A5081460840- Antimicrobial Resistance in Staphylococcus
- Antibiotic Resistance in Bacteria
- Bacterial Identification and Susceptibility Testing
- Pneumonia and Respiratory Infections
- Bacterial biofilms and quorum sensing
- Streptococcal Infections and Treatments
- Infective Endocarditis Diagnosis and Management
- Antibiotics Pharmacokinetics and Efficacy
- Antibiotic Use and Resistance
- Nosocomial Infections in ICU
- Antifungal resistance and susceptibility
- Pneumocystis jirovecii pneumonia detection and treatment
- Advanced Radiotherapy Techniques
- Central Venous Catheters and Hemodialysis
- Vibrio bacteria research studies
- Urinary Tract Infections Management
- Bacterial Infections and Vaccines
- Clostridium difficile and Clostridium perfringens research
- Neutropenia and Cancer Infections
- COVID-19 Clinical Research Studies
- Mycobacterium research and diagnosis
- Enterobacteriaceae and Cronobacter Research
- SARS-CoV-2 and COVID-19 Research
- Microscopic Colitis
- Lung Cancer Diagnosis and Treatment
Institut d'Investigació Biomédica de Bellvitge
2016-2025
Universitat de Barcelona
2016-2025
Instituto de Salud Carlos III
2016-2025
Centro de Investigación Biomédica en Red
2022-2025
Bellvitge University Hospital
2015-2024
Centre for Biomedical Network Research on Rare Diseases
2022-2024
Red Espanola de Investigacion en Patologia Infecciosa
2013-2023
Centro de Investigación en Red en Enfermedades Cardiovasculares
2022
Deleted Institution
2022
Hospital Clínic de Barcelona
2022
Recent reports have revealed the existence of widespread extensively drug-resistant (XDR) P. aeruginosa high-risk clones in health care settings, but there is still scarce information on their specific chromosomal (mutational) and acquired resistance mechanisms. Up to 20 (10.5%) 190 bloodstream isolates collected from 10 Spanish hospitals met XDR criteria. A representative number (15 per group) classified as multidrug-resistant (MDR) (22.6%), resistant 1 2 classes (moderately [modR])...
Beginning in 1992, a sustained outbreak of multiresistant Acinetobacter baumannii infections was noted our 1,000-bed hospital Barcelona, Spain, resulting considerable overuse imipenem, to which the organisms were uniformly susceptible. In January 1997, carbapenem-resistant (CR) A. strains emerged and rapidly disseminated intensive care units (ICUs), prompting us conduct prospective investigation. It an 18-month longitudinal intervention study aimed at identification clinical microbiological...
From February to November 1997, 29 inpatients at Ramón y Cajal Hospital, Madrid, Spain, were determined be either colonized or infected with imipenem- and meropenem-resistant Acinetobacter baumannii (IMRAB) strains (MICs, 128 256 μg/ml). A wide antibiotic multiresistance profile was observed IMRAB strains. For typing isolates, pulsed-field gel electrophoresis used. comparative purposes, 30 meropenem-susceptible A. (IMSAB) isolated before, during, after the outbreak included in this study....
It was not until November 1989 that the 1,000-bed University-affiliated Hospital de Bellvitge "Princeps d'Espanya" in Barcelona first acquired methicillin-resistant Staphylococcus aureus (MRSA). Since time, outbreak of MRSA disease has continued. We have analyzed by genomic DNA fingerprinting 189 isolates collected between late and end 1993. The include both invasive colonizing strains as well from health-care workers environmental sources. In addition, 52 clinical methicillin-susceptible S....
Background. A dramatic decrease in the incidence of invasive pneumococcal disease (IPD) was observed among children and adults United States after introduction 7-valent conjugate vaccine (PCV7). Little is known about IPD PCV7 licensure Europe. The objective this study to examine changes prevalence era. Methods. We undertook a prospective involving with who required hospital admission southern area Barcelona, Spain. Three periods were studied: pre-PCV7 period (1997–2001), early (2002–2004),...
Sir,Vancomycin is a commonly prescribed antibiotic for the treatment of severe Gram-positive infections and drug choice caused by MRSA. 1 Vancomycin cited as having potential to exacerbate myasthenia gravis, based upon reports neuromuscular blockade potentiation when
ABSTRACT A limited number of Pseudomonas aeruginosa genotypes (mainly ST-111, ST-175, and ST-235), known as high-risk clones, are responsible for epidemics nosocomial infections by multidrug-resistant (MDR) or extensively drug-resistant (XDR) strains worldwide. We explored the potential biological parameters that may explain success these clones. total 20 isolates from each 4 resistance groups (XDR, MDR, ModR [resistant to 1 2 classes], MultiS [susceptible all antipseudomonals]), recovered a...
We investigated the presence of OprD mutations in 60 strains metallo-ß-lactamase-negative Pseudomonas aeruginosa intermediately susceptible (IS [n = 12]; MIC 8 μg/ml) or (S 48]; MICs ≤ 1 to 4 imipenem and/or meropenem that were isolated from patients with bacteremia order evaluate their impact on carbapenem susceptibility profiles. The oprD was detected by sequencing analysis. expression assessed both outer membrane protein (OMP) analysis and real-time PCR (RT-PCR). Fourteen (23%) isolates...
Whole-genome sequencing (WGS) was used for the characterization of frequently extensively drug resistant (XDR) Pseudomonas aeruginosa sequence type 175 (ST175) high-risk clone. A total 18 ST175 isolates recovered from 8 different Spanish hospitals were analyzed; 4 French included comparison. The typical resistance profile penicillins, cephalosporins, monobactams, carbapenems, aminoglycosides, and fluoroquinolones. In phylogenetic analysis, four clustered together with two one regions....
The aims of this study were to assess the risk relapse after discontinuation anti-tumor necrosis factor (anti-TNF) drugs in patients with inflammatory bowel disease (IBD), identify factors associated relapse, and evaluate overcome retreatment same anti-TNF those who relapsed.This was a retrospective, observational, multicenter study. IBD had been treated anti-TNFs whom these discontinued clinical remission achieved included.A total 1,055 included. incidence rate 19% 17% per patient-year...
We aimed to determine whether daptomycin plus fosfomycin provides higher treatment success than alone for methicillin-resistant Staphylococcus aureus (MRSA) bacteremia and endocarditis.
Antibiotic-induced modulation of the intestinal microbiota can lead to Clostridioides difficile infection (CDI), which is associated with considerable morbidity, mortality, and healthcare-costs globally. Therefore, identification markers predictive CDI could substantially contribute guiding therapy decreasing burden. Here, we analyze hospitalized patients at increased risk in a prospective, 90-day cohort-study before after antibiotic treatment diarrhea onset. We show that developing already...
Fecal colonization with multiresistant Acinetobacter baumannii was evaluated in 189 consecutive patients intensive care units (ICUs) during two different 2-month periods (October–November 1993 and May–June 1994). Rectal swabs were obtained weekly from admission to discharge the ICU. Overall, 77 (41%) had A. fecal colonization; detected 55(71%) of within first week their ICU stay. Clinical infections due occurred more frequently than those without (26% vs. S%, respectively; P < .001). The...
Journal Article Decreased susceptibility of penicillin-resistant pnenmococci to twenty-four βlactam antibiotics Get access J. Liñares, Liñares * aService Microbiology; Hospital de Bellvitge, Universidad BarcelonaBarcelona, Spain *Corresponding author Service Microbiology. Feixa Llarga a/n, 08907 Hospitalet Liobregat, Barcelona, Search for other works by this on: Oxford Academic PubMed Google Scholar T. Alonso, Alonso J.L. Pérez, Pérez Ayats, Ayats M.A. Dominguez, Dominguez R. Pallarés,...
Trains equipped with automatic train operation (ATO) systems are operated between stations according to the speed commands they receive from balises. These define a particular profile and running time, associated energy usage (consumption). The design of profiles usually takes into account times comfort criteria, but not consumption criteria. In this article, computer-aided procedure for selection optimal profiles, including consumption, which does have an effect on times, is presented. To...
ABSTRACT The potential role of Pseudomonas aeruginosa (PA) intestinal colonization in the subsequent development infections has not been thoroughly investigated. aims this study were to assess PA as a predictor and investigate risk factors associated with infection patients intensive care unit (ICU). For purpose, prospective was conducted that included (i) active surveillance rectal at ICU admission weekly until discharge, (ii) detection clinical infections, (iii) genotypic analysis by...
The prevalence of a new hypervirulent and hypermucoviscous K. pneumoniae phenotype (Hmv) is increasing worldwide, mainly linked to serotypes K1 K2. Since capsular thickness can directly affect the capability form biofilms, we aimed evaluate association between Hmv with adhesion biofilm formation in collection clinical isolates. We selected 38 isolates [15 serotype K1; 9 K2; 3 non-K1/K2 (rmpA+); 11 (rmpA-)] 7 non-Hmv was assessed through mucoviscosity test. Serum resistance determined by...