Arístides de Alarcón
A5070851237- Infective Endocarditis Diagnosis and Management
- Antimicrobial Resistance in Staphylococcus
- Streptococcal Infections and Treatments
- Cardiac Valve Diseases and Treatments
- Antibiotics Pharmacokinetics and Efficacy
- Orthopedic Infections and Treatments
- Infectious Aortic and Vascular Conditions
- Bacterial Identification and Susceptibility Testing
- HIV/AIDS drug development and treatment
- HIV Research and Treatment
- Cardiac Structural Anomalies and Repair
- Transplantation: Methods and Outcomes
- Otolaryngology and Infectious Diseases
- Cardiac pacing and defibrillation studies
- Antifungal resistance and susceptibility
- Vector-borne infectious diseases
- Analytical Methods in Pharmaceuticals
- HIV-related health complications and treatments
- Whipple's Disease and Interleukins
- HIV/AIDS Research and Interventions
- Mechanical Circulatory Support Devices
- Viral Infections and Immunology Research
- Atrial Fibrillation Management and Outcomes
- Central Venous Catheters and Hemodialysis
- Antibiotic Resistance in Bacteria
Hospital Universitario Virgen del Rocío
2016-2025
Instituto de Salud Carlos III
2017-2025
Instituto de Biomedicina de Sevilla
2017-2025
Universidad de Sevilla
2017-2025
Centro de Investigación Biomédica en Red
2023-2024
Consejo Superior de Investigaciones Científicas
2022-2023
Centre for Biomedical Network Research on Rare Diseases
2023
Centro de Investigación en Red en Enfermedades Cardiovasculares
2022
Donostia Unibertsitate Ospitalea
2021
Gamesa (Spain)
2020
Background. The aim of this study was to compare the effectiveness ampicillin plus ceftriaxone (AC) and gentamicin (AG) combinations for treating Enterococcus faecalis infective endocarditis (EFIE). Methods. An observational, nonrandomized, comparative multicenter cohort conducted at 17 Spanish 1 Italian hospitals. Consecutive adult patients diagnosed EFIE were included. Outcome measurements death during treatment 3 months follow-up, adverse events requiring withdrawal, failure a change...
Infective endocarditis (IE) has high mortality and morbidity requires long hospital stays to deliver the antibiotic treatment recommended in clinical practice guidelines. The objectives were analyze health outcomes of use dalbavancin (DBV) consolidation IEs caused by Gram-positive cocci (GPC) perform a pharmacoeconomic study. This observational, retrospective, Spanish multicenter study patients with IE who received DBV as part phase followed for at least 12 months. was approved Provincial...
Several aspects of the occurrence and management mycotic aneurysm (MA) in patients with infective endocarditis (IE) have not been studied. To determine incidence factors associated MA presence rupture to assess evolution those initially unruptured MA. Prospective multicenter cohort including all definite IE between January 2008 December 2020. Of 4548 cases, 85 (1.9%) developed Forty-six (54.1%) had intracranial 39 (45.9%) extracranial Rupture occurred (45.9%). Patients ruptured higher 1-year...
Despite medical advances, mortality in infective endocarditis (IE) is still very high. Previous studies on prognosis IE have observed conflicting results. The aim of this study was to identify predictors in-hospital a large multicenter cohort left-sided IE. An observational conducted from January 1984 December 2006 seven hospitals Andalusia, Spain. Seven hundred and five left-side patients were included. main outcome measure mortality. Several prognostic factors analysed by univariate tests...
The POET trial demonstrated that moving from intravenous to oral antibiotics in stable patients with left-sided infective endocarditis (IE) was noninferior fully parenteral treatment. However, it did not compare outpatient strategies. OraPAT-IE GAMES is a noninferiority, multicenter, randomized, open-label study aimed partial versus antibiotic therapy (OPAT) for consolidation of treatment IE. A total 342 IE caused by selected micro-organisms will eventually be included. After minimum 10 days...
Fever of intermediate duration (FID), characterized by a febrile syndrome lasting from 7 to 28 days, is frequent condition in clinical practice, but its epidemiological and etiologic features are not well described. Murine typhus (MT) worldwide illness; nevertheless, our knowledge, no studies describing characteristics have been performed the south Spain. Also, significance as cause FID unknown.To determine features, characteristics, prognosis MT and, prospectively, incidence FID.Prospective...
Studies investigating the impact of cardiogenic shock (CS) on endocarditis are lacking.Prospectively collected cohort from 35 Spanish centers (2008-2018). Logistic regression analyses were performed to identify risk factors for developing CS and predictors mortality.Among 4856 patients, 1652 (34%) had acute heart failure (AHF) 244 (5%) CS. Compared with patients without AHF but no CS, presented higher rates surgery (40.5%, 52.5%, 68%; P < .001) in-hospital mortality (16.3%, 39.1%, 52.5%)....
Prosthetic valve endocarditis (PVE) is a serious infection associated with high mortality that often requires surgical treatment.Study on clinical characteristics and prognosis of large contemporary prospective cohort prosthetic included patients diagnosed between January 2008 December 2020. Univariate multivariate analysis factors in-hospital was performed.The study 1354 cases PVE. The median age 71 years an interquartile range 62-77 66.9% the were male. Patients during first year after...
We aimed to identify clinical factors associated with recurrent infective endocarditis (IE) episodes. The characteristics of 2816 consecutive patients definite IE (January 2008–2018) were compared according the development a second episode IE. A total 2152 out 2282 (94.3%) patients, who discharged alive and followed-up for at least first year, presented single IE, whereas 130 (5.7%) recurrence; 70 cases (53.8%) due other microorganisms (reinfection), 60 (46.2%) same microorganism causing...
Introduction Sex-dependent differences of infective endocarditis (IE) have been reported. Women suffer from IE less frequently than men and tend to present more severe manifestations. Our objective was analyse the sex-based in clinical presentation, treatment, prognosis. Material methods We analysed sex modality treatment prognosis a national-level multicentric cohort between 2008 2018. All data were prospectively recorded by GAMES (Spanish Collaboration on Endocarditis). Results A total...
Background. Infective endocarditis (IE) is a severe condition. Our aim was to describe the profile and prognosis of patients with multivalvular infective (MIE) compare them single-valve IE (SIE). Methods. We used retrospective analysis Spanish Registry (2008−2020). Results. From 4064 definite cases valvular IE, 577 (14.2%) had MIE. In MIE, most common locations were mitral (552, 95.7%) aortic (550, 95.3%), mitral-aortic involvement present in 507 (87.9%). The etiologies S. viridans (192,...
Background. Infective Endocarditis (IE) is a severe condition. Diabetes mellitus (DM) has been associated with poor prognosis in other settings. Our aim was to describe the profile and of IE without DM analyze prognostic relevance DM-related organ damage. Methods. Retrospective analysis Spanish Registry (2008−2020). Results. The cohort comprises 5590 patients mean age 65.0 ± 15.5 years; 3764 (67.3%) were male. found 1625 (29.1%) 515 presented prevalence during first half study period 27.6%...
ABSTRACT Infective endocarditis (IE) caused by Enterococcus spp. represents the third most common cause of IE, with high rates relapse compared other bacteria. Interestingly, late relapses (>6 months) have only been described in faecalis, but here we describe first reported IE faecium more than a year (17 after initial episode. Firstly, multi locus sequence typing (MLST), demonstrated that both isolates (EF646 and EF641) belong to same type (ST117). Considering EF641 was able overcome...