Simin Aysel Florescu
A5088539793- COVID-19 Clinical Research Studies
- Mosquito-borne diseases and control
- Viral Infections and Vectors
- Hepatitis C virus research
- SARS-CoV-2 and COVID-19 Research
- Malaria Research and Control
- Infective Endocarditis Diagnosis and Management
- Liver Disease Diagnosis and Treatment
- Travel-related health issues
- Herpesvirus Infections and Treatments
- Antibiotic Resistance in Bacteria
- Antibiotic Use and Resistance
- Bacterial Infections and Vaccines
- Tuberculosis Research and Epidemiology
- Hepatitis B Virus Studies
- Antimicrobial Resistance in Staphylococcus
- Bacillus and Francisella bacterial research
- Poxvirus research and outbreaks
- Antibiotics Pharmacokinetics and Efficacy
- Long-Term Effects of COVID-19
- Diagnosis and treatment of tuberculosis
- COVID-19 and healthcare impacts
- Viral gastroenteritis research and epidemiology
- Viral Infections and Outbreaks Research
- Streptococcal Infections and Treatments
Carol Davila University of Medicine and Pharmacy
2016-2025
Spitalul Clinic Dr. Victor Babes
2016-2025
Academy of Medical Sciences
2024
European Society of Clinical Microbiology and Infectious Diseases
2021
Institute for Research and Development
2021
Institute of Virology of the Slovak Academy of Sciences
2021
University Hospital Cologne
2021
University of Zurich
2018
National Institute of Research and Development for Biological Sciences
2016
Overactivation of the renin-angiotensin system (RAS) may contribute to poor clinical outcomes in patients with COVID-19.
<h2>Abstract</h2><h3>Objectives</h3> To assess the mortality attributable to infections caused by carbapenem-resistant Enterobacterales (CRE) and investigate effect of clinical management on differences in observed outcomes a multinational matched cohort study. <h3>Methods</h3> A prospective matched-cohorts study (NCT02709408) was performed 50 European hospitals from March 2016 November 2018. The main outcome 30-day with an active post-discharge follow-up when applied. CRE included patients...
Yellow fever virus is a mosquito-borne flavivirus that causes yellow fever, an acute infectious disease occurs in South America and sub-Saharan Africa. Most patients with are asymptomatic, but among the 15% who develop severe illness, case fatality rate 20%-60%. Effective live-attenuated vaccines available protect against (1). An outbreak of began Brazil December 2016; since July 2017, cases both humans nonhuman primates have been reported from states São Paulo, Minas Gerais, Rio de Janeiro,...
Antibiotic-induced modulation of the intestinal microbiota can lead to Clostridioides difficile infection (CDI), which is associated with considerable morbidity, mortality, and healthcare-costs globally. Therefore, identification markers predictive CDI could substantially contribute guiding therapy decreasing burden. Here, we analyze hospitalized patients at increased risk in a prospective, 90-day cohort-study before after antibiotic treatment diarrhea onset. We show that developing already...
The efficacy of vitamin C for hospitalized patients with COVID-19 is uncertain.
Disease epidemiology of (re-)emerging infectious diseases is changing rapidly, rendering surveillance travel-associated illness important.We evaluated travel-related encountered at EuroTravNet clinics, the European sub-network GeoSentinel, between March 1, 1998 and 31, 2018.103,739 ill travellers were evaluated, including 11,239 (10.8%) migrants, 89,620 (86.4%) patients seen post-travel, 2,880 (2.8%) during after travel. Despite increasing numbers patient encounters over 20 years, regions...
Prolonged diarrhoea is common amongst returning travellers and often caused by intestinal protozoa. However, the epidemiology of travel-associated illness protozoal pathogens not well described.
Background: Carbapenem-resistant Klebsiella pneumoniae (Cr-Kpn) is becoming a growing public health problem through the failure of adequate treatment. This study’s objectives are to describe sources Cr-Kpn in our hospital over 22 months, associating factors with outcome Cr-Kpn-positive patients, especially those NDM+OXA-48-like (New Delhi Metallo-β-Lactamase and oxacillinase-48), effectiveness treatments used. Methods: A retrospective observational cohort study including all hospitalized...
Background/Objectives: Although a “forgotten” disease in developed countries, typhoid fever remains significant global health problem, especially regions with inadequate sanitation and overcrowding. Despite medical advances, this systemic bacterial infection, caused by Salmonella Typhi, continues to affect millions worldwide. Accurate diagnosis timely treatment are crucial prevent severe complications mortality. Even though antibiotic therapy is effective, the emergence of drug-resistant...
We evaluated clinical effectiveness of regdanvimab (CT-P59), a severe acute respiratory syndrome coronavirus 2 neutralizing monoclonal antibody, in reducing disease progression and recovery time patients with mild-to-moderate 2019 (COVID-19), primarily Alpha variant.This was phase 3 2/3 parallel-group, double-blind, randomized trial. Outpatients COVID-19 were to single-dose 40 mg/kg (n = 656) or placebo 659), alongside standard care. The primary endpoint up day 28 among "high-risk" patients....
We characterized influenza B virus-related neurologic manifestations in an unusually high number of hospitalized adults at a tertiary care facility Romania during the 2014-15 epidemic season. Of 32 patients with confirmed laboratory diagnosis virus infection, complications developed 7 (median age 31 years). These were clinically diagnosed as encephalitis (4 patients), possible (2 and cerebellar ataxia (1 patient). Two died. Virus sequencing identified (Yam)-lineage clade 3, which is...
Abstract Trial enrichment using gut microbiota derived biomarkers by high-risk individuals can improve the feasibility of randomized controlled trials for prevention Clostridioides difficile infection (CDI). Here, we report in a prospective observational cohort study incidence CDI and assess potential clinical characteristics to predict 1,007 patients ≥ 50 years receiving newly initiated antibiotic treatment with penicillins plus beta-lactamase inhibitor, 3 rd /4 th generation...
European countries have included healthcare workers (HCWs) among priority groups for COVID-19 vaccination. We established a multi-country hospital network to measure the SARS-CoV-2 incidence and effectiveness of vaccines HCWs against laboratory-confirmed infection.
Abstract We describe a series of severe neuroinvasive infections caused by Toscana virus, identified real-time reverse transcription PCR testing, in 8 hospitalized patients Bucharest, Romania, during the summer seasons 2017 and 2018. Of patients, 5 died. Sequencing showed that circulating virus belonged to lineage A.