A5079580909- Neutropenia and Cancer Infections
- Antibiotic Resistance in Bacteria
- Bacterial Identification and Susceptibility Testing
- Antibiotics Pharmacokinetics and Efficacy
- Mycobacterium research and diagnosis
- Antibiotic Use and Resistance
- Prostate Cancer Treatment and Research
- Respiratory viral infections research
- Influenza Virus Research Studies
- Antifungal resistance and susceptibility
- Fungal Infections and Studies
- Bone and Joint Diseases
- Hematological disorders and diagnostics
- Prostate Cancer Diagnosis and Treatment
- Viral gastroenteritis research and epidemiology
- Pneumocystis jirovecii pneumonia detection and treatment
- Clostridium difficile and Clostridium perfringens research
- COVID-19 and healthcare impacts
- Viral Infectious Diseases and Gene Expression in Insects
- Bladder and Urothelial Cancer Treatments
- Virus-based gene therapy research
- Urinary Tract Infections Management
- COVID-19 Clinical Research Studies
- Streptococcal Infections and Treatments
- Health Systems, Economic Evaluations, Quality of Life
Centro de Educación Médica e Investigaciones Clínicas Norberto Quirno
2016-2025
University Hospital of Lausanne
2023
Universidad de Granada
2020
Instituto Andaluz de Ciencias de la Tierra
2020
Office of Infectious Diseases
2010
Hôpital Nord
2007
Currently, Coronavirus disease (COVID-19), one of the most infectious diseases in 21st century, is diagnosed using RT-PCR testing, CT scans and/or Chest X-Ray (CXR) images. (Computed Tomography) scanners and testing are not available medical centers hence many cases CXR images become time/cost effective tool for assisting clinicians making decisions. Deep learning neural networks have a great potential building COVID-19 triage systems detecting patients, especially patients with low...
Few studies have evaluated the efficacy of ceftazidime–avibactam (CA) for Klebsiella pneumoniae carbapenemase-producing Enterobacterales bacteremia (KPC-PEB) in high-risk neutropenic patients. This is a prospective multicenter observational study patients with multi-drug resistant bacteremia. They were compared according to resistance mechanism and definitive treatment provided: KPC-CPE treated CA (G1), other antibiotics (G2), ESBL-producing who received appropriate therapy (G3). Thirty-day...
ABSTRACT β-Lactam/β-lactamase inhibitors (BLBLIs) were compared to carbapenems in two cohorts of hematological neutropenic patients with extended-spectrum-β-lactamase (ESBL) bloodstream infection (BSI): the empirical therapy cohort (174 patients) and definitive (251 patients). The 30-day case fatality rates other secondary outcomes similar groups also propensity-matched cohorts. BLBLIs might be carbapenem-sparing alternatives for treatment BSI due ESBLs these patients.
We aimed to assess the rate and predictive factors of bloodstream infection (BSI) due multidrug-resistant (MDR) Pseudomonas aeruginosa in neutropenic cancer patients. performed a multicenter, retrospective cohort study including oncohematological patients with BSI P. conducted across 34 centers 12 countries from January 2006 May 2018. A mixed logistic regression model was used estimate predict multidrug resistance causative pathogens.
We aimed to describe the epidemiology, risk factors, and clinical outcomes of co-infections superinfections in onco-hematological patients with COVID-19.International, multicentre cohort study cancer COVID-19. All were included analysis at diagnosis, while only admitted least 48 h superinfections.684 (384 solid tumors 300 hematological malignancies). Co-infections documented 7.8% (54/684) 19.1% (113/590) patients, respectively. Lower respiratory tract infections most frequent infectious...
To test the hypothesis that addition of an aminoglycoside to a β-lactam antibiotic could provide better outcomes than monotherapy for initial empirical treatment hematological neutropenic patients with subsequently documented Gram-negative bacillus (GNB) bloodstream infection (BSI), multinational, retrospective, cohort study GNB BSI episodes in six centers (2010 2017) was conducted. Combination therapy (β-lactam plus aminoglycoside) compared monotherapy. The primary endpoint case fatality...
This large, multicenter, retrospective cohort study including onco-hematological neutropenic patients with Pseudomonas aeruginosa bloodstream infection (PABSI) found that among 1213 episodes, 411 (33%) presented septic shock. The presence of solid tumors (33.3% vs. 20.2%, p < 0.001), a high-risk Multinational Association for Supportive Care in Cancer (MASCC) index score (92.6% 57.4%; pneumonia (38% 19.2% and due to multidrug-resistant P. (MDRPA) (33.8% 21.1%, 0.001) were statistically...
We describe an outbreak of Klebsiella pneumoniae sequence type 11 (ST11) producing KPC variants resistant to ceftazidime-avibactam. Six patients hospitalized in the intensive care unit (mostly due critical COVID pneumonia) presented infection or colonization by this bacterium. They had several comorbidities and required mechanical ventilation, central venous catheters, urinary catheters. All 6 a history fecal with KPC-producing Enterobacterales (KPC-E). Three them previous episodes...
Identifying the risk factors for carbapenem-resistant Enterobacterales (CRE) bacteremia in cancer and hematopoietic stem cell transplantation (HSCT) patients would allow earlier initiation of an appropriate empirical antibiotic treatment. This is a prospective multicenter observational study from 12 centers Argentina, who presented with or stem-cell transplant developed bacteremia. A multiple logistic regression model identified CRE bacteremia, score was according to coefficient. validated...
Abstract Background Carbapenemase-producing Enterobacterales infections (CPEi) often have poor prognosis and high mortality. However, no local studies compare KPC NDM-CPEi treated with ceftazidime-avibactam (CA) or plus aztreonam (CA+ATM). Methods Prospective cohort study. We included episodes of in patients admitted to a university hospital (from August 2018 April 2023) who received definitive antibiotic treatment (AT) CA CA+ATM, respectively. compared clinical characteristics outcomes...
Abstract Background Ceftazidime-avibactam (CA) and CA plus aztreonam (ATM) are the preferred treatment options for KPC metallo-beta-lactamase (MBL) carbapenemase-producing Enterobacterales bacteremia (CPEB). However, data regarding short therapy scarce. Methods Prospective observational cohort study performed in a university hospital Argentina between August 2018 February 2024. All adult patients with CPEB who received adequate empirical or CA+ATM, median duration of 7 days (IQR: 7-8),...
Abstract Background Ceftazidime-avibactam (CA) and CA plus aztreonam (ATM) are the preferred treatment options for KPC metallo-beta-lactamase (MBL) carbapenemase-producing Enterobacterales infections (KPC-CPE MBL-CPE), respectively. There not many studies in immunocompromised patients (IP). Methods Observational prospective cohort study. All episodes of KPC-CPE MBL-CPE IP admitted to a university hospital from August 2018 April 2023, who received definitive antibiotic therapy (DAT) with or...
Abstract Background The epidemiology of bacteremia (B) in neutropenic patients (NP) may differ according to the geographic region or country and can change over time. growing rate multidrug-resistant gram-negative bacilli (MDR-GNB) is usually associated with higher mortality. Methods Prospective multicenter study. All first episodes B adult NP hematologic malignancies were included 9 centers Argentina, from May 2014 December 2023. They divided three periods: 2014-June 2017 (P1), July...
During March 2009 a novel Influenza A virus emerged in Mexico. We describe the clinical picture of pandemic (H1N1) cancer patients during influenza season.Twelve centers participated multicenter retrospective observational study with confirmed infection H1N1 (influenza-like illness or pneumonia plus positive PCR for respiratory secretions). Clinical data were obtained by chart review and analyzed. From May to August 2009, 65 collected. Median age was 51 years, 57 % female. Most (47) had...
Objectives: To assess the clinical features and outcomes of Pseudomonas aeruginosa bloodstream infection (PA BSI) in neutropenic patients with hematological malignancies (HM) solid tumors (ST), identify risk factors for 30-day mortality. Methods: We performed a large multicenter, retrospective cohort study including onco-hematological PA BSI conducted across 34 centers 12 countries (January 2006−May 2018). Episodes occurring hematologic were compared to those developing ST. Risk associated...
<ns4:p><ns4:bold>Background: </ns4:bold>During March 2009 a novel <ns4:italic>Influenza A</ns4:italic> virus emerged in Mexico. We describe the clinical picture of pandemic (H1N1) Influenza cancer patients during influenza season.</ns4:p><ns4:p><ns4:bold>Methods: </ns4:bold>Twelve centers participated multicenter retrospective observational study with confirmed infection H1N1 (influenza-like illness or pneumonia plus positive PCR for respiratory secretions). Clinical data were obtained by...
Data about short courses of antibiotic therapy for Gram-negative bacilli (GNB) bacteremia in immunosuppressed patients are limited. This is a prospective observational study performed on adult with cancer and hematopoietic stem cell transplant (HSCT) who developed GNB received appropriate empirical (EAT), had clinical response within 7 days survived 48 h after the end therapy. They range 7-15 were divided into course, median (SC), or long 14 (LC). Seventy-four included (SC: 36 LC: 38). No...
We retrospectively assessed the renal toxicity associated with use of intravenous colistin. Fifty-four patients multidrug-resistant Acinetobacter infections were included. At end therapy 6/54 (11%) suffered impairment. Renal impairment colistin is less frequent than initially reported.
To assess the effect of combination antibiotic empirical therapy on 30-day case-fatality rate in neutropenic cancer patients with Pseudomonas aeruginosa (PA) bacteremic pneumonia. This was a multinational, retrospective cohort study onco-hematological PA bloodstream infection (BSI) (2006−2018). The appropriate therapy, monotherapy and inappropriate [IEAT] assessed only Among 1017 BSI episodes, pneumonia source 294 (28.9%). those, 52 (17.7%) were caused by multidrug-resistant (MDR) strain 68...
Saksenaea erythrospora is a species of the order Mucorales recently described and reported as cause human mucormycosis. We report case S. in man involved serious sailing accident causing deep skin soft tissue contamination with soil water. Direct microscopic examination clinical sample Giemsa stains showed hyaline non-septate hyphae belonging to . Fungal identification was performed by culture biopsy material on SDA, floating an agar block containing fungus nutritionally deficient medium...
We conducted a retrospective review of 130 occupational blood borne pathogens exposure (BBP-OE) records at Centro de Estudios Médicos e Investigaciones Clínicas, university hospital with an ongoing educational program and postexposure management for healthcare workers (HCWs) since 1995, in order to evaluate adherence BBP-OE program. compared HCWs from our institution (Group 1) independent institutions that contract 2). Compliance standard precautions Group 1 was inadequate 77%, 23%, 16%...
Introduction Bloodstream infection (BSI) due to extended-spectrum β-lactamase-producing Gram-negative bacilli (ESBL-GNB) is increasing at an alarming pace worldwide. Although β-lactam/β-lactamase inhibitor (BLBLI) combinations have been suggested as alternative carbapenems for the treatment of BSI these resistant organisms in general population, their usefulness ESBL-GNB haematological patients with neutropaenia yet be elucidated. The aim BICAR study compare efficacy BLBLI that this...
Ritonavir strongly inhibits cytochrome P450, thus altering the metabolism of other drugs. We report on an HIV-positive man who, his 13th day ritonavir therapy, developed severe ergotism after self-administration low doses ergotamine. Drug interactions, degree responsibility patient and availability over-the-counter medications must be considered when prescribing antiretroviral therapy.