A5082676803- Infective Endocarditis Diagnosis and Management
- Antifungal resistance and susceptibility
- Fungal Infections and Studies
- Antimicrobial Resistance in Staphylococcus
- SARS-CoV-2 and COVID-19 Research
- Bacterial Identification and Susceptibility Testing
- Streptococcal Infections and Treatments
- Antibiotics Pharmacokinetics and Efficacy
- SARS-CoV-2 detection and testing
- Infectious Aortic and Vascular Conditions
- Clostridium difficile and Clostridium perfringens research
- COVID-19 Clinical Research Studies
- Infectious Diseases and Mycology
- Cardiac Valve Diseases and Treatments
- Neutropenia and Cancer Infections
- Microscopic Colitis
- Pneumonia and Respiratory Infections
- Antibiotic Resistance in Bacteria
- Antibiotic Use and Resistance
- Nail Diseases and Treatments
- Tuberculosis Research and Epidemiology
- Nosocomial Infections in ICU
- Pneumocystis jirovecii pneumonia detection and treatment
- Plant Pathogens and Fungal Diseases
- Bacillus and Francisella bacterial research
Hospital General Universitario Gregorio Marañón
2015-2025
Hospital Universitario de Canarias
2025
Centro de Investigación Biomédica en Red
2024
Universidad Complutense de Madrid
2015-2023
Centro de Investigación Biomédica en Red de Enfermedades Respiratorias
2015-2021
Hospital Universitario Puerta de Hierro Majadahonda
2021
Instituto de Salud Carlos III
2021
Hospital Universitario De Cabueñes
2017-2018
Hospital Clínic de Barcelona
2012
Abstract Background There is a paucity of knowledge on the long-term outcome in patients diagnosed with COVID-19. We describe cohort constellation symptoms occurring four weeks after diagnosis causing different degrees reduced functional capacity. Although hypothesis have been proposed to explain this condition like persistent immune activation or immunological dysfunction, date, no physiopathological mechanism has identified. Consequently, there are therapeutic options besides symptomatic...
To test the hypothesis that addition of an aminoglycoside to a β-lactam antibiotic could provide better outcomes than monotherapy for initial empirical treatment hematological neutropenic patients with subsequently documented Gram-negative bacillus (GNB) bloodstream infection (BSI), multinational, retrospective, cohort study GNB BSI episodes in six centers (2010 2017) was conducted. Combination therapy (β-lactam plus aminoglycoside) compared monotherapy. The primary endpoint case fatality...
This study aimed to examine the relationship among adequate dose, serum concentration and clinical outcome in a non-selected group of hospitalized patients receiving antifungals.Prospective cross-sectional performed between March 2015 June 2015. Dosage antifungals was considered according IDSA guidelines, whereas trough concentrations (determined with HPLC) were as follows: fluconazole > 11 µg/ml, echinocandins 1 voriconazole 1-5.5 µg/ml posaconazole 0.7 µg/ml.During period, 84 (65.4% male,...
Abstract We assessed the performance of Abbott's SARS-CoV-2 IgG assay and Panbio TM COVID-19 IgG/IgM rapid test device for diagnosis either active or cured COVID-19. Three cohorts patients were chosen. Cohort 1, (n = 65) who attended emergency department on March 30, 2020 with clinical suspicion 56 proven/probable COVID-19). 2, hospital workers 92) had been 40) not 52) diagnosed asymptomatic at time sampling. 3, 38) cared before start pandemic. Detection serum antibodies was done using...
Studies investigating the impact of cardiogenic shock (CS) on endocarditis are lacking.Prospectively collected cohort from 35 Spanish centers (2008-2018). Logistic regression analyses were performed to identify risk factors for developing CS and predictors mortality.Among 4856 patients, 1652 (34%) had acute heart failure (AHF) 244 (5%) CS. Compared with patients without AHF but no CS, presented higher rates surgery (40.5%, 52.5%, 68%; P < .001) in-hospital mortality (16.3%, 39.1%, 52.5%)....
We sought to assess the characteristics and outcomes of neutropenic hematologic patients with Pseudomonas aeruginosa (PA) bloodstream infection (BSI) treated ceftolozane-tazobactam (C/T). conducted a multicenter, international, matched-cohort study PA BSI episodes in who received C/T. Controls were other antibiotics. Risk factors for overall 7-day 30-day case fatality rates analyzed. compared 44 cases 88 controls. Overall, 91% caused by multidrug-resistant (MDR) strains. An endogenous source...
Pneumocystis jirovecii pneumonia (PJP) in immunocompromised patients entails high mortality and requires adequate laboratory diagnosis. We compared the performance of a real time-PCR assay against immunofluorescence (IFA) routine large microbiology laboratory. Different respiratory samples from HIV non-HIV-infected were included. The retrospective analysis used data September 2015 to April 2018, which included all for P. test was requested. A total 299 tested (bronchoalveolar lavage fluid (n...
Background: Stroke is a common complication of infective endocarditis (IE). Our aim was to describe the prevalence and prognostic impact stroke in national cohort IE. Methods: Consecutive inclusion at 46 Spanish hospitals between 2008 2021. Results: Out 5667 IE cases, 1125 had acute (19.8%): 818 ischemic strokes (811 cardioembolic (193 with hemorrhagic transformation), 4 transient attacks, 3 lacunar infarctions), 127 intracranial hemorrhages, 27 other neurological complications (cerebral...
The use of venoarterial (VA) extracorporeal membrane oxygenation therapy (ECMO) in patients admitted to cardiac intensive care units (CICU) has increased. Data regarding infections this population are scarce. In retrospective study, we analyzed the risk factors, outcome, and predictors in-hospital mortality due nosocomial with ECMO a single coronary unit between July 2013 March 2019 treated VA-ECMO for >48 h. From 69 h, (median age 58 years), 29 (42.0%) developed 34 episodes an infection...
Background. The management and outcomes of nontuberculous mycobacterial (NTM) infections in solid organ transplant (SOT) recipients are poorly characterized. We aimed to describe the 1-y mortality these patients. Methods. Retrospective, multinational, 1:2 matched case-control study included SOT aged 12 y old or older diagnosed with NTM infection between January 1, 2008, December 31, 2018. Controls were on transplanted organs, treatment center, posttransplant survival at least equal time...
This study examines the impacts of a skin and soft tissue infection (SSTI) management program involving rapid diagnostic algorithm (Gram stain plus real-time PCR, GeneXpert® MRSA/SA SSTI) performed directly on clinical samples antimicrobial stewardship (AMS) counseling responsible physician.Participants were 155 consecutive adult inpatients with SSTI good quality submitted to microbiology laboratory from April 2016 January 2017. Results test AMS recommendations phoned through physician. The...
We aimed to describe the frequency of use and effectiveness bezlotoxumab (BZX) fecal microbiota transplantation (FMT) in patients with Clostridioides difficile infection (CDI) real-world practice.This was a retrospective study conducted university hospital which adult treated BZX or FMT from January 2018 April 2021 were included. The primary objective evaluate preventing early (within 8 weeks) late 1 year) CDI recurrences (rCDI). A multivariate analysis risk factors for recurrence...
The significance of Clostridium difficile (CD) in the stools children 2 years old or younger remains unclear. aim this study was to investigate risk factors and clinical evolution diarrheic ≤2 with without CD their stools.From January 1, 2012 December 31, 2013, all stool samples received our laboratory were screened for CD. We randomly selected (n = 100) an isolation toxigenic compared them CD.Cases controls appropriately matched age sex. found no significant differences between Of cases, we...
The emergence of the Omicron variant SARS-CoV-2 represented a challenge to treatment COVID-19 using monoclonal antibodies. Only Sotrovimab maintained partial activity, allowing it be used in high-risk patients infected with variant. However, reports resistance mutations demand efforts better understand intra-patient resistance. A retrospective genomic analysis was conducted on respiratory samples from immunocompromised who received at our hospital between December 2021 and August 2022. study...
Little is known about the characteristics and impact of septic shock (SS) on outcomes infective endocarditis (IE). We aimed to investigate patients with IE presenting SS compare them those sepsis (Se) neither Se nor (no-Se-SS).This a prospective cohort study 4864 from 35 Spanish centers (2008 2018). Logistic regression analyses were performed identify risk factors for mortality.Septic presented in 597 (12.3%) 559 (11.5%) patients, respectively. Patients younger significantly higher rates...
Summary Background Non‐ Aspergillus mould infections such as those caused by Scedosporium apiospermum or Lomentospora prolificans are an emerging threat. Few studies have monitored their long‐term incidence. Objectives To analyse the epidemiology, risk factors, clinical features and incidence of patients with proven probable infections. Patients/Methods Patients admitted to Gregorio Marañón Hospital between 1998 2017 from whom Scedosporium/Lomentospora was isolated were studied. Subjects...
Abstract Background SARS-CoV-2 recombinants involving the divergent Delta and Omicron lineages have been described, one of them, “Kraken” (XBB.1.5), has recently a matter concern. Recombination requires coexistence two strains in same individual. Only limited number studies focused on identification co-infections are restricted to Delta/Omicron lineages. Methods We performed systematic throughout pandemic (7609 different patients sequenced), not biassed towards involvement highly Through...
Summary Background Cryptococcus isolates with high MIC s to fluconazole are increasingly reported, and a potential clinical impact has been advocated. However, there different methods evaluate comparative analysis among such techniques their comprehensive correlation outcome not available. Methods Over 13‐year period (2000‐2013), were determined for 62 cryptococcal recovered from 22 patients cryptococcosis using CLSI M27‐A3, EUCAST , E test Sensititre YeastOne, simultaneously. The...