A5032713493- Cardiovascular and exercise physiology
- Nitric Oxide and Endothelin Effects
- Muscle metabolism and nutrition
- Exercise and Physiological Responses
- Cardiovascular Health and Disease Prevention
- Cardiovascular Function and Risk Factors
- High Altitude and Hypoxia
- Pharmacological Effects and Assays
- Peripheral Artery Disease Management
- Sports Performance and Training
- Blood Pressure and Hypertension Studies
- Adipose Tissue and Metabolism
- Renal function and acid-base balance
- Adipokines, Inflammation, and Metabolic Diseases
- Nutritional Studies and Diet
- Obesity, Physical Activity, Diet
- Medical and Biological Ozone Research
- Dietary Effects on Health
- Muscle and Compartmental Disorders
- Gout, Hyperuricemia, Uric Acid
- Diet and metabolism studies
- Heart Failure Treatment and Management
- Hydrogen's biological and therapeutic effects
- Sodium Intake and Health
- Eating Disorders and Behaviors
University of Virginia
2017-2024
Karolinska Institutet
2024
Victoria University
2017-2023
Heavitree Hospital
2016
University of Exeter
2016
Aging is associated with a vasoconstrictive, pro-coagulant, and pro-inflammatory profile of arteries decline in the bioavailability endothelium-derived molecule nitric oxide. Dietary nitrate elicits vasodilatory, anti-coagulant anti-inflammatory effects younger individuals, but little known about whether these benefits are evident older adults. We investigated 140 mL nitrate-rich (HI-NI; containing 12.9 mmol nitrate) versus nitrate-depleted beetroot juice (LO-NI; ≤0.04 on blood pressure,...
Although inorganic nitrate (NO 3 − ) supplementation has increased in popularity as a means of improving exercise performance, data females at different phases the menstrual cycle are lacking despite known interactions estrogen with NO. This study revealed neither NO nor influenced economy or vascular health healthy young naturally menstruating females, while significantly worsened endurance capacity (10%) independent phase.
Dietary nitrate (NO
Chronic underperfusion of the skeletal muscle tissues is a contributor to decrease in exercise capacity patients with heart failure reduced ejection fraction (HFrEF). This due, at least part, impaired nitric oxide (NO) bioavailability. Oral inorganic nitrate supplementation increases NO bioavailability and may be used improve capacity, vascular function, mitochondrial respiration. Sixteen HFrEF (fifteen men, 63 ± 4 yr, body mass index: 31.8 2.1 kg/m2) participated randomized, double-blind,...
Abstract Skeletal muscle may act as a reservoir for N‐oxides following inorganic nitrate supplementation. This idea is most intriguing in individuals with peripheral artery disease (PAD) who are unable to endogenously upregulate nitric oxide. study analyzed plasma and skeletal nitrite concentrations along exercise performance, prior 12‐weeks of training combined oral supplementation (EX+BR) or placebo (EX+PL) participants PAD. Non‐supplemented, at baseline, there were no differences nitrate....
This study compared exercise-induced changes in flow-mediated dilation after acute moderate- and high-intensity exercise females postmenopause supplementing either inorganic nitrate (beetroot juice) or placebo. BRJ improved peak ΔFMD postexercise, + HIE increased FMD measured as over time. Neither PL MIE nor FMD. These findings suggest that supplementation combined with may benefit vascular health PM.
Recent data have suggested that inorganic nitrate ([Formula: see text]) supplementation may benefit males, however, females experience worsened endurance capacity independent of menstrual cycle phase. This study revealed neither [Formula: text] nor the follicular phase influenced maximal isometric voluntary contraction or in healthy, young, naturally menstruating females, whereas significantly estimated peak power (Pmax) and velocity (Vmax)
Inorganic nitrate (NO
Ghrelin circulates in acylated (AG) and deacylated (DAG) forms, which are known to have independent effects on glucose regulation, vascular health, appetite. While acute exercise has been shown affect ghrelin levels, data the impact of intensity AG DAG is sparse primarily limited males. PURPOSE: To investigate effect sex levels untrained humans. METHODS: Four males (age: 44.5 ± 6.0y; BMI: 22.3 0.61; VO2peak: 37.7 5.8 mL/kg/min) six females 41.2 6.0 y; 24.7 5.5 kg/m2; 25.7 5.0 completed a...
Inorganic nitrate (NO3-) can be reduced to nitrite via the entero-salivary pathway and then nitric oxide in oxygen states such as exercise. Oral NO3- supplementation improves tissue oxygenation during exercise, however, sex-dependent responses are lacking. PURPOSE: To examine effect of on moderate- (MOD) severe-intensity (SEV) exercise young adults. METHODS: Cycle ergometry was performed determine gas exchange threshold (GET) VO2peak. In a randomized, double-blind crossover study, 12 females...
INTRODUCTION: Flow-mediated dilation (FMD) and nitric oxide (NO) bioavailability are impaired in post-menopausal females (PMF) due to loss of endogenous estrogen. Although exercise training improves FMD older males, equivocal data exists PMF, with most studies employing moderate rather than high intensity (MIE/HIE). HIE induces more arterial shear stress increases NO MIE. Inorganic nitrate (NO3-) supplementation also tolerance as well FMD. Combined NO3- or MIE may provide the beneficial...
Advancing age is associated with changes in arterial structure and function that contribute to increased blood pressure, pulse pressure cardiovascular disease risk. Exercise training beneficially moderates these risks. Peripheral Remodeling through Intermittent Muscular (PRIME) a novel approach, involving peripheral focused low-mass high-repetition exercises imposes low cardiorespiratory strain. Initiation of structured exercise PRIME, rather than aerobic (AT) yields superior benefits...
Patients with chronic heart failure (HF) are characterized by exercise intolerance. Maximal oxygen consumption (VO2peak) is predictive of health outcomes, but often influenced early onset fatigue or external factors. Oxygen at the ventilatory threshold (VO2AT) a submaximal marker sustainable uptake and has been shown to predict 6 month mortality in HF. An intervention that increases VO2AT HF would likely produce beneficial clinical quality life outcomes. Nitric oxide (NO) bioavailability...
Exercise intolerance is the primary cause of morbidity and decreased quality life in patients with chronic heart failure (HF). The strong prognostic value exercise capacity HF warrants identification interventions which maximize this population. Although etiology complex, reduced nitric oxide (NO) bioavailability an underlying characteristic that has been shown to moderate physiological processes related including vascular function, tissue perfusion, mitochondrial function contractile...