A5069496269- Pharmacogenetics and Drug Metabolism
- SARS-CoV-2 and COVID-19 Research
- COVID-19 Clinical Research Studies
- Pharmaceutical studies and practices
- Antibiotics Pharmacokinetics and Efficacy
- Health Systems, Economic Evaluations, Quality of Life
- Poisoning and overdose treatments
- Pharmacological Effects and Toxicity Studies
- Renal Transplantation Outcomes and Treatments
- Statistical Methods in Clinical Trials
- Ethics in Clinical Research
- Long-Term Effects of COVID-19
- Pharmaceutical Practices and Patient Outcomes
- Drug-Induced Hepatotoxicity and Protection
- Analytical Methods in Pharmaceuticals
- Pharmacovigilance and Adverse Drug Reactions
- Antibiotic Resistance in Bacteria
- Pneumonia and Respiratory Infections
- Antifungal resistance and susceptibility
- Drug-Induced Adverse Reactions
- Drug Transport and Resistance Mechanisms
- Cancer Treatment and Pharmacology
- Biosimilars and Bioanalytical Methods
- Atrial Fibrillation Management and Outcomes
- Blood disorders and treatments
Universidad Autónoma de Madrid
2016-2025
Hospital Universitario La Paz
2015-2024
Hospital La Paz Institute for Health Research
2019-2024
Centro de Investigación Biomédica en Red
2022-2023
Instituto de Salud Carlos III
2023
Spanish Clinical Research Network
2017-2023
Madrid Health Service
2022-2023
European Union
2023
University of Minnesota
2021
Puigvert Foundation
2004
BackgroundTo date, no immunological data on COVID-19 heterologous vaccination schedules in humans have been reported. We assessed the immunogenicity and reactogenicity of BNT162b2 (Comirnaty, BioNTech, Mainz, Germany) administered as second dose participants primed with ChAdOx1-S (Vaxzevria, AstraZeneca, Oxford, UK).MethodsWe did a phase 2, open-label, randomised, controlled trial adults aged 18–60 years, vaccinated single 8–12 weeks before screening, history SARS-CoV-2 infection....
Background: Since the confirmation of first patient infected with SARS-CoV-2 in Spain January 2020, epidemic has grown rapidly, greatest impact on region Madrid. This article describes 2226 adult patients COVID-19, consecutively admitted to La Paz University Hospital Methods: Our cohort included all hospitalized who had a final outcome (death or discharge) 1286-bed hospital Madrid (Spain) from 25 February (first case admitted) 19 April 2020. The data were manually entered into an electronic...
Objective To develop and validate a prediction model of mortality in patients with COVID-19 attending hospital emergency rooms. Design Multivariable prognostic model. Setting 127 Spanish hospitals. Participants Derivation (DC) external validation (VC) cohorts were obtained from multicentre single-centre databases, including 4035 2126 confirmed COVID-19, respectively. Interventions Prognostic variables identified using multivariable logistic regression. Main outcome measures 30-day mortality....
Background/Objectives: Post-market surveillance of COVID-19 vaccines is vital. This study analyzed EudraVigilance data (Jan 2021–Dec 2023) to detect potential safety signals linking and specific neurological adverse events (aseptic meningitis, Guillain–Barré syndrome, polyradiculoneuropathies, multiple sclerosis, transverse myelitis, neuromyelitis optica). It also explored the impact non-healthcare professional reports on disproportionality analysis. Methods: were quantify for 5 47...
This study evaluated maintenance with lopinavir/ritonavir monotherapy vs. continuing and 2 nucleosides in HIV-infected patients suppressed HIV replication.Randomized, controlled, open-label, multicenter, pilot clinical trial.Adult were eligible if they had no history of virologic failure while receiving a protease inhibitor, + (400/100 mg b.i.d.) for >1 month maintained serum RNA <50 copies/mL >6 months prior to enrollment.Forty-two randomly assigned 1:1 continue or stop the nucleosides. At...
Study objectiveThe objective of the InMEDIATE study was to evaluate change in intensity traumatic pain over first 20 min adult patients treated with methoxyflurane versus standard analgesic treatment Spain. This randomized, active-controlled, multicenter trial emergency setting Europe.MethodsThis a controlled that enrolled acute moderate severe (score ≥4 on 11-point Numeric Rating Scale) trauma-associated 14 Spanish departments. Patients were randomized 1:1 (up 2×3 mL) or treatment....
WHAT IS ALREADY KNOWN ABOUT THIS SUBJECT • In USA and Europe the classical way to guarantee equivalence between different formulations is bioequivalence (BE) study based on in vivo bioavailability. The Biopharmaceutic Classification System (BCS) classifies active substances into four groups according their aqueous solubility intestinal permeability. Recently European Medicines Agency (EMA) has released a new guideline for immediate release solid oral dosage forms that includes...
The detection and reporting of serious adverse drug reactions (SADRs) have become important components monitoring evaluation activities performed in hospitals. We present the implementation a prospective pharmacovigilance program based on automatic laboratory signals (ALSs) at hospital. also report general findings after first year operation program, which involved ALSs that indicate various SADRs: agranulocytosis, aplastic anemia, liver injury, thrombocytopenia, hyponatremia,...
There is evidence showing the importance of reaching immunosuppressant target concentrations as soon possible. The aim this study was to evaluate relationship between tacrolimus trough within first week after transplantation and rate acute rejection. In descriptive-analytic study, we included 57 renal transplant patients receiving primary immunosuppressive drug. After univariate analysis, donor age, duration hospital stay, creatinine clearance (third month) showed significant differences...
Background: The first generic PPI was introduced in Spain 2001, and since then their prescriptions have increased steadily by about 200%. Aim: To evaluate the frequency of use appropriateness indications PPIs hospitalised patients, possible factors predicting use. We also evaluated relevant PPI-drug interactions serious adverse drug reactions (SADRs). Methods: This a cross-sectional, prescription-indication drug-utilisation study patients with follow-up until discharge. Sampling random...
Appropriate dosing of coumarins is difficult to establish, due significant inter-individual variability in the dose required obtain stable anticoagulation. Several genetic and other clinical factors have been associated with dose, some pharmacogenetic-guided algorithms for warfarin acenocoumarol developed mixed populations. We recruited 147 patients thromboembolic disease who were on doses an international normalized ratio (INR) between 2 3. ascertained influence variables by multiple linear...
The coronavirus disease 2019 (COVID-19) pandemic has evidenced the key role of vaccine design, obtention, production and administration to successfully fight against infectious diseases provide efficient remedies for citizens. Although clinical trials were rapidly established during this pandemic, identifying suitable study subjects can be challenging. For reason, University Hospital Cologne a volunteer registry participation in first Germany, which now been incorporated into European...
Abstract In 2014, we established a pharmacogenetics unit with the intention of facilitating integration pharmacogenetic testing into clinical practice. This was centered around two main ideas: i) individualization recommendations, and ii) preemptive genotyping in risk populations. Our is based on design validation single nucleotide polymorphism (SNP) microarray, which has allowed 180 SNPs associated drug response (PharmArray), consultation regarding results. Herein, report our experience...
Transfusion of blood components continues to be an important therapeutic resource into the 21st century. Between 5 and 58% transfusions carried out are estimated unnecessary. According several studies, at least 20% packed red cell (RBCT) administered in hospital emergency departments (ED), but few data available about appropriateness RBCT this setting. This multicentre, cross-sectional observational study aims assess indications transfused volumes patients who attend ED.The cohort is made up...
Effective treatments are still needed to reduce the severity of symptoms, time hospitalization, and mortality COVID-19. SARS-CoV-2 specific memory T-lymphocytes obtained from convalescent donors recovered can be used as passive cell immunotherapy.Between September November 2020 a phase 1, dose-escalation, single centre clinical trial was conducted evaluate safety feasibility infusion CD45RA- T cells containing adoptive therapy against moderate/severe cases Nine participants with pneumonia...
To study the penetration of tobramycin in lung tissue evaluated as concentration epithelial lining fluid and to characterize time course drug treatment patients with pneumonia.The subjects were 16 pneumonia taking who had clinical indications for bronchoscopy. Bronchoscopy bronchoalveolar lavage pneumonic area was performed once on each patient 1/2%, 2, 4, or 8 hours after previous dose. Urea used an endogenous marker quantification obtained at lavage. Tobramycin concentrations serum...
A 55-years-old woman was diagnosed with pneumonia and treated meropenem; 5 days later she developed epileptic seizures. She had been valproic acid for 16 years to control her Her serum concentration low during treatment meropenem than previously recorded despite an increase of dose. As soon as administration withdrawn, increased previous levels seizures stopped. Meropenem decreases concentration, may promote the development in controlled patients. The acute lowering valproate produced by...
We conducted a prospective evaluation of all eosinophilic drug reactions (EDRs) through the Prospective Pharmacovigilance Program from Laboratory Signals at Hospital to find out incidence and distribution these entities in our hospital, their causative drugs, predictors.All peripheral eosinophilia >700 × 106 cells l-1 detected admission or during hospitalisation, were prospectively monitored over 42 months. The spectrum localised systemic manifestation EDR, incidence, predictors analysed.The...