A5010879671- Wound Healing and Treatments
- Burn Injury Management and Outcomes
- Periodontal Regeneration and Treatments
- Exercise and Physiological Responses
- Metabolomics and Mass Spectrometry Studies
- Sports injuries and prevention
- Diabetic Foot Ulcer Assessment and Management
- Forensic Entomology and Diptera Studies
- Electrospun Nanofibers in Biomedical Applications
- Muscle metabolism and nutrition
- Extracellular vesicles in disease
- Tissue Engineering and Regenerative Medicine
- Nitric Oxide and Endothelin Effects
- Peripheral Artery Disease Management
- Diagnosis and Treatment of Venous Diseases
- Adipose Tissue and Metabolism
- Cardiovascular Effects of Exercise
- Mesenchymal stem cell research
- Bone Tissue Engineering Materials
- Trauma, Hemostasis, Coagulopathy, Resuscitation
- Trauma and Emergency Care Studies
- Dental Implant Techniques and Outcomes
- Advanced Sensor and Energy Harvesting Materials
- MicroRNA in disease regulation
- Interprofessional Education and Collaboration
Queensland University of Technology
2016-2025
Rutherford Appleton Laboratory
2020-2024
University of Liverpool
2014-2019
National Institute of Biomedical Innovation, Health and Nutrition
2015
Brisbane School of Theology
2015
Understanding and predicting individual responses to common stressors is essential for optimising performance in high-stress environments. This article outlines a protocol study identify biomarkers that predict under heat, musculoskeletal, psychosocial sleep stress, future integration into wearable sensor system. In Phase I, healthy adults aged between 18 45 years (n=104) will be recruited an intervention trial involves exposure one of the four stressors: or deprivation. Biomarkers...
Objective There is a paucity of research on patients presenting with uninfected diabetic foot ulcers (DFU) that go to develop infection. We aimed investigate the incidence and risk factors for developing infection in large regional cohort DFUs. Methods performed secondary analysis data collected from validated prospective state-wide clinical database Queensland (Australia). Patients their first visit an DFU Diabetic Foot Service one thirteen regions between January 2012 December 2013 were...
Aging is associated with a vasoconstrictive, pro-coagulant, and pro-inflammatory profile of arteries decline in the bioavailability endothelium-derived molecule nitric oxide. Dietary nitrate elicits vasodilatory, anti-coagulant anti-inflammatory effects younger individuals, but little known about whether these benefits are evident older adults. We investigated 140 mL nitrate-rich (HI-NI; containing 12.9 mmol nitrate) versus nitrate-depleted beetroot juice (LO-NI; ≤0.04 on blood pressure,...
Contusion injuries in skeletal muscle commonly occur contact sport and vehicular industrial workplace accidents. Icing has traditionally been used to treat such under the premise that it alleviates pain, reduces tissue metabolism, modifies vascular responses decrease swelling. Previous research examined effects of icing on inflammation microcirculatory dynamics following injury. However, whether influences angiogenesis, collateral vessel growth, or myofiber regeneration remains unknown. We...
Extracellular vesicles (EVs) are mammalian cell-derived nano-scale structures enclosed by a lipid bilayer that were previously considered to be cell debris with little biological value. However, EVs now recognized possess function, acting as packaging, transport and delivery mechanisms which functional molecules (i.e., miRNAs) can transferred target cells over some distance. To examine the miRNA from keratinocyte-derived EVs, we isolated three distinct populations of both HaCaT primary human...
ABSTRACT Saliva is a child appropriate biofluid, but it has not previously been used to evaluate the systemic response burn injury in children. The aim of this study was investigate salivary proteome children with small area thermal skin burns relative different characteristics (mechanism, time re‐epithelialization and risk emotional distress). SWATH Mass Spectrometry quantify abundance 742 proteins saliva ( n = 22) healthy controls 37). Eight were differentially abundant compared children,...
The discovery of protein variation is an important strategy in disease diagnosis within the biological sciences. current benchmark for elucidating information from multiple variables so called "omics" disciplines Such variability uncovered by implementation multivariable data mining techniques which come under two primary categories, machine learning strategies and statistical based approaches. Typically proteomic studies can produce hundreds or thousands variables, p, per observation, n,...
Epidermal homeostasis is maintained through the balance between keratinocyte proliferation, differentiation and desquamation; however, human skin equivalent (HSE) models are known to differentiate excessively. In native tissue, proteases such as kallikrein-related peptidase (KLK) 5 KLK7 cleave extracellular components of corneodesmosomes; proteins corneodesmosin, desmocollin 1 desmoglein 1, loosening cellular connections enabling desquamation. The actions tightly controlled by protease...
Abstract Background Growing evidence suggests that the pluripotent state of mesenchymal stem cells (MSCs) relies on specific local microenvironmental cues such as adhesion molecules and growth factors. Fibronectin (FN), fibroblast factor 2 (FGF2), bone morphogenetic protein 4 (BMP4) are key players in regulation stemness lineage commitment MSCs. Therefore, this study was designed to investigate pluripotency multilineage differentiation marrow-derived MSCs (BMSCs) with introduction FN, FGF-2,...
Abstract Ca 2+ -transcription coupling controls gene expression patterns that define vascular smooth muscle cell (VSMC) phenotype. Although not well understood this allows normally contractile VSMCs to become proliferative following vessel injury, a process essential for repair but which also contributes remodelling, atherogenesis and restenosis. Here we show the /HCO 3 − -sensitive enzyme, soluble adenylyl cyclase (sAC), links influx in human coronary artery cells (hCASMCs) 3′,5′-cyclic...
Epidermogenesis and epidermal wound healing are tightly regulated processes during which keratinocytes must migrate, proliferate differentiate. Cell-to-cell adhesion is crucial to the initiation regulation of these processes. CUB-domain-containing protein (CDCP)1 a transmembrane glycoprotein that differentially tyrosine phosphorylated changes in cell survival signalling, expressed by native human skin, as well primary cultures.To investigate expression CDCP1 epidermogenesis its role...
Disconnection of a cell from its epithelial neighbours and the formation mesenchymal phenotype are associated with profound changes in distribution cellular components new polarity. We observed dramatic redistribution inositol trisphosphate receptors (IP3Rs) stromal interaction molecule 1 (STIM1)-competent endoplasmic reticulum-plasma membrane junctions (ER-PM junctions) when pancreatic ductal adenocarcinoma (PDAC) cells disconnect their undergo individual migration. In monolayers IP3Rs...
Biomarker analysis has been implemented in sports research an attempt to monitor the effects of exertion and fatigue athletes. This study proposed that while such biomarkers may be useful for monitoring injury risk workers, proteomic approaches might also utilised identify novel or markers. We found urinary urea cortisol levels were significantly elevated mining workers following a 12 hour overnight shift. These failed return baseline over 24 h more active maintenance crew compared truck...
Abstract Negative pressure wound therapy has been used to promote healing in a variety of settings, including as an adjunct silver‐impregnated dressings the acute management paediatric burns. Fluid aspirated by negative system represents potentially insightful research matrix for understanding burn microenvironment and intervention's biochemical mechanisms action. The aim this study was characterize proteome fluid collected using from children with small‐area thermal Samples were obtained...
The interface between synthetic percutaneous devices and skin is a common area for bacterial infection, which may ultimately result in failure of the device. Better integration with help reduce infection rates due to creation dermal seal. However, mismatch material chemical properties presents challenge closing gap at skin-device interface. Here, we have used tissue engineering approach by creating highly fibrous poly(ε-caprolactone) scaffold using melt electrowriting seeding this...