A5020989510- Parasites and Host Interactions
- Mosquito-borne diseases and control
- Malaria Research and Control
- Parasite Biology and Host Interactions
- Trypanosoma species research and implications
- COVID-19 Clinical Research Studies
- Travel-related health issues
- Research on Leishmaniasis Studies
- Viral Infections and Vectors
- SARS-CoV-2 and COVID-19 Research
- Helminth infection and control
- Long-Term Effects of COVID-19
- Global Maternal and Child Health
- Parasitic Infections and Diagnostics
- Parasitic Diseases Research and Treatment
- Prostate Cancer Treatment and Research
- Tuberculosis Research and Epidemiology
- Hepatitis Viruses Studies and Epidemiology
- Parasitic infections in humans and animals
- Prostate Cancer Diagnosis and Treatment
- COVID-19 epidemiological studies
- Data Analysis with R
- Vector-borne infectious diseases
- HIV Research and Treatment
- Dermatological diseases and infestations
Hospital Clínic de Barcelona
2009-2025
Universitat de Barcelona
2016-2025
Barcelona Institute for Global Health
2016-2025
Centro de Investigación Biomédica en Red
2023-2024
Departament de Salut
2024
Instituto de Salud Carlos III
2016-2024
Universidad Andrés Bello
2023-2024
Hospital de Sant Pau
2001-2023
Instituto Tecnológico de Santo Domingo
2023
California Polytechnic State University
2022-2023
Remdesivir is an RNA polymerase inhibitor with potent antiviral activity in vitro and efficacy animal models of coronavirus disease 2019 (Covid-19). We conducted a randomized, open-label, phase 3 trial involving hospitalized patients confirmed SARS-CoV-2 infection, oxygen saturation 94% or less while they were breathing ambient air, radiologic evidence pneumonia. Patients randomly assigned 1:1 ratio to receive intravenous remdesivir for either 5 days 10 days. All received 200 mg on day 1 100...
Abstract Health care workers (HCW) are a high-risk population to acquire SARS-CoV-2 infection from patients or other fellow HCW. This study aims at estimating the seroprevalence against in random sample of HCW large hospital Spain. Of 578 participants recruited 28 March 9 April 2020, 54 (9.3%, 95% CI: 7.1–12.0) were seropositive for IgM and/or IgG IgA SARS-CoV-2. The cumulative prevalence (presence antibodies past current positive rRT-PCR) was 11.2% (65/578, 8.8–14.1). Among those with...
Background The diagnosis of Strongyloides stercoralis (S. stercoralis) infection is hampered by the suboptimal sensitivity fecal-based tests. Serological methods are believed to be more sensitive, although assessing their accuracy difficult because lack a reference ("gold") standard. Methods and specificity 5 serologic tests for S. (in-house IFAT, NIE-ELISA NIE-LIPS commercially available Bordier-ELISA IVD-ELISA) were assessed on 399 cryopreserved serum samples. Accuracy was measured using...
Trastuzumab resistance hampers its well-known efficacy to control HER2-positive breast cancer. The involvement of PI3K/Akt pathway in this mechanism is still not definitively confirmed. We selected 155 patients treated with trastuzumab after development metastasis or as adjuvant/neoadjuvant therapy. performed immunohistochemistry for HER2, ER/PR, epidermal growth factor 1-receptor (EGFR), α-insulin-like (IGF1R), phosphatase and tensin homologue (PTEN), p110α, pAkt, pBad, pmTOR, pMAPK, MUC1,...
To evaluate the outcome of elderly patients with community-acquired pneumonia (CAP) seen at an acute-care hospital, analyzing importance CAP severity, functional status, comorbidity, and frailty.Prospective observational study.Emergency department geriatric medical day hospital a university teaching hospital.Ninety-nine aged 65 older for over 6-month recruitment period.Clinical data were used to calculate Pneumonia Severity Index (PSI), Barthel (BI), Charlson Comorbidity Index, Hospital...
ABSTRACT Chagas’ disease is an emerging public health problem in areas where the not endemic. Treatment with benznidazole has shown efficacy acute stage of disease, but its chronic remains controversial, and unwanted side effects are more frequent severe adults than children. This study describes profile a cohort Trypanosoma cruzi -infected patients European country.
Nocardiosis has been believed to be caused by the members of Nocardia asteroides complex and brasiliensis species. However, recent advances in genotypic identification have shown that genus exhibits considerable taxonomic complexity phenotypic markers used past for its can ambiguous. The aim this study was assess species distribution isolates determine whether there are differences pathogenicity or antimicrobial susceptibility between different identified. obtained over a 7 year period were...
We performed a prospective screening for Trypanosoma cruzi infection in 1350 Latin American pregnant women and their offspring Barcelona, Spain. The rate of seroprevalence was 3.4%, 7.3% the newborns were infected. Routine management programs maternity wards may be warranted.
Background Traditional faecal-based methods have poor sensitivity for the detection of S. stercoralis, therefore are inadequate post-treatment evaluation infected patients who should be carefully monitored to exclude persistence infection. In a previous study, we demonstrated high accuracy five serology tests screening and diagnosis strongyloidiasis. Aim this study is evaluate performance same follow up with stercoralis. Methods Retrospective on anonymized, cryo-preserved samples available...
Controlled human malaria infection (CHMI) accelerates development of anti-malarial interventions. So far, CHMI is done by exposure volunteers to bites five mosquitoes carrying Plasmodium falciparum sporozoites (PfSPZ), a technique available in only few centres worldwide. Mosquito-mediated logistically complex, exact PfSPZ dosage impossible and live mosquito-based interventions are not suitable for further clinical development. An open-labelled, randomized, dose-finding study 18–45 year old,...