A5037115291- Adipose Tissue and Metabolism
- Mitochondrial Function and Pathology
- Muscle metabolism and nutrition
- Cardiovascular and exercise physiology
- Sleep and related disorders
- Muscle Physiology and Disorders
- Sports Performance and Training
- Chemotherapy-induced cardiotoxicity and mitigation
- Diet and metabolism studies
- Circadian rhythm and melatonin
- Cardiovascular Effects of Exercise
- Sleep and Wakefulness Research
- Exercise and Physiological Responses
- Cancer survivorship and care
- Childhood Cancer Survivors' Quality of Life
- Genetics and Physical Performance
- ATP Synthase and ATPases Research
- Dietary Effects on Health
- Physical Activity and Health
- Cardiac electrophysiology and arrhythmias
- Nitric Oxide and Endothelin Effects
- Thermoregulation and physiological responses
- Metabolism and Genetic Disorders
- Pluripotent Stem Cells Research
- Metabolism, Diabetes, and Cancer
Victoria University
2017-2024
Baker Heart and Diabetes Institute
2020-2024
American College of Surgeons
2018
University of Tasmania
2016
Sleep restriction has previously been associated with the loss of muscle mass in both human and animal models. The rate myofibrillar protein synthesis (MyoPS) is a key variable regulating skeletal can be increased by performing high-intensity interval exercise (HIIE), although effect sleep on MyoPS unknown. In present study, we demonstrate that participants undergoing protocol (five nights, 4 h bed each night) had lower rates MyoPS; however, were maintained at control levels HIIE during this...
Sleep loss has emerged as a risk factor for the development of impaired glucose tolerance. The mechanisms underpinning this observation are unknown; however, both mitochondrial dysfunction and circadian misalignment have been proposed. Because exercise improves tolerance function, alters rhythms, we investigated whether may counteract effects induced by inadequate sleep. To minimize between-group differences baseline characteristics, 24 healthy young males were allocated into one three...
Background Exercise elicits a range of adaptive responses in skeletal muscle, which include changes mRNA expression. To better understand the health benefits exercise training, it is important to investigate underlying molecular mechanisms muscle adaptation exercise. However, most studies have assessed events at only few time-points within short time frame post-exercise, and variations gene expression kinetics not been addressed systematically. Methods We 23 isoforms implicated response six...
Abstract Mitochondria are dynamic organelles, intricately designed to meet cellular energy requirements. To accommodate alterations in demand, mitochondria have a high degree of plasticity, changing response transient activation numerous stress‐related pathways. This adaptive is particularly relevant highly metabolic tissues such as skeletal muscle, where support biological processes related metabolism, growth and regeneration. Aerobic exercise potent stimulus for muscle remodelling, leading...
Abstract Endurance exercise begun with reduced muscle glycogen stores seems to potentiate skeletal protein abundance and gene expression. However, it is unknown whether this greater signaling responses due performing two sessions in close proximity—as a first session necessary reduce the stores. In present study, we manipulated recovery duration between glycogen‐depleting second session, such that started both approaches but was performed either 2 or 15 hours after (so‐called “twice‐a‐day”...
Assessments of mitochondrial respiration and content are common in skeletal muscle research exercise science. However, many sources technical biological variation render these analyses susceptible to error. This study aimed better quantify the reliability different experimental designs and/or techniques so as assist researchers obtain more reliable data.We examined repeatability maximal oxidative phosphorylation permeabilized fibres via high-resolution respirometry, citrate synthase activity...
BACKGROUND: Allogeneic stem cell transplantation (allo-SCT) is an efficacious treatment for hematologic malignancies but can be complicated by cardiac dysfunction and exercise intolerance impacting quality of life longevity. We conducted a randomized controlled trial testing whether multicomponent activity intervention could attenuate reductions in cardiorespiratory fitness function (co-primary end points) adults undergoing allo-SCT. METHODS: Sixty-two scheduled allo-SCT were to 4-month...
Chronic underperfusion of the skeletal muscle tissues is a contributor to decrease in exercise capacity patients with heart failure reduced ejection fraction (HFrEF). This due, at least part, impaired nitric oxide (NO) bioavailability. Oral inorganic nitrate supplementation increases NO bioavailability and may be used improve capacity, vascular function, mitochondrial respiration. Sixteen HFrEF (fifteen men, 63 ± 4 yr, body mass index: 31.8 2.1 kg/m2) participated randomized, double-blind,...
Multiple pluripotent cell populations, which together comprise the lineage, have been identified. The mechanisms that control progression between these populations are still poorly understood. formation of early primitive ectoderm-like (EPL) cells from mouse embryonic stem (mES) provides a model to understand how one such transition is regulated. EPL form mES in response l-proline uptake through transporter Slc38a2. Using inhibitors signaling we shown Src family kinases, p38 MAPK, ERK1/2 and...
Background Inadequate sleep is associated with many detrimental health effects, including increased risk of developing insulin resistance and type 2 diabetes. These effects have been changes to the skeletal muscle transcriptome, although this has not characterised in response a period restriction. Exercise induces beneficial transcriptional within that may counteract some negative We hypothesised restriction would down-regulate pathways glucose metabolism, but performing exercise mitigate...
Mood state and alertness are negatively affected by sleep loss, can be positively influenced exercise. However, the potential mitigating effects of exercise on sleep-loss-induced changes in mood have not been studied comprehensively. Twenty-four healthy young males were matched into one three, 5-night interventions: normal (NS; total time (TST) per night = 449 ± 22 min), restriction (SR; TST 230 5 or (SR + EX; 235 min, plus three sessions high-intensity interval (HIIE)). was assessed using...
Abstract Aerobic and resistance exercise (RE) induce distinct molecular responses. One hypothesis is that these responses are antagonistic unfavorable for the anabolic response to RE when concurrent performed. This thesis may also depend on participants' training status order. We measured free‐living myofibrillar protein synthesis (MyoPS) rates associated resistance‐only (with different orders), before after training. Moderately active men completed one of three interventions (matched age,...
ABSTRACT Aim Exercise elicits a range of adaptive responses in skeletal muscle that include changes mRNA expression. To better understand the health benefits exercise training, it is essential to investigate underlying molecular mechanisms adaptations exercise. However, most studies have assessed events at few convenient time points within short frame post exercise, and variations gene expression kinetics not been addressed systematically. Method Muscle biopsies were collected from nine...
Coronavirus disease-19 (COVID-19) has been associated with cardiac pathology raising the possibility of serious arrhythmias among athletes returning to competition post infection.1–3 Several studies have assessed function and structure in post-COVID-19 infection but challenged by selection bias, lack an appropriate control group none included comprehensive imaging, exercise testing, clinical electrophysiology.2,4–7 We recruited every player from a squad professional basketballers involved...
Allogeneic stem cell transplantation (allo-SCT) is a potentially lifesaving treatment for high-risk hematological malignancy, but survivors experience markedly elevated rates of cardiovascular disease and associated functional impairment. Mounting evidence suggests regular exercise, combined with reduction in sedentary time through replacement light exercise may be useful therapeutic strategy the prevention comorbidities. However, this type intervention has yet to evaluated patients...
The aim of this study was to investigate the relationship between mitochondrial content and respiratory function whole-body insulin resistance in high-fat diet (HFD) fed rats. Male Wistar rats were given either a chow or an HFD for 12 weeks. After 4 weeks dietary intervention, half each group began 8 interval training. In vivo glucose tolerance assessed. Mitochondrial assessed permeabilised soleus white gastrocnemius (WG) muscles. determined by measurement citrate synthase (CS) activity...
Abstract Introduction Both sleep loss and exercise regulate gene expression in skeletal muscle, yet little is known about how the interaction of these stressors affects transcriptome. The aim this study was to investigate effect nine nights restriction, with repeated resistance (REx) sessions, on muscle transcriptome young, trained females. Methods Ten healthy females aged 18-35 years undertook a randomised cross-over nights’ restriction (SR; 5-h time bed) normal (NS; ≥7 h minimum 6-week...