A5036220332- Antibiotic Resistance in Bacteria
- Antibiotics Pharmacokinetics and Efficacy
- Bacterial Identification and Susceptibility Testing
- Antibiotic Use and Resistance
- Antifungal resistance and susceptibility
- Pneumonia and Respiratory Infections
- Antimicrobial Resistance in Staphylococcus
- Cystic Fibrosis Research Advances
- Bacterial biofilms and quorum sensing
- Fungal Infections and Studies
- Enterobacteriaceae and Cronobacter Research
- Pharmaceutical and Antibiotic Environmental Impacts
- Infections and bacterial resistance
- Helicobacter pylori-related gastroenterology studies
- Urinary Tract Infections Management
- Vibrio bacteria research studies
- Mycobacterium research and diagnosis
- Nosocomial Infections in ICU
- Streptococcal Infections and Treatments
- SARS-CoV-2 and COVID-19 Research
- Infective Endocarditis Diagnosis and Management
- Escherichia coli research studies
- Nail Diseases and Treatments
- Plant Pathogens and Fungal Diseases
- Bacterial Infections and Vaccines
Instituto Ramón y Cajal de Investigación Sanitaria
2016-2025
Hospital Universitario Ramón y Cajal
2016-2025
Instituto de Salud Carlos III
2016-2025
Centro de Investigación Biomédica en Red
2009-2025
Red Espanola de Investigacion en Patologia Infecciosa
2015-2024
Instituto Cajal
2013-2024
Centro de Investigación Biomédica en Red de Enfermedades Respiratorias
2021-2024
Hospital General Universitario Gregorio Marañón
2021-2024
Centre for Biomedical Network Research on Rare Diseases
2018-2024
Oregon Medical Research Center
2023
Bronchiectasis in adults is a chronic disorder associated with poor quality of life and frequent exacerbations many patients. There have been no previous international guidelines.The European Respiratory Society guidelines for the management adult bronchiectasis describe appropriate investigation treatment strategies determined by systematic review literature.A multidisciplinary group representing respiratory medicine, microbiology, physiotherapy, thoracic surgery, primary care, methodology...
CTX-M β-lactamases are considered a paradigm in the evolution of resistance mechanism. Incorporation different chromosomal blaCTX-M related genes from species Kluyvera has derived clusters. In silico analyses have shown that this event occurred at least nine times; CTX-M-1 cluster (3), CTX-M-2 and CTX-M-9 clusters (2 each), CTX-M-8 CTX-M-25 (1 each). This been mainly produced by participation genetic mobilization units such as insertion sequences (ISEcp1 or ISCR1) later incorporation...
Bacterial infections are very common and represent one of the most important reasons progression liver failure, development liver-related complications, mortality in patients with cirrhosis. In fact, bacterial may be a triggering factor for occurrence gastrointestinal bleeding, hypervolemic hyponatremia, hepatic encephalopathy, kidney acute-on-chronic failure. Moreover, cause repeated hospitalizations, impaired health-related quality life, increased healthcare costs develop as consequence...
Extended-spectrum beta-lactamases (ESBLs) have been increasingly reported in Europe since their first description 1983. During the 1990s, they were described mainly as members of TEM- and SHV-beta-lactamase families Klebsiella pneumoniae causing nosocomial outbreaks. Nowadays, are mostly found Escherichia coli that cause community-acquired infections with increasing frequency contain CTX-M enzymes. Dissemination specific clones or clonal groups epidemic plasmids community settings has main...
Abstract We analyzed 43 CTX-M-15–producing Escherichia coli isolates and 6 plasmids encoding the blaCTX-M-15 gene from Canada, India, Kuwait, France, Switzerland, Portugal, Spain. Most belonged to phylogroups B2 (50%) D (25%). An EC-B2 strain of clonal complex sequence type (ST) 131 was detected in all countries; other corresponded ST28, ST405, ST354, ST695 specific areas. EC-D strains were clonally unrelated but 3 countries ST405. All CTX-M-15 IncFII group with overrepresentation...
To evaluate the prevalence of extended-spectrum beta-lactamase (ESBL)-producing strains among species Enterobacteriaceae, a microdilution susceptibility test was performed with Klebsiella pneumoniae, Escherichia coli, Proteus mirabilis, and Salmonella that were isolated as part SENTRY project. The highest percentage ESBL phenotype (defined minimum inhibitory concentration [MIC] > or =2 microg/mL for ceftazidime, ceftriaxone, aztreonam) detected K. pneumoniae from Latin America (45%),...
<h3>Background</h3> Extended-spectrum β-lactamase (ESBL)-producing<i>Escherichia coli</i>is an increasingly important group of community pathogens worldwide. These organisms are frequently resistant to many the antimicrobial agents usually recommended for treatment infections caused by<i>E coli</i>, such as penicillins, cephalosporins, fluoroquinolones, and trimethoprim-sulfamethoxazole. Data concerning risk factors, clinical features, therapeutic options scarce. <h3>Methods</h3> A...
Human host immune response following infection with the new variant of A/H1N1 pandemic influenza virus (nvH1N1) is poorly understood. We utilize here systemic cytokine and antibody levels in evaluating differences early both mild severe patients infected nvH1N1.We profiled 29 cytokines chemokines evaluated haemagglutination inhibition activity as quantitative qualitative measurements responses serum obtained during first five days after symptoms onset, two cohorts nvH1N1 patients. Severe...
ABSTRACT A multilocus sequence typing (MLST) scheme based on seven housekeeping genes was used to investigate the epidemiology and population structure of Enterococcus faecalis . MLST 110 isolates from different sources geographic locations revealed 55 types that grouped into four major clonal complexes (CC2, CC9, CC10, CC21) by use eBURST. Two these complexes, CC2 are particularly fit in hospital environment, as includes previously described BVE complex identified an alternative CC9...
The emergence and global spread of carbapenemase-producing Enterobacteriaceae is great concern to health services worldwide. These bacteria are often resistant all beta-lactam antibiotics frequently co-resistant most other antibiotics, leaving very few treatment options. epidemiology compounded by the diversity carbapenem-hydrolysing enzymes ability their genes between different bacterial species. Difficulties also encountered laboratories when trying detect carbapenemase production during...
Over recent decades, several publications have described optimization procedures for antibiotic therapy in the individual patient based on antimicrobial MIC values. Most methods include therapeutic drug monitoring and use a single determination plus relevant pharmacokinetics/pharmacodynamics to adjust dose optimize exposure antibacterial effects. However, of an obtained by is inappropriate. First, routine clinical laboratories cannot determine MICs with sufficient accuracy guide dosage owing...