is no tool...
Isavuconazole is a novel antifungal drug approved for the treatment of adults with invasive aspergillosis and mucormycosis. While azoles as class effect are known to prolong QTc interval, clinical trials have shown that isavuconazole administration may cause shortening in dose-related manner. Here, we assessed effects on length interval. The objective study was describe changes interval induced by treatment. A total 26 adult patients from 7 hospitals were included. Patients received fungal...
The coronavirus disease 2019 (COVID-19) pandemic has evidenced the key role of vaccine design, obtention, production and administration to successfully fight against infectious diseases provide efficient remedies for citizens. Although clinical trials were rapidly established during this pandemic, identifying suitable study subjects can be challenging. For reason, University Hospital Cologne a volunteer registry participation in first Germany, which now been incorporated into European...
Invasive pulmonary aspergillosis is a serious threat to immunocompromised and critical care patients. Recent detailed guidelines treatment algorithms lead microbiologists clinicians in diagnosis of invasive aspergillosis. Currently, there no tool available that allows measure guideline adherence. To develop such tool, we reviewed current provided by five scientific societies (European Society for Clinical Microbiology Infectious Diseases, European Confederation Medical Mycology, Respiratory...
Abstract Background First-line antifungal treatment for invasive mucormycosis (IM) consists of liposomal amphotericin B. Salvage options are limited and often based on posaconazole oral suspension. With the approval new formulations, patients could benefit from improved pharmacokinetics, safety tolerability. Objectives Our aim was to assess effectiveness formulations IM treatment. Methods We performed a case-matched analysis with proven or probable FungiScope® Registry. (1st-POSnew)...
Since its first detection in China late 2019 the novel severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and associated infectious disease COVID-19 continue to have a major impact on global healthcare clinical practice. Cancer patients, particular those with haematological malignancies, seem be at an increased risk for course of infection. Deliberations avoid or defer potentially immunosuppressive therapies these patients need balanced against overarching goal providing optimal...
Summary Objectives Candidemia is among the most frequent nosocomial bloodstream infections. Landmark case‐control studies on amphotericin B and fluconazole estimated attributable mortality rates of 38% 49%, respectively. After introduction echinocandins, these may have decreased. Methods In a design, 100 consecutive, hospitalised patients with candidemia were enrolled at University Hospital Cologne, Germany between 2014 2017. Controls without matched for age, sex, year duration...
Abstract In response to the COVID-19 pandemic, multiple vaccines were developed using platforms such as viral vectors and mRNA technology. Here, we report humoral cellular immunogenicity data from human phase 1 clinical trials investigating two recombinant Modified Vaccinia virus Ankara vaccine candidates, MVA-SARS-2-S MVA-SARS-2-ST, encoding native prefusion-stabilized SARS-CoV-2 spike protein, respectively. MVA-SARS-2-ST was more immunogenic than MVA-SARS-2-S, but both less compared...
Mucormycosis is a life-threatening infection in immunocompromised patients and haematological malignancy particular. Our aim was to develop evaluate scoring tool measure adherence current guidelines for mucormycosis. Current of scientific societies on mucormycosis management were reviewed. We assembled diagnostic, treatment follow-up milestones designed the EQUAL Score. The Score evaluated ECMM Excellence Centres. An 18-item with one three points per item resulted maximum achievable score...