Sílvia Gómez-Zorrilla
A5018232762- Antibiotic Resistance in Bacteria
- Antibiotics Pharmacokinetics and Efficacy
- Antibiotic Use and Resistance
- COVID-19 Clinical Research Studies
- Urinary Tract Infections Management
- Bacterial biofilms and quorum sensing
- Pneumonia and Respiratory Infections
- SARS-CoV-2 and COVID-19 Research
- Long-Term Effects of COVID-19
- Bacterial Identification and Susceptibility Testing
- Antimicrobial Resistance in Staphylococcus
- Sepsis Diagnosis and Treatment
- Nosocomial Infections in ICU
- Streptococcal Infections and Treatments
- Drug-Induced Adverse Reactions
- Pharmaceutical and Antibiotic Environmental Impacts
- COVID-19 and healthcare impacts
- Pharmaceutical studies and practices
- COVID-19 diagnosis using AI
- Machine Learning in Healthcare
- Fungal Infections and Studies
- Trace Elements in Health
- Dermatology and Skin Diseases
- Pneumocystis jirovecii pneumonia detection and treatment
- Vibrio bacteria research studies
Hospital Del Mar
2021-2025
Universitat Autònoma de Barcelona
2020-2025
Universitat Pompeu Fabra
2019-2025
Centro de Investigación Biomédica en Red
2022-2025
Instituto de Salud Carlos III
2020-2025
Hospital del Mar Research Institute
2019-2023
Red Espanola de Investigacion en Patologia Infecciosa
2019-2022
Centre for Biomedical Network Research on Rare Diseases
2022
Parc de Salut
2021
Municipal Institute for Medical Research
2021
Using a large multicenter prospective cohort of Pseudomonas aeruginosa bacteremia, we demonstrate that the exoU type III secretion system genotype is independently associated with increased risk early mortality bloodstream infections, whereas late multidrug-resistant profiles. Background. The (TTSS) major virulence determinant aeruginosa. objective this study was to determine whether TTSS useful prognostic marker P. bacteremia mortality. We also studied potential association between...
This study assessed the molecular epidemiology, resistance mechanisms, and susceptibility profiles of a collection 150 extensively drug-resistant (XDR) Pseudomonas aeruginosa clinical isolates obtained from 2015 Spanish multicenter study, with particular focus on resistome analysis in relation to ceftolozane-tazobactam susceptibility. Broth microdilution MICs revealed that nearly all (>95%) were nonsusceptible piperacillin-tazobactam, ceftazidime, cefepime, aztreonam, imipenem, meropenem,...
Zinc is an essential micronutrient that impacts host-pathogen interplay at infection. balances immune responses, and also has a proven direct antiviral action against some viruses. Importantly, zinc deficiency (ZD) common condition in elderly individuals with chronic diseases, two groups increased risk for severe coronavirus disease 2019 (COVID-19) outcomes. We hypothesize serum content (SZC) influences COVID-19 progression, thus might represent useful biomarker.
Abstract Objectives To investigate pharmacokinetics (PK) and safety (primary objectives) efficacy (secondary objective) of the investigational monobactam/β-lactamase inhibitor combination aztreonam/avibactam in patients with complicated intra-abdominal infection (cIAI). Methods This Phase 2a open-label, multicentre study (NCT02655419; EudraCT 2015-002726-39) enrolled adults cIAI into sequential cohorts for 5–14 days treatment. Cohort 1 received an loading dose 500/137 mg (30 min infusion),...
Background: The first wave of COVID-19 pandemic may have significantly impacted antimicrobial consumption in hospitals. objective this study was to assess the evolution during period. Methods: A retrospective quasi-experimental before–after conducted a Spanish tertiary care hospital. compared two periods: pre-pandemic, from January 2018 February 2020, and March June 2020. Antimicrobial analyzed monthly as defined daily doses (DDD)/100 bed-days overall hospital ICU were evaluated. Results: An...
ABSTRACT The potential role of Pseudomonas aeruginosa (PA) intestinal colonization in the subsequent development infections has not been thoroughly investigated. aims this study were to assess PA as a predictor and investigate risk factors associated with infection patients intensive care unit (ICU). For purpose, prospective was conducted that included (i) active surveillance rectal at ICU admission weekly until discharge, (ii) detection clinical infections, (iii) genotypic analysis by...
ABSTRACT The intestinal reservoir is central to the epidemiology of Pseudomonas aeruginosa , but dynamics colonization by different phenotypes have been poorly described. To determine impact antimicrobial exposure on multidrug-resistant (MDR) and extensively drug-resistant (XDR) P. we screened intensive care unit (ICU) patients for rectal admission at weekly intervals. During an 18-month study period, 414 ICU were enrolled, whom 179 (43%) colonized; 112 (63%) these identified 67 (37%) during...
There is little information about the efficacy of active alternative drugs to carbapenems except β-lactam/β-lactamase inhibitors for treatment bloodstream infections (BSIs) due extended-spectrum β-lactamase–producing Enterobacteriaceae (ESBL-E). The objective this study was assess outcomes patients with BSI ESBL-E who received empiric therapy such (other [OADs]) or carbapenems. A multinational retrospective cohort OADs performed. Cox regression including a propensity score receiving...
Abstract Background Acute skin and soft tissue infections (ASSTIs) represent a common reason for attending emergency department (ED) hospitalization. We investigate characteristics of cohort ASSTIs-patients comparing patients managed with hospitalization versus outpatients. Methods Retrospective study all consecutive adults who consulted to an ED due ASSTIs. Setting: Hospital del Mar (Barcelona, Spain). Period: January 2018–December 2020. Sample size (320) was calculated detect 10%...
Abstract Background/Objectives To assess the microbiological and clinical features of Klebsiella pneumoniae healthcare-associated bacteraemia urinary origin (HCA-BUO) in Spain, with a particular focus on third generation cephalosporin-(3GCR-Kp) carbapenem-resistant (CR-Kp) isolates. Methods A total 96 (21.4%, 96/449) K. blood isolates were prospectively collected from patients HCA-BUO (n=443) 12 tertiary-care hospitals Spain (2017-2019). Antimicrobial susceptibility was determined (standard...
OBJECTIVE: To describe a case of levetiracetam-induced drug reaction with eosinophilia and systemic symptoms (DRESS) syndrome. CASE SUMMARY: A 31-year-old white male low-grade astrocytoma presenting tonic-clonic seizures was treated levetiracetam 1 g twice daily dexamethasone (initial dosage 12 mg/day, tapered down to 2 mg/day). On day 45 after initiation, discontinued continued. The patient developed fever dyspnea on 46 admitted the hospital 49. chest X-ray showed bilateral pulmonary...
CD4/CD8 ratio has been used as a quantitative prognostic risk factor in patients with viral infections. This study aims to assess the association between in-hospital mortality and at admission among individuals acute SARS-CoV-2 infection.This is longitudinal cohort data of all consecutive admitted COVID-19 unit Hospital del Mar, Barcelona, Spain for ≥48 h March May 2020. The CD4+ CD8+ T-cell subset differentiation was assessed by flow cytometry well complete blood test. Patients were...
Treatment failure occurs in about 25% of patients with methicillin-susceptible Staphylococcus aureus (MSSA) bacteremia. We assessed whether cloxacillin plus fosfomycin achieves better treatment success than alone hospitalized adults MSSA conducted a multicenter, open-label, phase III-IV superiority randomized clinical trial. randomly assigned (1:1) to receive 2 g intravenous every 4 h or 3 6 for the initial 7 days. The primary endpoint was at day 7, composite following criteria: patient...
To compare results of amoxicillin/clavulanate susceptibility testing using CLSI and EUCAST methodologies to evaluate their impact on outcome in patients with bacteraemia caused by Enterobacteriaceae.A prospective observational cohort study was conducted 13 Spanish hospitals. Patients due Enterobacteriaceae who received empirical intravenous treatment for at least 48 h were included. MICs determined following recommendations. Outcome variables were: failure the end (FEAMC); day 21; 30...
More data are needed about the safety of antibiotic de-escalation in specific clinical situations as a strategy to reduce exposure broad-spectrum antibiotics. The aims this study were investigate predictors and its impact on outcome patients with bloodstream infection due Enterobacteriaceae (BSI-E).A post hoc analysis was performed prospective, multicenter cohort BSI-E initially treated ertapenem or antipseudomonal β-lactams. Logistic regression used analyze factors associated early (EDE)...
Abstract Objectives To assess the microbiological characteristics of Escherichia coli causing healthcare-associated bacteraemia urinary origin (HCA-BUO) in Spain (ITUBRAS-2 project), with particular focus on ESBL producers and isolates belonging to ST131 high-risk clone (HiRC). Clinical outcomes associated infection were investigated. Methods A total 222 E. blood prospectively collected from patients HCA-BUO 12 tertiary-care hospitals (2017–19). Antimicrobial susceptibility...