A5107975769- Systemic Lupus Erythematosus Research
- Gut microbiota and health
- Immune Cell Function and Interaction
- Neuroinflammation and Neurodegeneration Mechanisms
- Cancer, Stress, Anesthesia, and Immune Response
- Rheumatoid Arthritis Research and Therapies
- T-cell and B-cell Immunology
- Hepatitis C virus research
- Ubiquitin and proteasome pathways
- Barrier Structure and Function Studies
- Alcohol Consumption and Health Effects
- Atherosclerosis and Cardiovascular Diseases
- Monoclonal and Polyclonal Antibodies Research
- Adipokines, Inflammation, and Metabolic Diseases
- Dietary Effects on Health
- Endoplasmic Reticulum Stress and Disease
- Spondyloarthritis Studies and Treatments
- Immunotherapy and Immune Responses
- Trace Elements in Health
- Helicobacter pylori-related gastroenterology studies
- GDF15 and Related Biomarkers
- Chemokine receptors and signaling
- MicroRNA in disease regulation
- Cancer-related molecular mechanisms research
- Cytokine Signaling Pathways and Interactions
Universitätsklinikum Erlangen
2020-2024
Friedrich-Alexander-Universität Erlangen-Nürnberg
2020-2024
Princess Margaret Cancer Centre
2023-2024
University Health Network
2023-2024
Center for Rheumatology
2023
Institute of Rheumatology
2023
Chiba University
2023
University of Kansas
2014
Gut microbial dysbiosis is associated with the development of autoimmune disease, but mechanisms by which affects transition from asymptomatic autoimmunity to inflammatory disease are incompletely characterized. Here, we identify intestinal barrier integrity as an important checkpoint in translating inflammation. Zonulin family peptide (zonulin), a potent regulator for tight junctions, highly expressed mice and humans can be used predict arthritis. Increased serum zonulin levels accompanied...
Abstract Alcohol consumption is a consistent protective factor for the development of autoimmune diseases such as rheumatoid arthritis (RA). The underlying mechanism this tolerance-inducing effect alcohol, however, unknown. Here we show that alcohol and its metabolite acetate alter functional state T follicular helper (T FH ) cells in vitro vivo, thereby exerting immune regulatory properties. Alcohol-exposed mice have reduced Bcl6 PD-1 expression well IL-21 production by cells, preventing...
Lin28 is a family of RNA binding proteins and microRNA regulators. Two members this have been identified: Lin28A Lin28B, which are encoded by genes localized in different chromosomes but share high degree sequence identity. The role Lin28B androgen-independent prostate cancer (AIPC) not well understood. expressed all grades prostatic carcinomas cell lines, normal tissue. In study we found that co-localized the nucleus cytoplasm DU145 AIPC. expression protein positively correlated with c-Myc...
Rheumatoid arthritis (RA) is associated with an increased risk for cardiovascular events driven by abnormal platelet clotting effects. Platelets are produced megakaryocytes, deriving from megakaryocyte erythrocyte progenitors (MEP) in the bone marrow. Increased expansion across common autoimmune diseases was shown RA, systemic lupus erythematosus (SLE) and primary Sjögren’s syndrome (pSS). In this context, we evaluated role of microbial-derived short chain fatty acid (SCFA) propionate on...
Butyrophilins are surface receptors belonging to the immunoglobulin superfamily. While several members of butyrophilin family have been implicated in development unconventional T cells, 2a2 (Btn2a2) has shown inhibit conventional cell activation. Here, we demonstrate that steady state, primary source Btn2a2 thymic epithelial cells (TEC). Absence alters maturation and bypasses central tolerance mechanisms. Furthermore, Btn2a2-/- mice develop spontaneous autoimmunity resembling human Sjögren's...
Alcohol is among the most widely consumed dietary substances. Excessive alcohol consumption damages liver, heart, and brain. also has strong immunoregulatory properties. Here, we report how impairs T cell function via acetylation of cortactin, a protein that binds filamentous actin facilitates branching. Upon consumption, acetate, metabolite alcohol, accumulates in lymphoid organs. cells exposed to exhibit increased cortactin. Acetylation cortactin inhibits binding hence reduces migration,...
The study objective was to assess the role of CCL19
<h3>Background</h3> Intestinal dysbiosis has been associated with the development and progression of rheumatoid arthritis (RA) [<i>1].</i> Microbiota-derived metabolites such as short-chain fatty acids (SCFA) gained attention in research inflammatory diseases promising targets for new therapeutics. Previous work our lab showed potent preventive effect SCFA on onset (<i>2, 3</i>). Although effective potential therapeutic approaches are arising, their underlying mechanisms remain elusive...
<h3>Background:</h3> Chronic peripheral inflammation is well-documented for its ability to alter the activation of central nervous system (CNS) in diseases such as rheumatoid arthritis (RA) [1]. Furthermore, CNS able regulate inflammatory processes periphery [2]. However, environmental factors facilitating CNS-mediated suppression RA remain less explored. The intestinal microbiota produces immunomodulatory metabolites, including short-chain fatty acids (SCFA) [3], and neuroactive substances...
Abstract Chronic inflammatory diseases, like rheumatoid arthritis (RA) have been described to cause central nervous system (CNS) activation. Less is known about environmental factors that enable the CNS suppress peripheral inflammation in RA. Here, we identified gut microbiota-derived histamine as such factor. We show low levels of activate enteric system, increase inhibitory neurotransmitter concentrations spinal cord and restore homeostatic microglia, thereby reducing joints. Selective 3...
Background: While it is known that microbial dysbiosis associated with the onset of rheumatoid arthritis, mechanistic insights how facilitates development arthritis remained largely elusive to date. It especially interesting affects transition from asymptomatic autoimmunity arthritis. We speculated a breakdown intestinal barrier function caused by allows immune cells shuttle gut joints. Objectives: To test whether impaired before human RA and experimental seek for evidence migrate Methods:...
Background: Alcohol consumption has emerged as consistent protective factor for the development of autoimmune diseases such rheumatoid arthritis (RA). The underlying mechanism this tolerance-inducing effect alcohol, however, is unknown. Objectives: To understand anti-arthritogenic alcohol Methods: immune-regulatory properties in vivo were tested collagen-induced (CIA) and serum-induced (SIA) model well after immunization with T cell- dependent (NP-CGG) independent (TNP-FICOLL) antigens....
Summary Alcohol is among the most widely consumed dietary substances. Excessive alcohol consumption damages liver, heart and brain. also has strong immunoregulatory properties. Here we report how impairs T cell function via acetylation of cortactin, a protein that binds filamentous actin facilitates branching. Upon consumption, acetate, metabolite alcohol, accumulates in lymphoid organs. cells exposed to exhibit increased cortactin. Acetylation cortactin inhibits binding hence reduces...