A5072438559- Adipose Tissue and Metabolism
- Diet and metabolism studies
- Muscle metabolism and nutrition
- Cannabis and Cannabinoid Research
- Adipokines, Inflammation, and Metabolic Diseases
- Birth, Development, and Health
- Diet, Metabolism, and Disease
- Fatty Acid Research and Health
- Pancreatic function and diabetes
- Exercise and Physiological Responses
- Cardiovascular and exercise physiology
- Metabolism, Diabetes, and Cancer
- Regulation of Appetite and Obesity
- Dietary Effects on Health
- Diabetes Treatment and Management
- Nutritional Studies and Diet
- Ovarian function and disorders
- Receptor Mechanisms and Signaling
- Biochemical effects in animals
- Muscle Physiology and Disorders
- Sports Performance and Training
- Phytochemicals and Antioxidant Activities
- Liver Disease Diagnosis and Treatment
- Reproductive Biology and Fertility
- Eating Disorders and Behaviors
Victoria University
2016-2025
Australian Institute for Musculoskeletal Science
2016-2025
Western Health
2022
Victoria School of Management
2010-2021
The University of Melbourne
1999-2016
Institute of Food Science & Technology
2016
Canberra (United Kingdom)
2015
ACT Government
2015
Florey Institute of Neuroscience and Mental Health
2015
The University of Texas at El Paso
2015
Adiponectin is an adipocyte-derived hormone associated with antidiabetic actions. In rodent skeletal muscle, globular adiponectin (gAD) activates AMP-kinase (AMPK) and stimulates fatty acid oxidation effects mediated through the receptors, AdipoR1 AdipoR2. present study, we examined mRNA expression of receptors gAD on AMPK activity in muscle myotubes from lean, obese, obese type 2 diabetic subjects. Myotubes all groups expressed approximately 4.5-fold more than AdipoR2, subjects tended to...
Objective : It has been suggested that adiponectin regulates plasma free fatty acid (FFA) clearance by stimulating FFA uptake and/or oxidation in muscle. We aimed to determine changes concentration and receptor 1 2 mRNA expression skeletal muscle during after prolonged exercise under normal, fasting conditions (high trial; HFA) following pharmacological inhibition of adipose tissue lipolysis (low LFA). Furthermore, we detect locate tissue. Methods Ten subjects performed two trials (120 min...
Abstract Context: Leptin is thought to regulate whole-body adiposity and insulin sensitivity, at least in part, by stimulating fatty acid metabolism via activation of AMP-kinase (AMPK) skeletal muscle. Human obesity associated with leptin resistance, recent studies have demonstrated that hypothalamic expression the suppressors cytokine signaling 3 (SOCS3) regulates sensitivity rodents. Objective: The objective study was investigate effects on oxidation AMPK primary myotubes derived from lean...
Endocannabinoids and their G-protein coupled receptors (GPCR) are a current research focus in the area of obesity due to system's role food intake glucose lipid metabolism. Importantly, overweight obese individuals often have higher circulating levels arachidonic acid-derived endocannabinoids anandamide (AEA) 2-arachidonoyl glycerol (2-AG) an altered pattern receptor expression. Consequently, this leads increase orexigenic stimuli, changes fatty acid synthesis, insulin sensitivity,...
The cannabinoid receptor 2 (CB2) is well known for its immune modulatory role. However, recent localisation of CB2 receptors in metabolically active tissue suggests that the plays a significant role energy homeostasis. This study was designed to investigate impact chronic stimulation on food intake, body weight and mood. Lean male C57BL/6 mice were injected i.p. with selective agonist, JWH-015 (0.0, 1.0, 5.0 10.0 mg kg-1) establish dose response parameters. Mice made obese following exposure...
Background/Aims: GPR43 and GPR120 have recently been deorphanised as receptors for fatty acids. Fatty acids mediate a variety of metabolic processes in the body, however, effect these on metabolism is not fully understood. Here, we characterise diet-induced obesity expression tissues important maintaining health. Methods: Six-week old male Sprague Dawley rats were fed either high fat diet (HFD; 22% fat) or control (5% fat; n = 8-9/group) 12 weeks. Rats euthanized heart, liver, soleus...
Type 2 diabetes (T2D) is metabolic disorder associated with a decrease in insulin activity and/or secretion from the β-cells of pancreas, leading to elevated circulating glucose. Current management practices for T2D are complex varying long-term effectiveness. Agonism G protein-coupled receptor GPR119 has received lot recent interest as potential therapeutic.
Linoleic acid (LA), an n-6 polyunsaturated fatty (PUFA), is essential for fetal growth and development. A maternal high LA (HLA) diet alters cardiovascular development in adolescent rats hepatic function adult a sex-specific manner. We investigated the effects of HLA on offspring lipids lipid metabolism gene expression, ability postnatal to alter these effects. Female Wistar Kyoto were fed low (LLA; 1.44% energy from LA) or (HLA; 6.21% diets during pregnancy gestation/lactation. Offspring,...
Endogenous endocannabinoids bind to cannabinoid receptors; namely CB1, CB2, TRPV1 and GPR55, activate intracellular pathways that control many cellular functions. Elevated levels of have been identified in diseases such as obesity diabetes, with the onset diabetic nephropathy associated proximal tubule hypertrophy. Recent research has a role for CB1 apoptosis human tubular (HK2) cells, however other receptors not investigated. We investigated if played hypertrophy HK2 cells. Characterisation...
Background: Acute exercise reduces postprandial oxidative stress and glycemia; however, the effects of intensity are unclear. We investigated effect acute low-volume high-intensity interval-exercise (LV-HIIE) continuous moderate-intensity (CMIE) on glycemic control in overweight obese, inactive adults. Methods: Twenty-seven adults were randomly allocated to perform a single session LV-HIIE (9 females, 5 males; age: 30 ± 1 years; BMI: 29 kg·m-2; mean SEM) or CMIE (8 2.0; 2.0) h after...
Abstract STUDY QUESTION Does 12 weeks of high-intensity interval training (HIIT) result in greater improvements cardio-metabolic and reproductive outcomes compared to standard moderate-intensity continuous (MICT) women with polycystic ovary syndrome (PCOS)? SUMMARY ANSWER HIIT offers aerobic capacity, insulin sensitivity menstrual cyclicity, larger reductions hyperandrogenism MICT. WHAT IS KNOWN ALREADY Exercise is recognized improve clinical PCOS, but little known about whether results...