Juan D. Cañete
A5005788294- Rheumatoid Arthritis Research and Therapies
- Spondyloarthritis Studies and Treatments
- Psoriasis: Treatment and Pathogenesis
- Autoimmune and Inflammatory Disorders Research
- Systemic Lupus Erythematosus Research
- Monoclonal and Polyclonal Antibodies Research
- Musculoskeletal synovial abnormalities and treatments
- Chronic Lymphocytic Leukemia Research
- Lymphoma Diagnosis and Treatment
- Inflammasome and immune disorders
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Cytokine Signaling Pathways and Interactions
- Systemic Sclerosis and Related Diseases
- Toxin Mechanisms and Immunotoxins
- Immunodeficiency and Autoimmune Disorders
- S100 Proteins and Annexins
- Biosimilars and Bioanalytical Methods
- Inflammatory Myopathies and Dermatomyositis
- Autoimmune Bullous Skin Diseases
- Bone and Joint Diseases
- Mast cells and histamine
- Health Systems, Economic Evaluations, Quality of Life
- Gout, Hyperuricemia, Uric Acid
- Metabolomics and Mass Spectrometry Studies
- T-cell and B-cell Immunology
Hospital Clínic de Barcelona
2016-2025
Consorci Institut D'Investigacions Biomediques August Pi I Sunyer
2016-2025
Fundació Clínic per a la Recerca Biomèdica
2023-2024
Center for Rheumatology
1999-2023
Hacettepe University
2023
Sociedad Española de Reumatología
2020-2022
Institut d'Investigacions Biomèdiques de Barcelona
2022
Universitat de Barcelona
2003-2021
Centro de Salud Casa del Barco
2021
Institute of Advanced Chemistry of Catalonia
2010-2019
Background Since the publication of European League Against Rheumatism recommendations for pharmacological treatment psoriatic arthritis (PsA) in 2012, new evidence and therapeutic agents have emerged. The objective was to update these recommendations. Methods A systematic literature review performed regarding PsA. Subsequently, were formulated based on expert opinion 34 Task Force members. Levels strengths allocated. Results updated comprise 5 overarching principles 10 recommendations,...
To update the European League Against Rheumatism (EULAR) recommendations for pharmacological treatment of psoriatic arthritis (PsA).According to EULAR standardised operating procedures, a systematic literature review was followed by consensus meeting develop this involving 28 international taskforce members in May 2019. Levels evidence and strengths were determined.The updated comprise 6 overarching principles 12 recommendations. The address nature PsA diversity both musculoskeletal...
Background Psoriatic arthritis (PsA) is a clinically heterogeneous disease. Clear consensual treatment guidance focused on the musculoskeletal manifestations of PsA would be advantageous. The authors present European League Against Rheumatism (EULAR) recommendations for with systemic or local (non-topical) symptomatic and disease-modifying antirheumatic drugs (DMARD). Methods are based evidence from systematic literature reviews performed non-steroidal anti-inflammatory (NSAID),...
<h3>Introduction</h3> The objective was to develop a questionnaire that can be used calculate score reflecting the impact of psoriatic arthritis (PsA) from patients' perspective: PsA Impact Disease (PsAID) questionnaire. <h3>Methods</h3> Twelve patient research partners identified important domains (areas health); 139 patients prioritised them according importance. Numeric rating scale (NRS) questions were developed, one for each domain. To combine into single score, relative weights...
Gut microbial dysbiosis is associated with the development of autoimmune disease, but mechanisms by which affects transition from asymptomatic autoimmunity to inflammatory disease are incompletely characterized. Here, we identify intestinal barrier integrity as an important checkpoint in translating inflammation. Zonulin family peptide (zonulin), a potent regulator for tight junctions, highly expressed mice and humans can be used predict arthritis. Increased serum zonulin levels accompanied...
Abstract Objective Studies comparing spondylarthritis (SpA) to rheumatoid arthritis (RA) synovitis suggest that innate immune cells may play a predominant role in the pathogenesis of SpA. Recent observations have indicated marked synovial mast cell infiltration psoriatic We therefore undertook present study investigate potential contribution inflammation Methods Synovial tissue and fluid were obtained from patients with either nonpsoriatic or SpA (n = 82) RA 50). biopsy was analyzed by...
BackgroundAlthough targeted biological treatments have transformed the outlook for patients with rheumatoid arthritis, 40% of show poor clinical response, which is mechanistically still unexplained. Because more than 50% arthritis low or absent CD20 B cells—the target rituximab—in main disease tissue (joint synovium), we hypothesised that, in these patients, IL-6 receptor inhibitor tocilizumab would be effective. The aim this trial was to compare effect rituximab who had an inadequate...
Patients with rheumatoid arthritis (RA) receive highly targeted biologic therapies without previous knowledge of target expression levels in the diseased tissue. Approximately 40% patients do not respond to individual and 5–20% are refractory all. In a biopsy-based, precision-medicine, randomized clinical trial RA (R4RA; n = 164), low/absent synovial B cell molecular signature had lower response rituximab (anti-CD20 monoclonal antibody) compared that tocilizumab (anti-IL6R although exact...
The aim of our study was to analyse the serum interleukin-6 (IL-6), tumour necrosis factor-alpha (TNF-alpha), interleukin-1 beta (IL-1 beta) and interferon-gamma (IFN-gamma) levels in patients with AS their relationship disease activity. An ELISA test used cytokine (IL-6, TNF-alpha, IL-1 IFN-gamma) 69 AS. Results were compared those from 43 RA 36 non-inflammatory back pain. between concentrations different cytokines parameters activity severity also evaluated. IL-6 TNF-alpha levels, but not...
Objective To examine the macroscopic vascular pattern of early synovitis in psoriatic arthritis (PsA), reactive (ReA), and rheumatoid (RA) to assess reliability grading features for synovitis. Methods Forty-four patients (14 PsA, 12 ReA, 18 RA) with knee who were undergoing arthroscopy assessed. Video recordings examination scored independently by 3 arthroscopists blinded patient's identity clinical details. Features vascularity, villous formation, pannus, granularity, capillary hyperemia...
Abstract At present only few biological data are available to indicate whether psoriatic arthritis (PsA) is part of the spondyloarthropathy (SpA) concept, it a separate disease entity or heterogeneous group with oligoarticular/axial forms belonging SpA and polyarticular resembling rheumatoid (RA). To address this issue regard peripheral synovitis, we compared synovial characteristics PsA those ankylosing spondylitis (AS)/undifferentiated (USpA) RA, synovium oligoarticular versus PsA....
Immune-mediated inflammatory diseases (IMIDs) are a group of complex and prevalent where disease diagnostic activity monitoring is highly challenging. The determination the metabolite profiles biological samples becoming powerful approach to identify new biomarkers clinical utility. In order diagnosis activity, we have performed first large-scale profiling urine metabolome six most IMIDs: rheumatoid arthritis, psoriatic psoriasis, systemic lupus erythematosus, Crohn's disease, ulcerative...
Abstract Background Accumulation of senescent cells has been associated with pro-inflammatory effects deleterious consequences in different human diseases. The purpose this study was to analyze cell senescence synovial tissues (ST), and its impact on the function fibroblasts (SF). Results expression marker p16INK4a (p16) analyzed by immunohistochemistry rheumatoid arthritis (RA), osteoarthritis (OA), normal ST from variably aged donors. proportion p16(+) older donors higher than younger...
To analyse the association between anti-carbamylated protein antibodies (Anti-CarP) and interstitial lung disease (ILD) in rheumatoid arthritis (RA) patients.Cross-sectional study including RA patients fulfilling 2010 ACR/EULAR criteria. The main population comprised two groups: (1) diagnosed with RA-ILD (RA-ILD group); (2) without ILD (non-ILD group). Non-ILD whom was suspected underwent a diagnostic work-up and, if diagnosed, were switched to group. by high-resolution computed tomography...
Objectives Eosinophils possess pro-inflammatory functions in asthma. However, our recent studies have suggested that innate lymphoid cells type 2 (ILC2s) and eosinophils proresolving properties rheumatoid arthritis (RA). Nothing is known yet about the mechanisms determining double-edged role of eosinophils. Therefore, we investigated whether asthma, a paradigm eosinophilic disease, can elicit resolution chronic arthritis. Methods Ovalbumin-triggered asthma was combined with K/BxN...
Despite highly effective targeted therapies for rheumatoid arthritis, about 40% of patients respond poorly, and predictive biomarkers treatment choices are lacking. We did a biopsy-driven trial to compare the response rituximab, etanercept, tocilizumab in biologic-naive with arthritis stratified synovial B cell status.