A5014368664- Adipose Tissue and Metabolism
- Mitochondrial Function and Pathology
- Cardiovascular and exercise physiology
- Muscle metabolism and nutrition
- Sports Performance and Training
- Autophagy in Disease and Therapy
- Sports injuries and prevention
- ATP Synthase and ATPases Research
- Extracellular vesicles in disease
- Exercise and Physiological Responses
- Diet and metabolism studies
- Heart Rate Variability and Autonomic Control
- Genetics and Physical Performance
- Alzheimer's disease research and treatments
- Muscle Physiology and Disorders
- Streptococcal Infections and Treatments
- Nuclear Receptors and Signaling
- Mesenchymal stem cell research
- Amyloidosis: Diagnosis, Treatment, Outcomes
- Endoplasmic Reticulum Stress and Disease
- Coffee research and impacts
- Genetic Syndromes and Imprinting
- Muscle activation and electromyography studies
- Shoulder Injury and Treatment
- Dementia and Cognitive Impairment Research
Victoria University
2018-2024
Deakin University
2022-2024
University of Lausanne
2024
University Hospital of Lausanne
2024
Victoria School of Management
2022
The University of Melbourne
2022
Universitat de Miguel Hernández d'Elx
2016-2017
Research Institute for Olympic Sports
2016
University of Jyväskylä
2016
Hospital Universitari i Politècnic La Fe
2015
Background To determine the validity of lactate threshold (LT) and maximal oxygen uptake () determined during graded exercise test (GXT) different durations using LT calculations. Trained male cyclists (n = 17) completed five GXTs varying stage length (1, 3, 4, 7 10 min) to establish LT, a series 30-min constant power bouts steady state (MLSS). was assessed each GXT subsequent verification exhaustive bout (VEB), 14 LTs were calculated from four (3, min)—yielding total 56 LTs. Agreement...
Measures of HR variability (HRV) have shown potential to be use in training prescription.The aim this study was investigate the effectiveness using HRV endurance prescription.Forty recreational runners were divided into HRV-guided experimental group (EXP) and traditional predefined (TRAD). After a 4-wk preparation period, TRAD trained according program including two three moderate- (MOD) high-intensity (HIT) sessions per week during an 8-wk intensive period. The timing MOD HIT EXP based on...
Abstract Mitochondrial defects are implicated in multiple diseases and aging. Exercise training is an accessible, inexpensive therapeutic intervention that can improve mitochondrial bioenergetics quality of life. By combining omics techniques with biochemical silico normalisation, we removed the bias arising from training-induced increase content to unearth intricate previously undemonstrated network differentially prioritised adaptations. We show changes hundreds transcripts, proteins,...
To investigate the influence of adding a weekly eccentric-overload training (EOT) session in several athletic performance's tests, 18 team-handball players were assigned either to an EOT (n = 11) or Control 7) group. Both groups continued perform same habitual strength training, but group added one session/week during 7-week programme consisting four sets eight repetitions for bilateral half-squat and unilateral lunge exercises. The test battery included handball throwing velocity, maximum...
Abstract Analyses of mitochondrial adaptations in human skeletal muscle have mostly used whole-muscle samples, where results may be confounded by the presence a mixture type I and II fibres. Using our adapted mass spectrometry-based proteomics workflow, we provide insights into fibre-specific differences men before after training. Our findings challenge previous conclusions regarding extent fibre-type-specific remodelling proteome suggest that most baseline protein abundances between fibre...
Since the pioneering work of Professor John Holloszy, it has been known that exercise training can increase total protein content mitochondria in skeletal muscle (Holloszy, 1967). This seminal inspired others to investigate effects different volumes and intensities on mitochondrial biogenesis using a range techniques (as reviewed Granata et al. 2018a). The 'gold standard' method for assessing is transmission electron microscopy (TEM), which be used calculate volume density (MitoVD) or...
Mitochondria are the cellular organelles responsible for resynthesising majority of ATP. In skeletal muscle, there is an increased ATP turnover during resistance exercise to sustain energetic demands muscle contraction. Despite this, little known regarding mitochondrial characteristics chronically strength-trained individuals and any potential pathways regulating strength-specific remodelling. Here, we investigated structural in strength athletes age-matched untrained controls. The pool was...
Abstract Aim To investigate how delayed post‐exercise carbohydrate intake affects muscle glycogen, metabolic‐ and mitochondrial‐related molecular responses, subsequent high‐intensity interval exercise (HIIE) capacity. Methods In a double‐blind cross‐over design, nine recreationally active men performed HIIE (10 × 2‐min cycling, ~94% W˙ peak ) in the fed state, on two occasions. During 0–3 h post‐HIIE, participants drank either carbohydrates (“Immediate Carbohydrate” [IC], providing 2.4 g/kg)...
Purpose To compare the effect of 4-week unknown vs known loads strength training intervention on power output performance and throwing velocity in junior team handball players. Methods Twenty-eight team-handball players (17.2 ± 0.6 years, 1.79 0.07 m, 75.6 9.4 kg)were divided into two groups (unknown loads: UL; KL). Both performed sessions weekly consisting four sets six repetitions bench press throw exercise, using 30%, 50% 70% subjects’ individual 1 repetition maximum (1RM). In each set,...
Assessments of mitochondrial respiration and content are common in skeletal muscle research exercise science. However, many sources technical biological variation render these analyses susceptible to error. This study aimed better quantify the reliability different experimental designs and/or techniques so as assist researchers obtain more reliable data.We examined repeatability maximal oxidative phosphorylation permeabilized fibres via high-resolution respirometry, citrate synthase activity...
Abstract There are epidemiological associations between obesity and type 2 diabetes, cardiovascular disease Alzheimer’s disease. The role of amyloid beta 42 (Aβ ) in these diverse chronic diseases is obscure. Here we show that adipose tissue releases Aβ , which increased from male mice with associated higher plasma . Increasing circulating levels without has no effect on systemic glucose homeostasis but obesity-like effects the heart, including reduced cardiac clearance impaired function....
Autophagy is a key intracellular mechanism by which cells degrade old or dysfunctional proteins and organelles. In skeletal muscle, evidence suggests that exercise increases autophagosome content autophagy flux. However, the exercise-induced response seems to differ between rodents humans, little known about how different prescription parameters may affect these results. The present study utilised muscle samples obtained from four experimental studies using rats humans. Here, we show that,...
Abstract Autophagy is a cellular process by which proteins and organelles are degraded inside the lysosome. Exercise known to influence regulation of autophagy in skeletal muscle. However, as gold standard techniques assess flux vivo restricted animal research, important gaps remain our understanding how exercise influences activity humans. Using available datasets, we show gene expression profile receptors ATG8 family members differ between human mouse muscle, providing potential...
To compare the effects of a standardized endurance-training program with individualized endurance training modified based on cumulative load provided by Polar training-load feature.After 12 wk similar training, 24 recreationally endurance-trained men were matched to training-load-guided (TL, n = 10) or (ST, 14) group and continued for wk. In TL, sessions individually chosen daily an estimated load, whereas in ST was 4-6 sessions/wk. Endurance performance (shortest 1000-m running time during...
Background Inadequate sleep is associated with many detrimental health effects, including increased risk of developing insulin resistance and type 2 diabetes. These effects have been changes to the skeletal muscle transcriptome, although this has not characterised in response a period restriction. Exercise induces beneficial transcriptional within that may counteract some negative We hypothesised restriction would down-regulate pathways glucose metabolism, but performing exercise mitigate...
As the knowledge base and importance of mitochondrial physiology to human health expands, necessity for harmonizing terminologyconcerning respiratory states rates has become increasingly apparent. Thechemiosmotic theoryestablishes mechanism energy transformationandcoupling in oxidative phosphorylation. Theunifying concept protonmotive force providestheframeworkfordeveloping a consistent theoretical foundation ofmitochondrial bioenergetics.We followguidelines International Union Pure Applied...