A5060098115- Malaria Research and Control
- Trypanosoma species research and implications
- Retinal Development and Disorders
- Photoreceptor and optogenetics research
- Photochromic and Fluorescence Chemistry
- HIV/AIDS drug development and treatment
- Aquaculture disease management and microbiota
- Hemoglobinopathies and Related Disorders
- Mosquito-borne diseases and control
Humboldt-Universität zu Berlin
2022-2025
Charité - Universitätsmedizin Berlin
2022-2025
Freie Universität Berlin
2022-2025
Australian National University
2022
German Center for Neurodegenerative Diseases
2021
Using retinal organoid systems, organ-like 3D tissues, relies implicitly on their robustness. However, essential key parameters, particularly growth and longer-term culture, are still insufficiently defined. Here, we hypothesize that a previously optimized protocol for high yield of evenly-sized mouse organoids with low variability facilitates assessment such parameters. We demonstrate these reliably complete retinogenesis, can be maintained at least up to 60 days in culture. During this...
Artemisinin-based combination therapy (ACT) for the treatment of malaria is highly effective, well tolerated and safe. Episodes delayed haemolysis occur in up to 57.9% patients with severe treated intravenous artesunate, mainly caused by 'pitting' infected red blood cells spleen loss these once-infected RBCs (oiRBCs). Several reports indicate that post-treatment (PTH) also occurs uncomplicated oral ACT, calling systematic investigation.A prospective observational study identify incidence PTH...
After two consecutive AL treatment failures in a non-immune traveller returning from Uganda with Plasmodium falciparum malaria, the parasite showed artemisinin resistance ex vivo and vitro, but no associated genetic markers pfK13 or pfcoronin. In vitro evidence for increased lumefantrine tolerance was present, as were pfmdr1 alleles.