Victoria Zismann
A5000330909- Chromatin Remodeling and Cancer
- Cancer Mechanisms and Therapy
- Veterinary Oncology Research
- Protein Degradation and Inhibitors
- Infectious Diseases and Mycology
- Peptidase Inhibition and Analysis
- Virus-based gene therapy research
- Cancer Genomics and Diagnostics
- DNA Repair Mechanisms
- Gene expression and cancer classification
- Genetic Associations and Epidemiology
- Plant Disease Resistance and Genetics
- Cancer-related gene regulation
- Cutaneous Melanoma Detection and Management
- Melanoma and MAPK Pathways
- Cancer therapeutics and mechanisms
- Colorectal Cancer Treatments and Studies
- Bioinformatics and Genomic Networks
- Chemical Synthesis and Analysis
- Cancer-related Molecular Pathways
- Alzheimer's disease research and treatments
- Plant Pathogens and Fungal Diseases
- Genomics and Phylogenetic Studies
- Genomic variations and chromosomal abnormalities
- Genomics and Rare Diseases
Translational Genomics Research Institute
2014-2025
City Of Hope National Medical Center
2022-2023
City of Hope
2022-2023
Arizona State University
2014
Arizona Alzheimer’s Consortium
2007-2009
Alzheimer's Association
2007-2009
University of Arkansas for Medical Sciences
2008
Duke University
2008
University of North Carolina at Chapel Hill
2008
Center for Human Genetics
2008
Article Abstract Objective: While the apolipoprotein E (APOE) e4 allele is a well-established risk factor for late-onset Alzheimer's disease (AD), initial genome scans using microsatellite markers in AD failed to identify this locus on chromosome 19. Recently developed methods simultaneous assessment of hundreds thousands single nucleotide polymorphisms (SNPs) promise help more precisely loci that contribute and other common multigenic conditions. We sought here demonstrate precise...
So far, two genes associated with familial melanoma have been identified, accounting for a minority of genetic risk in families. Mutations CDKN2A account approximately 40% cases, and predisposing mutations CDK4 reported very small number kindreds. Here we report the whole-genome sequencing probands from several families, which performed order to identify other melanoma. We one individual carrying novel germline variant (coding DNA sequence c.G1075A; protein p.E318K; rs149617956)...
Rice is the world's most important food crop and a model for cereal research. At 430 megabases in size, its genome compact of cereals. We report sequence chromosome 10, smallest 12rice chromosomes (22.4 megabases), which contains 3471 genes. Chromosome 10 considerable heterochromatin with an enrichment repetitive elements on 10S expressed genes 10L. Multiple insertions from organellar genomes were detected. Collinearity was apparent between rice sorghum maize. Comparison draft finished...
ABSTRACT Most of the 3,000 named species in genus Cercospora have no known sexual stage, although a Mycosphaerella teleomorph has been identified for few. is an extremely large and important plant pathogens, with more than 1,800 at least 43 associated anamorph genera. The goal this research was to perform large-scale phylogenetic analysis test hypotheses about past evolutionary history Mycosphaerella. Based on internal transcribed spacer (ITS) sequence data (ITS1, 5.8S rRNA gene, ITS2),...
Genomic analyses of cutaneous melanoma (CM) have yielded biological and therapeutic insights, but understanding non-ultraviolet (UV)-derived CMs remains limited. Deeper analysis acral lentiginous (ALM), a rare sun-shielded subtype associated with worse survival than CM, is needed to delineate non-UV oncogenic mechanisms. We thus performed comprehensive genomic transcriptomic 34 ALM patients. Unlike somatic alterations were dominated by structural variation absence UV-derived mutation...
Abstract Osteosarcoma (OS) is a rare, metastatic, human adolescent cancer that also occurs in pet dogs. To define the genomic underpinnings of canine OS, we performed multi-platform analysis OS tumors from 59 dogs, including whole genome sequencing ( n = 24) and exome (WES; 13) primary matched normal tissue, WES 10) primary/metastatic/normal samples RNA 54) tumors. We found recapitulates features low point mutation burden (median 1.98 per Mb) with trend towards higher metastases, high...
Matching molecularly targeted therapies with cancer subtype-specific gene mutations is revolutionizing oncology care. However, for rare cancers this approach problematic due to the often poor understanding of disease's natural history and phenotypic heterogeneity, making treatment these a particularly unmet medical need in clinical oncology. Advanced Sézary syndrome (SS), an aggressive, exceedingly variant cutaneous T-cell lymphoma (CTCL) prototypical example cancer. Through whole genome RNA...
Canine malignant melanoma, a significant cause of mortality in domestic dogs, is powerful comparative model for human but little known about its genetic etiology. We mapped the genomic landscape canine melanoma through multi-platform analysis 37 tumors (31 mucosal, 3 acral, 2 cutaneous, and 1 uveal) 17 matching constitutional samples including long- short-insert whole genome sequencing, RNA array hybridization, single nucleotide polymorphism array, targeted Sanger sequencing analyses....
Abstract Purpose: Small cell carcinoma of the ovary, hypercalcemic type (SCCOHT) is a rare, aggressive ovarian cancer in young women that universally driven by loss SWI/SNF ATPase subunits SMARCA4 and SMARCA2. A great need exists for effective targeted therapies SCCOHT. Experimental Design: To identify underlying therapeutic vulnerabilities SCCOHT, we conducted high-throughput siRNA drug screens. Complementary proteomics approaches profiled kinases inhibited ponatinib. Ponatinib was tested...
Small cell carcinoma of the ovary, hypercalcemic type (SCCOHT), is a rare and understudied cancer with dismal prognosis. SCCOHT's infrequency has hindered empirical study its biology clinical management. However, we others have recently identified inactivating mutations in SWI/SNF chromatin remodeling gene SMARCA4 concomitant loss protein majority SCCOHT tumors.(1-4) Here summarize these findings report status by targeted sequencing and/or immunohistochemistry (IHC) an additional 12 tumors,...
Alzheimer’s disease (AD) is a neurodegenerative disorder characterized by progressively disabling impairments in memory, cognition, and non-cognitive behavioural symptoms. Sporadic AD multifactorial genetically complex. While several monogenic mutations cause early-onset gene alleles have been suggested as susceptibility factors, the only extensively validated for late-onset apolipoprotein E (<i>APOE)</i> &#917;4 allele. Alleles of <i>APOE</i> do not account all...
Abstract Purpose: Naturally occurring primary canine lung cancers share clinicopathologic features with human in never-smokers, but the genetic underpinnings of cancer are unknown. We have charted genomic landscape and performed functional characterization novel, recurrent HER2 (ERBB2) mutations pulmonary adenocarcinoma (cPAC). Experimental Design: multiplatform sequencing 88 tumors or cell lines. Additionally, cPAC lines, we signaling evaluated mutation-dependent inhibitor drug...
Small cell carcinoma of the ovary-hypercalcemic type (SCCOHT) is a rare ovarian cancer affecting young females and driven by loss both SWI/SNF ATPases SMARCA4 SMARCA2. As alters enhancers, we hypothesized that super-enhancers, which regulate oncogene expression in cancer, are disparately impacted loss. We discovered differences between occupancy at enhancers vs. super-enhancers. SCCOHT super-enhancer target genes were enriched developmental processes, most notably nervous system development....
Pooling genomic DNA samples within clinical classes of disease followed by genotyping on whole-genome SNP microarrays, allows for rapid and inexpensive genome-wide association studies. Key to the success these studies is accuracy allelic frequency calculations, ability identify false-positives arising from assay variability better resolve signals through analysis neighbouring SNPs.We report measurements pooled comparing known frequencies as determined individual genotyping. We describe...