A5035406666- Salivary Gland Disorders and Functions
- Head and Neck Cancer Studies
- Cancer Cells and Metastasis
- Cancer Genomics and Diagnostics
- Oral microbiology and periodontitis research
- Cancer-related molecular mechanisms research
- MicroRNA in disease regulation
- Oral Health Pathology and Treatment
- Salivary Gland Tumors Diagnosis and Treatment
- Endometriosis Research and Treatment
- Estrogen and related hormone effects
- Cleft Lip and Palate Research
- Extracellular vesicles in disease
- Cancer Immunotherapy and Biomarkers
- Reproductive System and Pregnancy
- Epigenetics and DNA Methylation
- RNA modifications and cancer
- Biosensors and Analytical Detection
- Glycosylation and Glycoproteins Research
- Galectins and Cancer Biology
- Peptidase Inhibition and Analysis
- Lung Cancer Treatments and Mutations
- Cancer-related gene regulation
- Advanced Proteomics Techniques and Applications
- Cancer Research and Treatments
Griffith University
2022-2025
Queensland University of Technology
2015-2025
Translational Research Institute
2015-2024
ORCID
2020
The University of Queensland
2011-2019
Graz University of Technology
2019
Princess Alexandra Hospital
2014
Institute of Bioengineering and Nanotechnology
2011-2013
Philips (Netherlands)
2007-2010
Maastricht University Medical Centre
2004-2010
Abstract Circulating tumor cells (CTCs) carry a wealth of information on primary and metastatic tumors critical for precise cancer detection, monitoring, treatment. Numerous microfluidic platforms have been developed in the past few years to capture these rare patient bloodstream deciphering needed. However, practical need high-quality method CTC isolation remains be met. Herein, we demonstrate novel multi-flow device that is able sensitively provide high purity (>87%) separation outcome...
Abstract Oral cancer (OC) is the most common form of head and neck cancer. Despite high incidence unfavourable patient outcomes, currently, there are no biomarkers for early detection OC. This study aims to discover, develop, validate a novel saliva-based microRNA signature diagnosis prediction OC risk in oral potentially malignant disorders (OPMD). The Cancer Genome Atlas (TCGA) miRNA sequencing data small RNA saliva samples were used discover differentially expressed miRNAs. Identified...
Understanding and predicting individual responses to common stressors is essential for optimising performance in high-stress environments. This article outlines a protocol study identify biomarkers that predict under heat, musculoskeletal, psychosocial sleep stress, future integration into wearable sensor system. In Phase I, healthy adults aged between 18 45 years (n=104) will be recruited an intervention trial involves exposure one of the four stressors: or deprivation. Biomarkers...
Owing to its ease of collection, saliva is potentially the sample choice in diagnosis. Salivary biomolecules have provided a porthole surveying person's health and well-being. Our study aims were (1) demonstrate effects pre-analytical steps, collection pre-processing techniques on salivary protein detection (2) establish an indication reference intervals for 3 clinical interest.Saliva samples collected from participants (n = 25, ages 20-35 years) using following methods: no stimulation...
Abstract Saliva has attracted attention as a diagnostic fluid due to the association of oral microbiota with systemic diseases. However, lack standardised methods for saliva collection led slow uptake in microbiome research. The aim this study was systematically evaluate potential effects on salivary profiles using different collection, storage and gDNA extraction. Three types fractions were collected from healthy individuals or without stabilising buffer. Subsequently, three extraction...
The oral microbiome can play a role in the instigation and progression of diseases that manifest into other systemic conditions. These associations encourage exploration dysbiosis leading to pathogenesis cancers. In this study, rinse was used characterize fluctuation associated with cavity cancer (OCC) oropharyngeal cancers (OPC). study cohort consists normal healthy controls (n = 10, between 20 30 years age; n above 50 age), high-risk individuals 11, age bad hygiene and/or diseases) OCC OPC...
Abstract Tumor biopsy is the gold standard for assessment of clinical biomarkers treatment. However, tumors change dynamically in response to therapy, and there remains a need more representative biomarker that can be assayed over course Circulating tumor cells (CTCs) may provide clinically important comprehensive tumoral information predictive treatment outcome. Blood samples were processed CTCs from 56 patients using ClearCell FX system. Captured phenotyped CTC clusters markers...
Circulating tumour cells (CTCs) are the metastatic precursors to distant disease in head and neck cancers (HNCs). Whilst prognostic predictive value of single CTCs have been well documented, role CTC clusters, which potentially a higher capacity limited. In this study, authors used novel straight microfluidic chip focus capture CTCs. The offers high cell recoveries with clinically relevant numbers (10⁻500 cells/mL) without need for further purification. Single were identified 10/21 patient...
Estradiol (E(2)) is an important promoter of the growth both eutopic and ectopic endometrium. The findings with regard to expression activity steroidogenic enzymes in endometrium controls, endometriosis patients endometriotic lesions are not consistent.In this study, we have looked at mRNA protein levels a range [aromatase, 17beta-hydroxysteroid dehydrogenases (17beta-HSD) type 1, 2 4, estrogen sulfotransferase (EST) steroid sulfatase (STS)] (n = 14) deep-infiltrative as well disease-free...
Objective : It has been suggested that adiponectin regulates plasma free fatty acid (FFA) clearance by stimulating FFA uptake and/or oxidation in muscle. We aimed to determine changes concentration and receptor 1 2 mRNA expression skeletal muscle during after prolonged exercise under normal, fasting conditions (high trial; HFA) following pharmacological inhibition of adipose tissue lipolysis (low LFA). Furthermore, we detect locate tissue. Methods Ten subjects performed two trials (120 min...
Head and neck squamous cell carcinoma (HNSCC) accounts for a bulk of the oral laryngeal cancers, majority (70%) which are associated with smoking excessive drinking, major known risk factors development HNSCC. In contrast to reports that suggest an inverse relationship between global DNA CpG methylation, hypermethylation promoters number genes was detected in saliva collected from patients Using sensitive methylation-specific polymerase chain reaction (MSP) assay determine specific...