A5058592648- Infective Endocarditis Diagnosis and Management
- Infection Control in Healthcare
- Antimicrobial Resistance in Staphylococcus
- Antibiotic Use and Resistance
- Bacterial Identification and Susceptibility Testing
- Poxvirus research and outbreaks
- Herpesvirus Infections and Treatments
- Psychoanalysis and Social Critique
- Health and Medical Studies
- Respiratory viral infections research
- Medical History and Research
- COVID-19 Clinical Research Studies
- Pneumonia and Respiratory Infections
- Antibiotics Pharmacokinetics and Efficacy
- Orthopedic Infections and Treatments
- Parasitic infections in humans and animals
- Psychiatric care and mental health services
- Amoebic Infections and Treatments
- Parvovirus B19 Infection Studies
- Viral Infections and Outbreaks Research
- Child and Adolescent Health
- Viral Infections and Vectors
- Streptococcal Infections and Treatments
- Trypanosoma species research and implications
- Bacillus and Francisella bacterial research
Charité - Universitätsmedizin Berlin
2016-2025
Humboldt-Universität zu Berlin
2019-2025
Freie Universität Berlin
2019-2025
University Hospital Complex Of Vigo
2022
Ospedali Riuniti San Giovanni di Dio e Ruggi d'Aragona
2019
Arsi University
2017
Heinrich Heine University Düsseldorf
2015-2017
Düsseldorf University Hospital
2015
University of Tübingen
2005
Technische Hochschule Ulm
1997
Abstract Berlin is amongst the cities most affected by current monkeypox outbreak. Here, we report clinical characteristics of first patients with confirmed admitted to our center. We analyzed anamnestic, clinical, and laboratory data. Within a period 2 weeks, six were hospitalized in unit. All MSM had practiced condomless receptive anal intercourse weeks preceding admission. The chief complaint all but one was severe pain unprecedented severity. Investigations revealed proctitis, as well...
Abstract Background Cases of mpox have been reported worldwide since May 2022. Limited knowledge exists regarding the long-term course this disease. To assess sequelae in terms scarring and quality life (QoL) patients 4–6 months after initial infection. Methods Prospective observational study on clinical characteristics symptoms with polymerase chain reaction (PCR)-confirmed mpox, including both outpatients inpatients. Follow-up visits were conducted at months, assessing Patient Observer...
The burden of health-care associated infections in low-income countries is high. Adequate hand hygiene considered the most effective measure to reduce transmission nosocomial pathogens. We aimed assess compliance with and perception knowledge about before after implementation a multimodal campaign designed by World Health Organization.The study was carried out at Asella Teaching Hospital, university hospital referral centre for population 3.5 million Arsi Zone, Central Ethiopia. Compliance...
Abstract Genome sequences from 47 monkeypox virus infections detected in a German university virology laboratory were analyzed context of other the 2022 outbreak and earlier genomes. Identical non-synonymous amino acid changes six genes signature APOBEC editing match European outbreak. Non-synonymous that present one to three found 34 genes. In two lesions patient, an 856 nucleotide translocation between genome termini resulted duplication initial 5’ gene, disruption or complete deletion...
Human immunodeficiency virus (HIV) continues to be a major global public health issue and omnipresent sexually transmitted infections (STIs) increase the risk of HIV acquisition. Moreover, STIs in pregnant women can harm unborn child. In this study, we systematically investigated prevalence HIV, relevant vaginal group B streptococcus colonization among presenting at Asella Teaching Hospital central Ethiopia their effect on perinatal mortality. A follow-up was performed six weeks after...
Abstract Background First-line antifungal treatment for invasive mucormycosis (IM) consists of liposomal amphotericin B. Salvage options are limited and often based on posaconazole oral suspension. With the approval new formulations, patients could benefit from improved pharmacokinetics, safety tolerability. Objectives Our aim was to assess effectiveness formulations IM treatment. Methods We performed a case-matched analysis with proven or probable FungiScope® Registry. (1st-POSnew)...
Adequate patient allocation is pivotal for optimal resource management in strained healthcare systems, and requires detailed knowledge of clinical virological disease trajectories. The purpose this work was to identify risk factors associated with need invasive mechanical ventilation (IMV), analyse viral kinetics patients without IMV provide a comprehensive description course.A cohort 168 hospitalised adult COVID-19 enrolled prospective observational study at large European tertiary care...
Introduction Acute outbreaks of novel virus caused diseases like coronavirus disease 2019 (COVID-19) challenge the national and international healthcare systems specifically emergency departments (EDs) as patients, even if they have only mild symptoms, intuitively present in ED once fear to a serious disease. Therefore, EDs need prepare fast effectively address walk-in patients who might transmit SARS-CoV-2 without displaying severe symptoms themselves, protect personnel vulnerable patient...
Rothia sp. are Gram-positive bacteria in the class of Actinobacteria that part physiological oral flora. In rare cases, aeria and dentocariosa can cause infective endocarditis (IE). The biofilm potential is unknown. Specimen from two cases were obtained during cardiac surgery. One patients suffered mitral valve IE aeria. other case, a prosthetic pulmonary was caused by dentocariosa. Fluorescence situ hybridization (FISH) used for visualization microorganisms within heart tissues combination...
Artemisinin-based combination therapy (ACT) for the treatment of malaria is highly effective, well tolerated and safe. Episodes delayed haemolysis occur in up to 57.9% patients with severe treated intravenous artesunate, mainly caused by 'pitting' infected red blood cells spleen loss these once-infected RBCs (oiRBCs). Several reports indicate that post-treatment (PTH) also occurs uncomplicated oral ACT, calling systematic investigation.A prospective observational study identify incidence PTH...
Abstract Purpose To investigate antimicrobial use and primary nosocomial infections in hospitalized COVID-19 patients to provide data for guidance of therapy. Methods Prospective observational cohort study conducted at Charité–Universitätsmedizin Berlin, including with SARS-CoV-2-infection between March November 2020. Results 309 were included, 231 directly admitted 78 transferred from other centres. Antimicrobial therapy was initiated 62/231 (26.8%) 44/78 (56.4%) patients. The rate...
The microbial etiology of prosthetic valve infective endocarditis (PVE) can be difficult to identify. Our aim was investigate the benefit molecular imaging technique fluorescence in situ hybridization (FISH) combined with 16S rRNA-gene polymerase chain reaction (PCR) and sequencing (FISHseq) for analysis infected heart valves.We retrospectively evaluated diagnostic outcome 113 valves from 105 patients suspected PVE, treated 2003-2013 Department Cardiac Surgery, Charité University Medicine...
Abstract Therapy choices for cystic echinococcisis (CE) are stage-specific: surgical, minimally invasive, medical or observation without intervention. PAIR (percutaneous aspiration, instillation of a scolicide, and re-aspiration) has been considered the treatment choice uncomplicated echinococcal liver cysts. However, carries risk toxic cholangitis hypernatremia that cyst frequently refills with bile after withdrawing catheter. We treated patient giant CE 1 puncture drainage (PD) under...
(1) Background: The successful treatment of infective endocarditis (IE) relies on detecting causative pathogens to administer targeted antibiotic therapy. In addition standard microbiological cultivation from tissue obtained during heart valve surgery, the potential molecular biological methods was evaluated. (2) Methods: A retrospective study performed 207 patients who underwent surgery for IE. FISHseq (fluorescence in situ hybridization combined with 16S rRNA gene PCR and sequencing)...
Mycobacterium chelonae is a rare cause of infective endocarditis that difficult to diagnose and treat. After we found M in series patients, aimed investigate its role cardiovascular prosthesis dysfunction contamination bioprostheses as possible infection.
Introduction Patients with high-consequence infectious diseases (HCID) are rare in Western Europe. However, high-level isolation units (HLIU) must always be prepared for patient admission. Case fatality rates of HCID can reduced by providing optimal intensive care management. We here describe a single centre’s preparation, its embedding the national context and challenges we faced during severe acute respiratory syndrome coronavirus type 2 (SARS-CoV-2) pandemic. Methods Ten team leaders...
The burden of health-care associated infections (HAI) in low-income countries is high. Adequate hand hygiene considered the most effective measure to reduce transmission nosocomial pathogens.
The prevalence and mortality rates of severe infections are high in intensive care units (ICUs). At the same time, pharmacokinetic variability observed ICU patients increases risk inadequate antibiotic drug exposure. Therefore, dosing tailored to specific patient characteristics has a potential improve outcomes this vulnerable population. This study aimed develop tabular decision tool for initial therapy meropenem integrating hospital-specific, thus far unexploited pathogen susceptibility...