A5069505058- BRCA gene mutations in cancer
- Cancer Risks and Factors
- Nutritional Studies and Diet
- Nutrition, Genetics, and Disease
- Global Cancer Incidence and Screening
- Family Support in Illness
- Genetic factors in colorectal cancer
- Ovarian cancer diagnosis and treatment
- Childhood Cancer Survivors' Quality of Life
- Ethics in Clinical Research
- Cancer Genomics and Diagnostics
- Physical Activity and Health
- Cancer survivorship and care
- Genetic Associations and Epidemiology
- Genomics and Rare Diseases
- DNA Repair Mechanisms
- Patient-Provider Communication in Healthcare
- Breast Cancer Treatment Studies
- PARP inhibition in cancer therapy
- Estrogen and related hormone effects
- Obesity, Physical Activity, Diet
- Prenatal Screening and Diagnostics
- Genomic variations and chromosomal abnormalities
- Epigenetics and DNA Methylation
- Colorectal Cancer Screening and Detection
Fox Chase Cancer Center
2016-2025
University College Cork
2021-2023
University of Pennsylvania
2016-2021
Cork University Hospital
2005-2021
Royal Hospital for Women
2017-2020
Temple University Health System
2015-2020
American College of Medical Genetics
2018
American Academy of Pediatrics
2018
Pediatrics and Genetics
2018
Thomas Jefferson University
2017
Background: The finding of a decrease in contralateral breast cancer incidence following tamoxifen administration for adjuvant therapy led to the concept that drug might play role prevention. To test this hypothesis, National Surgical Adjuvant Breast and Bowel Project initiated Cancer Prevention Trial (P-1) 1992. Methods: Women (N = 13 388) at increased risk because they 1) were 60 years age or older, 2) 35–59 with 5-year predicted least 1.66%, 3) had history lobular carcinoma situ randomly...
PURPOSE In anticipation of the availability genetic testing for a breast-ovarian cancer susceptibility gene (BRCA1), this study examined interest in and expectations about impact potential test. PATIENTS AND METHODS The subjects were 121 first-degree relatives (FDRs) ovarian patients. design was cross-sectional. Subjects completed structured telephone interview attitudes testing, self-report psychologic questionnaires to assess coping style mood disturbance. RESULTS Overall, 75% FDRs said...
Studies have shown that a majority of women with family history breast cancer exaggerated perceptions their own risk this disease and experience excessive anxiety. In response to the need communicate more accurate information these women, specialized programs for counseling been initiated in medical centers across United States.Our purpose was 1) evaluate impact standardized protocol individualized on comprehension personal among first-degree relatives index patients 2) identify most least...
The NCCN Guidelines for Genetic/Familial High-Risk Assessment: Breast, Ovarian, and Pancreatic provide recommendations genetic testing counseling hereditary cancer syndromes, risk management patients who are diagnosed with syndromes associated an increased of these cancers. panel meets at least annually to review comments, examine relevant new data, reevaluate update recommendations. These Insights summarize the panel’s discussion most recent regarding criteria high-penetrance genes breast...
Journal Article Mammography Adherence and Psychological Distress Among Women at Risk for Breast Cancer Get access Caryn Lerman, Lerman Fox Chase CenterPhiladelphia, Pa Correspondence to: Ph.D., Center, 510 Township Line Rd., Cheltenham, PA 19012. Search other works by this author on: Oxford Academic PubMed Google Scholar Mary Daly, Daly Colleen Sands, Sands Andrew Balshem, Balshem Edward Lustbader, Lustbader Tracy Heggan, Heggan Lori Goldstein, Goldstein Joan James, James Paul Engstrom * See...
BACKGROUND As panel testing becomes more common in clinical practice, it is important to understand the prevalence and trends associated with pathogenic variants (PVs) identified. This especially true for genetically heterogeneous cancers, such as breast cancer (BC), which PVs different genes may be various risks subtypes. The authors evaluated outcomes of genetic among women who had a personal history BC. METHODS A total 35,409 single diagnosis BC underwent 25‐gene were included current...
The NCCN Guidelines for Genetic/Familial High-Risk Assessment: Breast, Ovarian, and Pancreatic focus primarily on assessment of pathogenic/likely pathogenic (P/LP) variants associated with increased risk breast, ovarian, pancreatic, prostate cancer, including BRCA1 , BRCA2 CDH1 PALB2 PTEN TP53 recommended approaches to genetic counseling/testing care strategies in individuals these P/LP variants. These Insights summarize important updates regarding: (1) a new section transgender, nonbinary...
The etiology of familial breast cancer is complex and involves genetic environmental factors such as hormonal lifestyle factors. Understanding aggregation a key to understanding the causes facilitating development effective prevention therapy. To address urgent research questions expedite translation results clinical setting, National Cancer Institute (USA) supported in 1995 establishment novel infrastructure, Breast Family Registry, collaboration six academic institutions their medical...
The authors examined predictors of psychological distress among women who were at increased risk for ovarian cancer. Participants 103 had least 1 first degree relative with Specifically, the tested relationship between dispositional attentional style monitoring (the tendency to scan threat-relevant information), perceptions cancer, intrusive thoughts regarding and distress. Overall, this sample exhibited moderately high levels High scores on associated perceived cancer elevated Finally,...
Background. This study evaluated the perceptions of patients with breast cancer their medical interactions providers. The determinants and psychological consequences communication problems also were examined. Methods. Ninety-seven Stage I or II completed a set validated questionnaires before initiating postoperative therapy. Data on distress collected at baseline 3-month follow-up, multivariate models fit to explain relationship between pretreatment subsequent distress. clinical variables...
The attitude of the public toward physicians and medical services is an issue current concern debate. To address this problem, instrument was developed using Thurstone scaling methods in conjunction with a Likert format modified scoring technique. Following pretesting among both patient population samples, survey conducted residents probability sample households city 200,000 people. questionnaire completed by 1,713 adults 1,112 households. Overall, attitudes were favorable professional...
A distinct morphologic and molecular phenotype has been reported for BRCA1-associated breast cancers; however, the of BRCA2-associated cancers is less certain. To comprehensively characterize we performed a retrospective case control study using tumors accrued through Breast Cancer Family Registry. We examined tumor morphology hormone receptor status in 157 hereditary with germline mutations BRCA2 314 negative BRCA1 that were matched age ethnicity. Tissue microarrays constructed from 64 185...
Men with BRCA2 mutations have been found to be at increased risk of developing prostate cancer. There is a recent report that carriers cancer poorer survival than noncarrier patients. In this study, we compared men mutation and BRCA1 We obtained the age diagnosis, death or current from 182 families 119 mutation. The median diagnosis was 4.0 years for vs 8.0 mutation, difference highly significant (P<0.01). It may important develop targeted chemotherapies treat in
Videoconferencing has been used to expand medical services low-access populations and could increase access genetic at community sites where in-person visits with providers are not available.To evaluate the feasibility of, patient feedback cognitive affective responses remote two-way videoconferencing (RVC) telegenetic multiple sociodemographically diverse practices without providers.Patients 3 in 2 US states outside host center completed RVC pretest (visit 1, V1) post-test 2, V2) counseling...
Genetic testing for cancer susceptibility genes is increasingly being integrated into medical care. Test results help inform risks of the individual tested as well family members who could benefit from knowing results. The responsibility informing relatives genetic test falls on proband, first member tested. However, there are several challenges associated with sharing within families including incomplete understanding results, emotional distance among members, and poor communication skills....
The debate about how to manage individual research results and incidental findings in genetic genomic has focused primarily on what information, if any, offer back participants. However, increasing controversy surrounds the question of whether researchers have any responsibility a participant’s (defined here include both findings) relatives, including after death. This arises multiple contexts, when discover result with potentially important health implications for relatives ask researcher...
Physical inactivity and sedentary behaviour are associated with higher breast cancer risk in observational studies, but ascribing causality is difficult. Mendelian randomisation (MR) assesses by simulating randomised trial groups using genotype. We assessed whether lifelong physical activity or time, genotype, may be causally overall, pre/post-menopause, case-groups defined tumour characteristics.
This longitudinal study examined predictors of mammography use among women with a family history breast cancer participating in risk assessment and surveillance program (N = 213). Assessed were background variables (age, prior utilization), cognitive (perceived vulnerability), affective (cancer worry general distress). Results logistic regression analyses predicting adherence 1 year after baseline contact, which utilization, feelings vulnerability, distress controlled for, indicated that age...