A5004760489- Nuclear Structure and Function
- RNA and protein synthesis mechanisms
- Spondyloarthritis Studies and Treatments
- RNA Research and Splicing
- Protein Structure and Dynamics
- Cancer Genomics and Diagnostics
- Genetic factors in colorectal cancer
- Cancer-related molecular mechanisms research
- Cervical Cancer and HPV Research
- vaccines and immunoinformatics approaches
- Cancer-related Molecular Pathways
- Systemic Lupus Erythematosus Research
- Immunotherapy and Immune Responses
- Nonmelanoma Skin Cancer Studies
- Genomics and Rare Diseases
- Viral-associated cancers and disorders
- Multiple and Secondary Primary Cancers
- Autoimmune and Inflammatory Disorders Research
- Cellular Mechanics and Interactions
- Genetic and Clinical Aspects of Sex Determination and Chromosomal Abnormalities
- Gene Regulatory Network Analysis
- Genetic Syndromes and Imprinting
- Monoclonal and Polyclonal Antibodies Research
- Inflammasome and immune disorders
- Lung Cancer Diagnosis and Treatment
Queensland University of Technology
2019-2023
Translational Research Institute
2016-2022
The University of Queensland
2010-2016
AgriBio
2015
QIMR Berghofer Medical Research Institute
2013-2014
Macquarie University
2010
University of Sussex
2006-2007
A data set of 89 protein-RNA complexes has been extracted from the Protein Data Bank, and nucleic acid recognition sites characterized through direct contacts, accessible surface area, secondary structure motifs. The differences between RNA that bind to RNAs in functional classes also analyzed. Analysis complete revealed van der Waals interactions are more numerous than hydrogen bonds contacts made backbone occur frequently specific nucleotide bases. Of base-specific were observed, guanine...
Smchd1 is an epigenetic modifier essential for X chromosome inactivation: female embryos lacking fail during midgestational development. Male mice are less affected by Smchd1-loss, with some (but not all) surviving to become fertile adults on the FVB/n genetic background. On other backgrounds, all males die perinatally. This suggests that, in addition being critical inactivation, functions control expression of autosomal genes.Using genome-wide microarray profiling and RNA-seq, we have...
Objective We undertook this study to evaluate the activation and functional relevance of inflammasome pathways in ankylosing spondylitis (AS) patients rodent models their relationship dysbiosis. Methods An pathway was evaluated gut peripheral blood from 40 AS using quantitative reverse transcriptase–polymerase chain reaction (qRT‐PCR), immunohistochemistry (IHC), flow cytometry, confocal microscopy, compared that 20 healthy controls 10 with Crohn’s disease. Bacteria visualized silver stain...
CD4+ T-cell epitopes play a crucial role in eliciting vigorous protective immune responses during peptide (epitope)-based vaccination. The prediction of these focuses on the binding process by MHC class II proteins. ability to account for polymorphism is critical epitope-based vaccine design tools, as different allelic variants can have repertoires. In addition, specificity T-cells often directed very limited set immunodominant peptides pathogen predict what are most likely dominate an...
Abstract Approximately half of the familial aggregation breast cancer remains unexplained. A multiple-case family exome-sequencing study identified three likely pathogenic mutations in RINT1 (NM_021930.4) not present public sequencing databases: c.343C>T (p.Q115X), c.1132_1134del (p.M378del), and c.1207G>T (p.D403Y). On basis this finding, a population-based case–control mutation-screening was conducted that 29 carriers rare (minor allele frequency < 0.5%), variants: 23...
Predikin is a system for making predictions about protein kinase specificity. It was declared the "best performer" in section of Peptide Recognition Domain specificity prediction category recent DREAM4 challenge (an independent test using unpublished data). In this article we discuss some improvements to web server — including more streamlined approach substrate-to-kinase and whole-proteome give an analysis Predikin's performance challenge. We also evaluate these data set yeast kinases that...
Abstract Many protein–RNA recognition events are known to exhibit conformational changes from qualitative observations of individual complexes. However, a quantitative estimation is required if docking and template‐based methods for RNA binding site prediction be developed. This study presents the first quantitive evaluation that occur when proteins bind RNA. The analysis twelve RNA‐binding in bound unbound states using error‐scaled difference distance matrices presented. residues mapped...
Phosphorylation by the cyclin-dependent kinase 1 (Cdk1) adjacent to nuclear localization signals (NLSs) is an important mechanism of regulation nucleocytoplasmic transport. However, no systematic survey has yet been performed in human cells analyze this regulatory process, and corresponding cell-cycle dynamics have not investigated. Here, we focused on proteome found that numerous proteins, previously identified context, are associated with Cdk1-dependent phosphorylation sites their NLSs....
Background Although the majority of human papillomavirus (HPV) infections are cleared by immune system, a small percentage them progress to develop HPV‐driven cancers. Cervical cancer studies highlight that HPV persistence and risk associated with genetic factors, especially at leukocyte antigen (HLA) genes. This study was conducted investigate such associations in head neck (HNC). Methods In all, 192 patients HNC 384 controls were genotyped Infinium Global Screening Array (Illumina, Inc)....
Ever since the ground-breaking work of Anfinsen et al. in which a denatured protein was found to refold its native state, it has been frequently stated by fold prediction community that all information required for folding lies amino acid sequence. Recent vitro experiments and silico computational studies, however, have shown cotranslation may affect pathway some proteins, especially those ancient folds. In this paper aspects cotranslational incorporated into structure algorithm adapting...
Solid organ transplant recipients (SOTRs) have elevated risks for basal cell carcinoma (BCC) and squamous (SCC), especially in high UVR environments. We assessed whether polygenic risk scores can improve the prediction of BCC SCC multiplicity over above traditional factors SOTRs a UV setting. built (n = 594,881) 581,431) using UK Biobank 23andMe datasets, validated them Australian QSkin Sun Health Study cohort > 6,300), applied skin tumor allograft from Queensland, Australia, environment....
Abstract BACKGROUND. The Wnt signalling pathway is altered in the majority of colorectal cancers by APC mutation. Cancers arising via serrated neoplasia are hallmarked BRAF mutation and microsatellite instability (MSI), but do not commonly mutate APC. RNF43 ZNRF3 transmembrane E3 ubiquitin ligases that localised to intestinal stem cells where they cooperate suppress signaling. Mutation these genes may be an alternate mechanism bypass signal. / double knockout mice develop germline has been...
Abstract Aim: Intratumoral genomic heterogeneity challenges personalized lung cancer care, especially where it relies upon small diagnostic samples. To explore representation provided by tumor subsampling, we performed whole genome sequencing (WGS) of multiple regions individual primary pulmonary adenocarcinomas (LUAC). Methods: An observational study was on three cases never-smoking LUAC resected with curative intent. Post-diagnostic residual fresh procured informed consent, along...
Ankylosing Spondylitis (AS) is a highly heritable inflammatory arthritis which occurs more frequently in men than women. In their recent publication examining sex differences the genetic aetiology of common complex traits and diseases, Bernabeu et al. (2021) observe heritability AS between sexes, genome-wide significant genotype by interaction risk at major histocompatability (MHC) locus 1 . The authors then present evidence suggesting that this arises primarily as result differential...