Lester J. Layfield

ORCID: 0000-0003-1344-6506
Publications
Citations
Views
---
Saved
---
About
Contact & Profiles
Research Areas
  • Sarcoma Diagnosis and Treatment
  • Salivary Gland Tumors Diagnosis and Treatment
  • Pancreatic and Hepatic Oncology Research
  • Lung Cancer Diagnosis and Treatment
  • Neuroendocrine Tumor Research Advances
  • Breast Lesions and Carcinomas
  • Breast Cancer Treatment Studies
  • Lung Cancer Treatments and Mutations
  • Oral and Maxillofacial Pathology
  • Bone Tumor Diagnosis and Treatments
  • Soft tissue tumor case studies
  • Cancer and Skin Lesions
  • Cervical Cancer and HPV Research
  • Medical Imaging and Pathology Studies
  • Head and Neck Anomalies
  • Thyroid Cancer Diagnosis and Treatment
  • Ear and Head Tumors
  • Urologic and reproductive health conditions
  • Gastrointestinal Tumor Research and Treatment
  • Musculoskeletal synovial abnormalities and treatments
  • Pancreatitis Pathology and Treatment
  • Neuroblastoma Research and Treatments
  • Head and Neck Cancer Studies
  • Cancer Diagnosis and Treatment
  • Tumors and Oncological Cases

University of Missouri
2016-2025

University of Missouri Health System
2019-2024

University of Missouri Hospital
2015-2023

International St. Mary's Hospital
2022

Catholic Kwandong University
2022

University of Alberta Hospital
2022

Alberta Hospital Edmonton
2022

The Ohio State University Wexner Medical Center
2022

University of Minnesota Rochester
2021

Philadelphia University
2021

10.1016/j.jasc.2015.03.003 article EN Journal of the American Society of Cytopathology 2015-05-01

On October 22 and 23, 2007, the National Cancer Institute (NCI) hosted The NCI Thyroid Fine Needle Aspiration (FNA) State of Science Conference, a two-day gathering in Bethesda, Maryland. Its mission was to establish comprehensive interdisciplinary informational dialogue dedicated thyroid FNA. Preparations for conference began 18 months earlier with designation steering committee, appointment nine working committees, coordination co-sponsoring organizations, establishment permanent web site....

10.1186/1742-6413-5-6 article EN CytoJournal 2008-01-01

The Papanicolaou Society of Cytopathology has developed a set guidelines for pancreatobiliary cytology including indications endoscopic ultrasound (EUS)‐guided fine needle aspiration (FNA) biopsy, techniques EUS‐FNA, terminology and nomenclature disease, ancillary testing, postbiopsy treatment management. All documents are based on the expertise authors, review literature, discussions draft document at several national international meetings over an 18‐month period synthesis online comments...

10.1002/dc.23092 article EN Diagnostic Cytopathology 2014-02-19

Recovery of pericolorectal lymph nodes from colectomy specimens has long been part colorectal cancer staging. Recently, adjuvant therapy added for high stage carcinomas, providing further impetus performing careful node dissections. Pericolorectal were examined to determine if there a change over time in the number recovered and proportion with pericolonic metastases carcinoma resection specimens. Also, authors attempted establish recommendation minimum that should be before colon can...

10.1093/ajcp/106.2.209 article EN American Journal of Clinical Pathology 1996-08-01

Smears obtained from 795 patients with suspicious thyroid nodules by fine needle aspiration (FNA) of the gland were seen over a 5-year period at UCLA Center for Health Sciences. From 72 who underwent subsequent surgical excision their nodules, inadequate or discrepant FNA diagnoses noticed in 20 cases (27.8%). These errors could be attributed to material diagnosis (n = 6), sampling 2), and cytodiagnostic 12). If follicular neoplasm was treated as indeterminate malignancy, overall efficiency...

10.1002/1097-0142(19890215)63:4<718::aid-cncr2820630420>3.0.co;2-n article EN Cancer 1989-02-15

Rhabdomyosarcoma (RMS), the most common soft tissue sarcoma of childhood, displays a variety histologic patterns. Immunohistochemistry is used extensively to distinguish RMS from its mimics. Myogenin and MyoD1, myogenic transcriptional regulatory proteins expressed early in skeletal muscle differentiation, are considered sensitive specific markers for more than desmin muscle-specific actin myoglobin. Previous studies have focused on expression myogenin MyoD1 small round cell tumors. This...

10.1097/00000478-200109000-00005 article EN The American Journal of Surgical Pathology 2001-09-01

A significant body of literature exists supporting the cost effectiveness fine-needle aspiration (FNA) cytology in work-up patients with potential neoplastic disease. Several authorities have stated that immediate, on-site smear evaluation by cytopathologists optimizes diagnostic accuracy and minimizes technique's insufficiency rate. This favorable effect on FNA is most pronounced for deep sites, where guided computed tomography (CT), ultrasound, bronchoscopy, or endoscopy. Little data exist...

10.1002/cncr.9046 article EN Cancer 2001-10-15

Adrenal pathology was examined in 41 autopsied patients with the acquired immune deficiency syndrome. This represents largest series and first study quantitation of adrenal cortical necrosis. In 32 cases clinical data were analyzed for features insufficiency. Common findings included vomiting, diarrhea, fever, hypotension, hyponatremia. None showed characteristic skin hyperpigmentation. Two suspected premortem to have one these patients, adrenocorticotrophic hormone (ACTH) stimulation...

10.1093/ajcp/84.5.594 article EN American Journal of Clinical Pathology 1985-11-01

A distinct morphologic and molecular phenotype has been reported for BRCA1-associated breast cancers; however, the of BRCA2-associated cancers is less certain. To comprehensively characterize we performed a retrospective case control study using tumors accrued through Breast Cancer Family Registry. We examined tumor morphology hormone receptor status in 157 hereditary with germline mutations BRCA2 314 negative BRCA1 that were matched age ethnicity. Tissue microarrays constructed from 64 185...

10.1097/01.pas.0000213351.49767.0f article EN The American Journal of Surgical Pathology 2006-12-19

Abstract National Cancer Institute State of the Science Conference on thyroid fine‐needle aspiration (FNA) summarized diagnostic terminology. Six categories were proposed including “follicular lesion undetermined significance” (FLUS). FLUS was defined as findings neither convincingly benign nor sufficiently atypical for a diagnosis neoplasm” or “suspicious malignancy.” It that this category represent less than 7% FNAs. A search cytology records at three University Hospitals performed term...

10.1002/dc.21093 article EN Diagnostic Cytopathology 2009-04-16

Echinoderm microtubule-associated proteinlike 4-anaplastic lymphoma kinase (EML4-ALK) gene fusions are detected in 3% to 13% of non-small cell lung carcinomas. Accurate testing for detection EML4-ALK is essential appropriate therapy selection.To compare reverse transcription-polymerase chain reaction (RT-PCR), immunohistochemistry (IHC), and fluorescence situ hybridization (FISH) methodologies fusions.Forty-six pulmonary adenocarcinomas were selected with enrichment wild-type epidermal...

10.5858/arpa.2011-0321-oa article EN Archives of Pathology & Laboratory Medicine 2012-06-28

Context.— The need for appropriate specimen use ancillary testing has become more commonplace in the practice of pathology. This, coupled with improvements technology, often provides less invasive methods testing, but presents new challenges to collection and handling these small specimens, including thoracic biopsy cytology samples. Objective.— To develop a clinical guideline recommendations on how obtain, handle, process tissue specimens diagnostic studies. Methods.— College American...

10.5858/arpa.2020-0119-cp article EN Archives of Pathology & Laboratory Medicine 2020-05-13
Coming Soon ...