Celia Cardozo
A5057631003- COVID-19 Clinical Research Studies
- Antifungal resistance and susceptibility
- Bacterial Identification and Susceptibility Testing
- Long-Term Effects of COVID-19
- Antibiotic Use and Resistance
- Antibiotic Resistance in Bacteria
- Neutropenia and Cancer Infections
- Fungal Infections and Studies
- Antibiotics Pharmacokinetics and Efficacy
- SARS-CoV-2 and COVID-19 Research
- Pneumocystis jirovecii pneumonia detection and treatment
- Central Venous Catheters and Hemodialysis
- Pneumonia and Respiratory Infections
- Sepsis Diagnosis and Treatment
- COVID-19 and healthcare impacts
- Nosocomial Infections in ICU
- Streptococcal Infections and Treatments
- Blood disorders and treatments
- Hematopoietic Stem Cell Transplantation
- Urinary Tract Infections Management
- Infective Endocarditis Diagnosis and Management
- COVID-19 and Mental Health
- Plant Pathogens and Fungal Diseases
- SARS-CoV-2 detection and testing
- Nail Diseases and Treatments
Hospital Clínic de Barcelona
2016-2025
Consorci Institut D'Investigacions Biomediques August Pi I Sunyer
2016-2025
Universitat de Barcelona
2014-2025
Icesi University
2014-2021
Universidad del Valle
2021
Johns Hopkins Medicine
2020
Johns Hopkins University
2020
National Institutes of Health
2020
Barcelona Institute for Global Health
2017
Office of Infectious Diseases
2017
Time to positivity (TTP) and differential TTP (DTP) emerge as diagnostic prognostic tools for bloodstream infections (BSI) though specific cut-off values need be determined each pathogen. Pseudomonas aeruginosa BSI (PAE-BSI) is of critical concern, particularly in immunocompromised patients, due high mortality rates. Catheter-related are a common cause, necessitating rapid accurate effective management (source-control). Unicentric retrospective observational study analyzing the utility best...
Abstract Background We aimed to describe the current rates of inappropriate empirical antibiotic treatment (IEAT) in oncohematological patients with febrile neutropenia (FN) and its impact on mortality. Methods This was a multicenter prospective study all episodes bloodstream infection (BSI) high-risk FN (2006–2017). Episodes receiving IEAT were compared appropriate therapy. Adherence Infectious Diseases Society America (IDSA) recommendations evaluated. Multivariate analysis performed...
Alternatives to conventional hospitalization are needed increase health systems resilience in the face of COVID-19 pandemic. Herein, we describe characteristics and outcomes 63 patients admitted a single HaH during peak Barcelona. Our results suggest that seems be safe efficacious alternative for accurately selected with COVID-19.
BackgroundCalcium is an essential ion for pathogen survival and virulence involved in the regulation of inflammatory response. Hypocalcemia a common laboratory finding critically ill patients. Data regarding levels calcium SARS-CoV-2 infection scarce. Patients with who present hypocalcemia could have worse outcome.MethodsWe performed retrospective analysis hospitalized patients included all had any serum measurement first 72 h since hospital admission. The main objective was to investigate...
We aimed to describe changes in characteristics and treatment strategies of hospitalised patients with COVID-19 detail the mortality trend over time.
Abstract Background The use of remdesivir has demonstrated a significant reduction in the time to recovery patients with COVID-19. However, impact on mortality is still controversial. Therefore, it necessary evaluate whether there specific subgroup whom an active antiviral therapy also reduces mortality. Methods Patients admitted for >48 h our hospital SARS-CoV-2 confirmed or suspected infection from February 2020 2021 were retrospectively analysed. primary outcome study was at 30...
Staphylococcus aureus is a common cause of serious infections. One the main drawbacks in its treatment time required for positive diagnosis, over 24 h, as most methods are still based bacterial culture. Herein, microfluidic optical device rapid and ultrasensitive quantification S. real human fluids designed. In this approach, surface‐enhanced Raman scattering (SERS)‐encoded particles, functionalized with either an antibody or aptamer, form dense collection electromagnetic hot spots on...
Abstract Hospitalized patients with coronavirus disease 2019 (COVID-19) experiencing respiratory symptoms have different complications (inflammatory, co-infection, and thrombotic) that are identifiable by analytics patterns. Personalized treatment decisions decreased early mortality (odds ratio [OR] .144; 95% confidence interval [CI] .03–.686; P = .015). Increasing age (OR 1.06; .038) therapeutic effort limitation 9.684; < .001) were associated higher mortality.
We aimed to assess the rate and predictive factors of bloodstream infection (BSI) due multidrug-resistant (MDR) Pseudomonas aeruginosa in neutropenic cancer patients. performed a multicenter, retrospective cohort study including oncohematological patients with BSI P. conducted across 34 centers 12 countries from January 2006 May 2018. A mixed logistic regression model was used estimate predict multidrug resistance causative pathogens.
To test the hypothesis that addition of an aminoglycoside to a β-lactam antibiotic could provide better outcomes than monotherapy for initial empirical treatment hematological neutropenic patients with subsequently documented Gram-negative bacillus (GNB) bloodstream infection (BSI), multinational, retrospective, cohort study GNB BSI episodes in six centers (2010 2017) was conducted. Combination therapy (β-lactam plus aminoglycoside) compared monotherapy. The primary endpoint case fatality...
We aimed to assess risk factors for multidrug-resistant Gram-negative bacilli (MDR-GNB) from a large amount of data retrieved electronic health records (EHRs) and determine whether machine learning (ML) may be useful in assessing the MDR-GNB infection at febrile neutropenia (FN) onset. Retrospective study almost 7 million pieces structured all consecutive episodes FN hematological patients tertiary hospital Barcelona (January 2008–December 2017). Conventional multivariate analysis ML...
Despite improvements in the clinical management of patients with community-acquired pneumonia (CAP) over last decade, incidence condition remains high, especially Europe. Globally, continues to be associated high morbidity, mortality, and health costs. Moreover, its poses many challenges. The microbial identification pathogens difficult even though new molecular tests have been developed, mainly because difficulties interpreting results. Also, epidemiological changes due serotype replacement...
Abstract Background In some patients the immune response triggered by SARS-CoV-2 is unbalanced, presenting an acute respiratory distress syndrome which in many cases requires intensive care unit (ICU) admission. The limitation of ICU beds has been one major burdens management worldwide; therefore, clinical strategies to avoid admission are needed. Objective We aimed describe influence tocilizumab on need transfer or death non-critically ill patients. Methods A retrospective study 171 with...
Tumor Necrosis Factor-alpha (TNF-α) is an immunomodulatory and proinflammatory cytokine implicated in neuro-inflammation neuronal damage response to cerebral ischemia. The present study tested the hypothesis that anti-TNF-α agents may be protective against infarction. Transient focal ischemia was artificially induced anesthetized adult male Wistar rats (300-350 g) by middle artery occlusion (MCAO) with intraluminal suture. TNF-α function interfered either a chimeric monoclonal antibody...