A5048526787- Antibiotics Pharmacokinetics and Efficacy
- Nosocomial Infections in ICU
- Antibiotic Resistance in Bacteria
- Pneumonia and Respiratory Infections
- Antibiotic Use and Resistance
- Influenza Virus Research Studies
- Sepsis Diagnosis and Treatment
- Mechanical Circulatory Support Devices
- Immune Response and Inflammation
- Respiratory viral infections research
- Intensive Care Unit Cognitive Disorders
- HIV Research and Treatment
- Antifungal resistance and susceptibility
- Educational Games and Gamification
- Antimicrobial Resistance in Staphylococcus
- HIV/AIDS Research and Interventions
- Bacterial Identification and Susceptibility Testing
- Electrolyte and hormonal disorders
- Cardiac Structural Anomalies and Repair
- Renal function and acid-base balance
- Liver Disease and Transplantation
- Acute Kidney Injury Research
- Fungal Infections and Studies
- Infective Endocarditis Diagnosis and Management
- Bacterial biofilms and quorum sensing
Hospital Universitari i Politècnic La Fe
2014-2024
Leitat Technological Center
2015-2018
Instituto de Investigación Sanitaria La Fe
2017
Universitat de Barcelona
2016
Consorci Institut D'Investigacions Biomediques August Pi I Sunyer
2016
Centro de Investigación Biomédica en Red de Enfermedades Respiratorias
2016
Walden University
2016
Instituto Politécnico Nacional
2013-2015
Royal Liverpool University Hospital
2012
University of Liverpool
2012
Human host immune response following infection with the new variant of A/H1N1 pandemic influenza virus (nvH1N1) is poorly understood. We utilize here systemic cytokine and antibody levels in evaluating differences early both mild severe patients infected nvH1N1.We profiled 29 cytokines chemokines evaluated haemagglutination inhibition activity as quantitative qualitative measurements responses serum obtained during first five days after symptoms onset, two cohorts nvH1N1 patients. Severe...
Pandemic A/H1N1/2009 influenza causes severe lower respiratory complications in rare cases. The association between host immune responses and clinical outcome cases is unknown.We utilized gene expression, cytokine profiles generation of antibody following hospitalization 19 critically ill patients with primary pandemic pneumonia for identifying associated outcome. Ingenuity pathway analysis 8.5 (IPA) (Ingenuity Systems, Redwood City, CA) was used to select, annotate visualize genes by...
Bacterial infection has always accompanied human beings, causing suffering and death while also contributing to the advancement of medical science. However, treatment infections become more complex in recent times. The increasing resistance bacterial strains antibiotics diminished effectiveness therapeutic arsenal, making it less likely find appropriate empiric antibiotic option. Additionally, development persistence biofilms have prevalent, attributed greater use invasive devices that...
The objective of this study was to evaluate the impact empirical therapy with fluconazole or an echinocandin on 30- and 90-day mortality in critically ill patients candidemia. outcome whom deescalated also assessed.Retrospective, observational multicenter study.Medical surgical ICUs nine Spanish hospitals.Adult (≥ 18 yr) episode Candida bloodstream infection during ICU admission from January 2011 April 2016.Patient characteristics, infection-related variables, therapeutic interventions,...
Introduction In previous work it has been shown that when a spotted platyfish ( Platy-poecilus maculatus ) is mated with Mexican swordtail Xiphophorus hellerii melanosis develops in all those hybrids which inherit the spotting factor from their parent. When parent homozygous for SpSp ), hybrids; whereas if heterozygous Spsp one-half of are melanotic and other half normal. The two types melanophores—one type, smaller, called micromelanophores, inherited as an autosomal dominant, large...
The aim of this study is to evaluate the risk factors for colonisation by multidrug resistant (MDR) K. pneumoniae in a critical care unit and relationship between antibiotic pressure exerted antimicrobial treatments received patients. A prospective observational was designed. Patients admitted more than 48 h an intensive were included. Samples surveillance cultures obtained from all patients upon admission once week. association MDR determined logistic regression. Cox regression model used...
Several authors have demonstrated the relationship between voriconazole concentrations and risk of therapeutic failure adverse events However, information about in critically ill patient is scarce. The aim this study was to analyse plasma pharmacokinetic behaviour patients their association with treatment response development toxicity.A prospective, observational conducted. Patients admitted an intensive care unit on intravenous were included. Plasma measured days 4 7 from start treatment....
Journal Article Disinfection: II. The Manner of Death Of Certain Bacteria and Yeasts when Subjected to Mild Chemical Physical Agents Get access Georges Knaysi, Knaysi Ithaca, N. Y. Search for other works by this author on: Oxford Academic PubMed Google Scholar Morris Gordon Infectious Diseases, Volume 47, Issue 4, October 1930, Pages 303–317, https://doi.org/10.1093/infdis/47.4.303 Published: 01 1930 history Received: 26 March
The Amplicor HIV-1 Monitor test was compared to the nucleic acid sequence-based amplification (Nasba) assay system for quantitation of human immunodeficiency virus (HIV) RNA in three different types clinical samples: plasma, serum, and plasma subjected freeze-and-thaw cycles. Each detected HIV same 73 (90%) 81 samples tested, quantitative results obtained with two assays were significantly correlated. Both higher levels patients CD4+ cell counts lower than 200 cells/mm3 cells/mm3. In...
Abstract Background Severe disease caused by 2009 pandemic influenza A/H1N1virus is characterized the presence of hypercytokinemia. The origin exacerbated cytokine response unclear. As observed previously, uncontrolled virus replication could strongly influence production. objective present study was to evaluate relationship between host responses and viral levels in critically ill patients. Methods Twenty three patients admitted ICU with primary pneumonia were included this study. A...
Ventilator-associated pneumonia (VAP) can have a clear onset or may be result of the gradual appearance symptoms and signs VAP (gradual VAP). The aim this paper is to describe development process with intention discriminating between those pneumonias beginning that are diagnosed after period maturation. In addition, we evaluate effect starting time antibiotic treatment in both situations.Consecutive ventilated patients fulfilling criteria were included. monitored for clinical,...
Abstract Introduction External ventricular drainage (EVD)-related ventriculitis is one of the most severe complications associated with use EVDs. Establishing an early and certain diagnosis can be difficult in critically ill patients. We performed this prospective study to evaluate usefulness soluble triggering receptor expressed on myeloid cells-1 (sTREM-1) determination cerebrospinal fluid (CSF) ventriculitis. Methods A observational was conducted 73 consecutive patients EVD. Samples CSF...
In this study, we evaluate the effect of extracorporeal membrane oxygenation (ECMO) and ventricular assist devices (Levitronix) on pharmacokinetic amikacin in critically ill patients. Twelve patients with ECMO three Levitronix who started treatment were included. Amikacin pre (Cmax) post (Cmin) dose serum concentrations measured during first 72–96 hours initiation. Pharmacokinetic parameters performed by Bayesian adjustment. The median initial was 1,000 mg (range: 600–1,400 mg). Mean plasma...